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Chemical Compound Review:

AC1O3SV9 aluminum hydroxide phosphate

Synonyms: Aluminum hydroxide phosphate

Wu, Y. et al., Palker, T.J. et al.

Palker, Monteiro, Martin, Kakareka, Smith, Cook, Joyce, Jansen, Wu, Przysiecki, Flanagan, Bello-Irizarry, Ionescu, Muratova, Dobrescu, Lambert, Keister, Rippeon, Long, Shi, Caulfield, Shaw, Saul, Shiver, Miller,

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Disease relevance of aluminum hydroxide phosphate

Here, we show the induction of persistent, high-titer antibody responses to recombinant Pfs25H, a human malarial transmission-blocking protein vaccine candidate, after chemical conjugation to the outer-membrane protein complex (OMPC) of Neisseria meningitidis serogroup B and adsorption to aluminum hydroxyphosphate [1].
We evaluated antibody, cytokine (IFN-gamma, IL-5, TNF-alpha), and cytotoxic T lymphocyte (CTL) responses in chimpanzees immunized with monovalent or quadrivalent (HPV-6, -11, -16, -18) L1 virus-like particle (VLP) vaccines administered i.m. on aluminum hydroxyphosphate (alum) at weeks 0, 8 and 24 [2].

References

Sustained high-titer antibody responses induced by conjugating a malarial vaccine candidate to outer-membrane protein complex. Wu, Y., Przysiecki, C., Flanagan, E., Bello-Irizarry, S.N., Ionescu, R., Muratova, O., Dobrescu, G., Lambert, L., Keister, D., Rippeon, Y., Long, C.A., Shi, L., Caulfield, M., Shaw, A., Saul, A., Shiver, J., Miller, L.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Antibody, cytokine and cytotoxic T lymphocyte responses in chimpanzees immunized with human papillomavirus virus-like particles. Palker, T.J., Monteiro, J.M., Martin, M.M., Kakareka, C., Smith, J.F., Cook, J.C., Joyce, J.G., Jansen, K.U. Vaccine (2001) [Pubmed]

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