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Chemical Compound Review:

AG-K-20385 1-[5-[[[[5-(6-aminopurin-9- yl)-3,4...

Synonyms: KST-1B7104, CTK5C1340, AR-1B9391, AC1L19NP, AC1Q5U1R, ...

Jacobson, M.K. et al., Zhou, T. et al., Rizzi, M. et al., Zhang, H. et al.

Zhang, Zhou, Kurnasov, Cheek, Grishin, Osterman,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of deamido-NAD

Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD [1].

High impact information on deamido-NAD

The deamido-NAD+ binding site, located at the subunit interface, is occupied by one ATP molecule, pointing towards the catalytic center [2].
We have solved the crystal structures of human NMNAT in complex with NAD, deamido-NAD, and a non-hydrolyzable TAD analogue beta-CH(2)-TAD [3].
Preparation of cyclic ADP-ribose, 2'-phospho-cyclic ADP-ribose, and nicotinate adenine dinucleotide phosphate: possible second messengers of calcium signaling [4].

References

Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD. Zhang, H., Zhou, T., Kurnasov, O., Cheek, S., Grishin, N.V., Osterman, A. Structure (Camb.) (2002) [Pubmed]
Crystal structure of NH3-dependent NAD+ synthetase from Bacillus subtilis. Rizzi, M., Nessi, C., Mattevi, A., Coda, A., Bolognesi, M., Galizzi, A. EMBO J. (1996) [Pubmed]
Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin. Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H. J. Biol. Chem. (2002) [Pubmed]
Preparation of cyclic ADP-ribose, 2'-phospho-cyclic ADP-ribose, and nicotinate adenine dinucleotide phosphate: possible second messengers of calcium signaling. Jacobson, M.K., Coyle, D.L., Vu, C.Q., Kim, H., Jacobson, E.L. Meth. Enzymol. (1997) [Pubmed]

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