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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

KBioGR_002482     3-hydroxyiminobutan-2-one

Synonyms: KBioSS_002489, AC1O4QTS, KBio2_002482, KBio2_005050, KBio2_007618, ...
 
 
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High impact information on C07509

  • The coupled urease/glutamate dehydrogenase method (used in the DuPont aca) showed positive interference from ammonia, as expected; with the diacetylmonoxime (Technicon (12/60) and the urease conductivity (Beckman ASTRA) methods we saw no such interference [1].
  • Incubation in calcium-free medium or medium containing 2,3 butanedione-monoxime (BDM), which decreases myofibrillar calcium sensitivity, delayed but did not prevent the cell shape changes and loss of membrane integrity [2].
  • The new method appears to be more accurate at low levels of ornithine carbamoyltransferase activity than the diacetylmonoxime method [3].
  • The present study aimed to investigate whether a different origin of the myocardial sample or pretreatment with the cardioprotective agent 2,3-butanedione-monoxime (BDM) influences the force-frequency-relationship in electrically driven muscle strips taken from failing and nonfailing human myocardium [4].
  • METHODS AND RESULTS: We recorded transmembrane potential from the surface of isolated rabbit hearts (N = 7) in the presence of 15 mmol/L of diacetylmonoxime using a video imaging system [5].
 

Biological context of C07509

 

Anatomical context of C07509

References

  1. Urinary urea: are currently available methods adequate for revival of an almost abandoned test? Eckfeldt, J., Levine, A.S., Greiner, C., Kershaw, M. Clin. Chem. (1982) [Pubmed]
  2. The role of calcium in the toxic effects of tert-butyl hydroperoxide on adult rat cardiac myocytes. Daly, M.J., Young, R.J., Britnell, S.L., Nayler, W.G. J. Mol. Cell. Cardiol. (1991) [Pubmed]
  3. A novel method for measuring serum ornithine carbamoyltransferase. Ishikawa, H., Matsuzawa, T., Ohashi, K., Nagamura, Y. Ann. Clin. Biochem. (2003) [Pubmed]
  4. Force-frequency-relation in human atrial and ventricular myocardium. Schwinger, R.H., Böhm, M., Koch, A., Uhlmann, R., Uberfuhr, P., Kreuzer, E., Reichart, B., Erdmann, E. Mol. Cell. Biochem. (1993) [Pubmed]
  5. Interdependence of virtual electrode polarization and conduction velocity during premature stimulation. Gray, R.A., Iyer, A., Berenfeld, O., Pertsov, A.M., Hyatt, C.J. Journal of electrocardiology. (2006) [Pubmed]
  6. Inhibition by 2,3-butanedione-monoxime of mitochondrial ADP-dependent respiration and muscle contraction. Mojon, D., Zhang, W., Oetliker, H. Biochem. Mol. Biol. Int. (1993) [Pubmed]
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