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Chemical Compound Review:

Norelgestromin (8R,9S,10R,13S,14S,17S)-13- ethyl-17...

Synonyms: AG-F-81357, LS-62094, CTK8F3207, LS-187018, LS-187646, ...

LaGuardia, K.D. et al., Kuhnz, W. et al., Abrams, L.S. et al., Prifti, S. et al., Abrams, L.S. et al.

LaGuardia, Fisher, Bainbridge, LoCoco, Friedman, Abrams, Skee, Natarajan, Wong,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RWJ 10553

Induction of androgen receptor activity by norgestimate and norelgestromin in MDA-MB 231 breast cancer cells [1].

High impact information on RWJ 10553

Coadministration of the patch with tetracycline did not affect the pharmacokinetics of norelgestromin and EE [2].
Comparative progestational activity of norgestimate, levonorgestrel-oxime and levonorgestrel in the rat and binding of these compounds to the progesterone receptor [3].
A randomized clinical trial was conducted with 239 women at nine clinical research sites to compare bleeding profile, headache frequency, and subject satisfaction with the transdermal contraceptive, ORTHO EVRA (norelgestromin/ethinyl estradiol transdermal system) used in an extended regimen (84 days) with a traditional, 28-day cyclic regimen [4].

Biological context of RWJ 10553

Pharmacokinetics of norelgestromin and ethinyl estradiol from two consecutive contraceptive patches [5].

References

Induction of androgen receptor activity by norgestimate and norelgestromin in MDA-MB 231 breast cancer cells. Prifti, S., Lelle, I., Strowitzki, T., Rabe, T. Gynecol. Endocrinol. (2004) [Pubmed]
Pharmacokinetic overview of Ortho Evra/Evra. Abrams, L.S., Skee, D., Natarajan, J., Wong, F.A. Fertil. Steril. (2002) [Pubmed]
Comparative progestational activity of norgestimate, levonorgestrel-oxime and levonorgestrel in the rat and binding of these compounds to the progesterone receptor. Kuhnz, W., Fritzemeier, K.H., Hegele-Hartung, C., Krattenmacher, R. Contraception. (1995) [Pubmed]
Suppression of estrogen-withdrawal headache with extended transdermal contraception. LaGuardia, K.D., Fisher, A.C., Bainbridge, J.D., LoCoco, J.M., Friedman, A.J. Fertil. Steril. (2005) [Pubmed]
Pharmacokinetics of norelgestromin and ethinyl estradiol from two consecutive contraceptive patches. Abrams, L.S., Skee, D.M., Wong, F.A., Anderson, N.J., Leese, P.T. Journal of clinical pharmacology. (2001) [Pubmed]

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