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Gene Review

NMNAT1  -  nicotinamide nucleotide adenylyltransferase 1

Homo sapiens

Synonyms: LCA9, NMN adenylyltransferase 1, NMNAT, NaMN adenylyltransferase 1, Nicotinamide mononucleotide adenylyltransferase 1, ...
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Disease relevance of NMNAT1


High impact information on NMNAT1

  • Analyses of the subcellular localization confirmed NMNAT1 to be a nuclear protein, whereas NMNAT2 and -3 were localized to the Golgi complex and the mitochondria, respectively [5].
  • Moreover, as opposed to preferred NAD+ synthesis by NMNAT1, the other two isoforms could also form NADH directly from the reduced nicotinamide mononucleotide, supporting a hitherto unknown pathway of NAD generation [5].
  • Pyridine nucleotide adenylyltransferase (PNAT) is an indispensable central enzyme in the NAD biosynthesis pathways catalyzing the condensation of pyridine mononucleotide (NMN or NaMN) with the AMP moiety of ATP to form NAD (or NaAD) [6].
  • The tiazofurin resistance is mainly associated with the low NMNAT activity in the cell [7].
  • Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT) is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+) [7].

Biological context of NMNAT1


Anatomical context of NMNAT1


Associations of NMNAT1 with chemical compounds


Other interactions of NMNAT1


Analytical, diagnostic and therapeutic context of NMNAT1


  1. Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. Sasaki, Y., Araki, T., Milbrandt, J. J. Neurosci. (2006) [Pubmed]
  2. Ribosylnicotinamide kinase domain of NadR protein: identification and implications in NAD biosynthesis. Kurnasov, O.V., Polanuyer, B.M., Ananta, S., Sloutsky, R., Tam, A., Gerdes, S.Y., Osterman, A.L. J. Bacteriol. (2002) [Pubmed]
  3. Protection of vincristine-induced neuropathy by Wld(S) expression and the independence of the activity of Nmnat1. Watanabe, M., Tsukiyama, T., Hatakeyama, S. Neurosci. Lett. (2007) [Pubmed]
  4. Three-minute high-performance liquid chromatographic assay for NMN adenylyltransferase using a 20-mm-long reversed-phase column. Emanuelli, M., Raffaelli, N., Amici, A., Fanelli, M., Ruggieri, S., Magni, G. J. Chromatogr. B, Biomed. Appl. (1996) [Pubmed]
  5. Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. Berger, F., Lau, C., Dahlmann, M., Ziegler, M. J. Biol. Chem. (2005) [Pubmed]
  6. Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis. Zhang, X., Kurnasov, O.V., Karthikeyan, S., Grishin, N.V., Osterman, A.L., Zhang, H. J. Biol. Chem. (2003) [Pubmed]
  7. Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin. Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H. J. Biol. Chem. (2002) [Pubmed]
  8. Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis. Garavaglia, S., D'Angelo, I., Emanuelli, M., Carnevali, F., Pierella, F., Magni, G., Rizzi, M. J. Biol. Chem. (2002) [Pubmed]
  9. Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis. Schweiger, M., Hennig, K., Lerner, F., Niere, M., Hirsch-Kauffmann, M., Specht, T., Weise, C., Oei, S.L., Ziegler, M. FEBS Lett. (2001) [Pubmed]
  10. Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas. Yalowitz, J.A., Xiao, S., Biju, M.P., Antony, A.C., Cummings, O.W., Deeg, M.A., Jayaram, H.N. Biochem. J. (2004) [Pubmed]
  11. Nicotinamide mononucleotide adenylyltransferase activity in human erythrocytes. Sestini, S., Ricci, C., Micheli, V., Pompucci, G. Arch. Biochem. Biophys. (1993) [Pubmed]
  12. Nuclear matrix-associated NMN adenylyltransferase activity in human placenta. Balducci, E., Emanuelli, M., Magni, G., Raffaelli, N., Ruggieri, S., Vita, A., Natalini, P. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  13. Enzyme activities leading to NAD synthesis in human lymphocytes. Sestini, S., Jacomelli, G., Pescaglini, M., Micheli, V., Pompucci, G. Arch. Biochem. Biophys. (2000) [Pubmed]
  14. Identification of a novel human nicotinamide mononucleotide adenylyltransferase. Raffaelli, N., Sorci, L., Amici, A., Emanuelli, M., Mazzola, F., Magni, G. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  15. Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN. Werner, E., Ziegler, M., Lerner, F., Schweiger, M., Heinemann, U. FEBS Lett. (2002) [Pubmed]
  16. Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors. Franchetti, P., Petrelli, R., Cappellacci, L., Pasqualini, M., Vita, P., Sorci, L., Mazzola, F., Raffaelli, N., Magni, G. Nucleosides Nucleotides Nucleic Acids (2005) [Pubmed]
  17. Modulation of cytotoxicity of benzamide riboside by expression of NMN adenylyltransferase. Yalowitz, J.A., Jayaram, H.N. Current medicinal chemistry. (2002) [Pubmed]
  18. Chronic hypoxia in Andeans; are there lessons for neurology at sea level? Appenzeller, O., Minko, T., Qualls, C., Pozharov, V., Gamboa, J., Gamboa, A., Pakunlu, R.I. J. Neurol. Sci. (2006) [Pubmed]
  19. Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis. Jayaram, H.N., Cooney, D.A., Grusch, M., Krupitza, G. Current medicinal chemistry. (1999) [Pubmed]
  20. Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase. Emanuelli, M., Carnevali, F., Saccucci, F., Pierella, F., Amici, A., Raffaelli, N., Magni, G. J. Biol. Chem. (2001) [Pubmed]
  21. Crystallization and preliminary X-ray analysis of human nicotinamide mononucleotide adenylyltransferase (NMNAT). Werner, E., Ziegler, M., Lerner, F., Schweiger, M., Muller, Y.A., Heinemann, U. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
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