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Chemical Compound Review

CARDAMOMIN     (E)-1-(2,4-dihydroxy-6- methoxy-phenyl)-3...

Synonyms: Cardamonin, CHEMBL378104, SureCN449220, CHEBI:449910, MEGxp0_000534, ...
 
 
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Disease relevance of AIDS345183

  • Alpinetin and cardamonin, two of the main constituents from the seeds of Alpinia katsumadai Hayata, have been used in traditional herbs as antibacterial, anti-inflammatory, and other important therapeutic activities of significant potency and low systemic toxicity [1].
 

High impact information on AIDS345183

  • In this report, the effects of cardamonin (2',4'-dihydroxy-6'-methoxychalcone), a chalcone that we have previously isolated from Alpinia rafflesiana, was evaluated upon two cellular systems that are repeatedly used in the analysis of anti-inflammatory bioactive compounds namely RAW 264.7 cells and whole blood [2].
  • Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells [3].
  • Specific interaction of chalcone-protein: cardamonin binding site II on the human serum albumin molecule [4].
  • The vascular effects of cardamonin and alpinetin from Alpinia henryi K [5].
 

Analytical, diagnostic and therapeutic context of AIDS345183

  • The alterations of protein secondary structure in the presence of cardamonin in aqueous solution were quantitatively calculated by the evidence from CD and FTIR spectroscopes with reductions of alpha-helices of about 20%, decreases of beta-sheet structures of about 14%, and increases of beta-turn structures of about 15% [4].

References

  1. Comparison of the characterization on binding of alpinetin and cardamonin to lysozyme by spectroscopic methods. He, W., Li, Y., Tang, J., Luan, F., Jin, J., Hu, Z. Int. J. Biol. Macromol. (2006) [Pubmed]
  2. Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. Ahmad, S., Israf, D.A., Lajis, N.H., Shaari, K., Mohamed, H., Wahab, A.A., Ariffin, K.T., Hoo, W.Y., Aziz, N.A., Kadir, A.A., Sulaiman, M.R., Somchit, M.N. Eur. J. Pharmacol. (2006) [Pubmed]
  3. Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells. Israf, D.A., Khaizurin, T.A., Syahida, A., Lajis, N.H., Khozirah, S. Mol. Immunol. (2007) [Pubmed]
  4. Specific interaction of chalcone-protein: cardamonin binding site II on the human serum albumin molecule. He, W., Li, Y., Liu, J., Hu, Z., Chen, X. Biopolymers (2005) [Pubmed]
  5. Vasorelaxant effects of cardamonin and alpinetin from Alpinia henryi K. Schum. Wang, Z.T., Lau, C.W., Chan, F.L., Yao, X., Chen, Z.Y., He, Z.D., Huang, Y. J. Cardiovasc. Pharmacol. (2001) [Pubmed]
 
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