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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Spectroscopy, Fourier Transform Infrared

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Disease relevance of Spectroscopy, Fourier Transform Infrared

  • Structure and oxidation state of the Ni-Fe cofactor of the NAD-reducing soluble hydrogenase (SH) from Ralstonia eutropha were studied employing X-ray absorption spectroscopy (XAS) at the Ni K-edge, EPR, and FTIR spectroscopy [1].
  • Proton uptake by carboxylic acid groups upon photoreduction of the secondary quinone (QB) in bacterial reaction centers from Rhodobacter sphaeroides: FTIR studies on the effects of replacing Glu H173 [2].
  • The amplitude of this signal is reduced by approximately half in FTIR spectra of Synechocystis mutants in which His PsaB 651, the axial ligand to one of the two Chl molecules in P700, is replaced by Cys, Gln, or Leu [3].
  • In this study, we examine the interaction between two bacterial proteins, namely HPr and IIAmtl of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system, using FTIR spectroscopy [4].
  • Electrochemical and FTIR spectroscopic characterization of the cytochrome bc1 complex from Paracoccus denitrificans: evidence for protonation reactions coupled to quinone binding [5].

High impact information on Spectroscopy, Fourier Transform Infrared

  • Anesthetic potencies of these alkanols, estimated by the activity of brine shrimps, were linearly related to hydrogen bond-breaking activities below C10 and agreed with the FTIR data in the cutoff at C10 [6].
  • The secondary structure was investigated by Fourier transform infrared (FTIR) spectroscopy after the extramembrane moieties of the protein from the extracellular and intracellular sides of the membrane were removed by proteolysis using proteinase K [7].
  • The molecular reaction mechanism of the GTPase-activating protein (GAP)-catalyzed GTP hydrolysis by Ras was investigated by time resolved Fourier transform infrared (FTIR) difference spectroscopy using caged GTP (P(3)-1-(2-nitro)phenylethyl guanosine 5'-O-triphosphate) as photolabile trigger [8].
  • Results of FTIR indicated that the conformation of [Lys]10kDa-SP-B was comprised primarily of alpha-helical structure compared with a predominantly aggregated structure of unmodified poly(lysine) [9].
  • FTIR difference spectral changes in the bR570-to-K transition clearly indicate that bR570 contains a protonated Schiff base [10].

Chemical compound and disease context of Spectroscopy, Fourier Transform Infrared


Biological context of Spectroscopy, Fourier Transform Infrared

  • DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis [16].
  • Fibrils formed at pH 2.5 differ in fibrillation kinetics, morphology, thioflavin T staining and FTIR/CD spectra depending on salts, glucagon concentration and fibrillation temperature [17].
  • Modification of the phylloquinone in the A1 binding site in photosystem I studied using time-resolved FTIR difference spectroscopy and density functional theory [18].
  • A single-stranded, nonrepetitive 7-mer oligoribonucleotide (7-mer RNA) and four different variants having the same base sequence but with a single deoxyribose sugar at different positions in the strands have been studied by ultraviolet (UV) absorption, circular dichroism (CD), and Fourier transform infrared (FTIR) spectroscopy [19].
  • Using Fourier transform infrared (FTIR) difference spectroscopy, we have studied the impact of sites and extent of methylation of the retinal polyene with respect to position and thermodynamic parameters of the conformational equilibrium between the Meta I and Meta II photoproducts of rhodopsin [20].

Anatomical context of Spectroscopy, Fourier Transform Infrared

  • Fourier transform infrared (FTIR) spectroscopy has been used for the detailed characterization and quantification of the secondary structure of bovine rhodopsin in native disc membranes [21].
  • Alizarin red staining, microcomputerized tomography (micro CT), and FTIR imaging spectroscopy (FT-IRIS) confirmed a significant overall decrease of mineral density in the cartilage and bone matrix of TNAP-deficient mice [22].
  • Interactions of phosphate groups of ATP and Aspartyl phosphate with the sarcoplasmic reticulum Ca2+-ATPase: an FTIR study [23].
  • Endosperm cell walls of cultivars of wheat (Triticum aestivum L.) selected for their endosperm texture (two soft and two hard) were analysed in situ by Fourier transform infrared (FTIR) microspectroscopy [24].
  • This suggests that common methods of sterilization alter the structure of the dentin, but gamma irradiation shows promise as a method which both is effective and introduces no detectable changes as measured by FTIR, UV/VIS/NIR, or permeability [25].

Associations of Spectroscopy, Fourier Transform Infrared with chemical compounds

  • X-ray diffraction analysis along with resolution enhanced FTIR spectroscopy demonstrated the mineral phase to be a poorly crystalline hydroxyapatite [26].
  • The Fourier transform infrared (FTIR) amide I band shows that antiparallel beta-sheet structure increases with syneresis in the tau 2-19 hydrogel [27].
  • The comparison of FTIR results for PHFs with collagen I gel and polyproline demonstrates that the secondary structure of PHFs is polyproline II [27].
  • For molecules with a unique spectral signature, such as CS, the FTIR technique coupled with multivariate analysis can define a unique spatial distribution [28].
  • Several bands for carboxylate symmetric stretching modes in an S(2)/S(1) FTIR difference spectrum were affected by selective (13)C labeling of the alpha-carboxylate of Ala with l-[1-(13)C]alanine, whereas most of the isotopic effects failed to be induced in a site-directed mutant in which Ala-344 was replaced with Gly [29].

Gene context of Spectroscopy, Fourier Transform Infrared

  • The role of DMP1 in mineralization was analyzed by comparing bone mineral and matrix properties in dmp1-null female mice to heterozygous and wildtype controls by FTIR imaging spectroscopy [16].
  • The CD and FTIR spectra of SP-B isolated from all extracts were consistent with a secondary structure dominated by alpha-helix [30].
  • The CD and FTIR spectra of the first SP-C corresponded to an alpha-helical secondary structure and the spectra of the second SP-C corresponded to a mixture of alpha-helical and beta-sheet conformation [30].
  • Using Fourier transform infrared (FTIR), we tested whether this interaction can induce structure in the AR AF1 [31].
  • Alizarin Red S staining of cells and calcium assay indicated that BMP-7, DEX, and FGF-2 enhanced calcium mineral deposition, but FTIR spectroscopic analysis demonstrated no formation of HA similar to human bone in control, PDGF-BB-, and FGF-2-treated samples [32].

Analytical, diagnostic and therapeutic context of Spectroscopy, Fourier Transform Infrared

  • Interference microscopy and FTIR microscopy are applied to study intracrystalline concentration profiles of methanol in CrAPO-5 zeolite crystals [33].
  • Resonance Raman and FTIR spectroscopies show that the two classes of guanidine derivatives induce different polar effects on Fe(II)CO environment [34].
  • The isomeric structures of the Dy3N@C80 cluster fullerene were analyzed by studying HPLC retention behavior, laser desorption time-of-flight (LD-TOF) mass spectrometry, and UV-Vis-NIR and FTIR spectroscopy [35].
  • A generic method is described for the reversible immobilization of polyhistidine-bearing polypeptides and proteins on attenuated total reflecting (ATR) sensor surfaces for the detection of biomolecular interactions by FTIR spectroscopy [36].
  • The structural evolution through the amorphization process was accompanied by various characterization techniques, such as X-ray diffraction, Fourier-transformed IR spectroscopy (FTIR), high-resolution transmission electron microscopy (HR-TEM), and Raman spectroscopy [37].


  1. Structural and oxidation-state changes at its nonstandard Ni-Fe site during activation of the NAD-reducing hydrogenase from Ralstonia eutropha detected by X-ray absorption, EPR, and FTIR spectroscopy. Burgdorf, T., Löscher, S., Liebisch, P., Van der Linden, E., Galander, M., Lendzian, F., Meyer-Klaucke, W., Albracht, S.P., Friedrich, B., Dau, H., Haumann, M. J. Am. Chem. Soc. (2005) [Pubmed]
  2. Proton uptake by carboxylic acid groups upon photoreduction of the secondary quinone (QB) in bacterial reaction centers from Rhodobacter sphaeroides: FTIR studies on the effects of replacing Glu H173. Nabedryk, E., Breton, J., Okamura, M.Y., Paddock, M.L. Biochemistry (1998) [Pubmed]
  3. The two histidine axial ligands of the primary electron donor chlorophylls (P700) in photosystem I are similarly perturbed upon P700+ formation. Breton, J., Xu, W., Diner, B.A., Chitnis, P.R. Biochemistry (2002) [Pubmed]
  4. Potential of 13C and 15N labeling for studying protein-protein interactions using Fourier transform infrared spectroscopy. Haris, P.I., Robillard, G.T., van Dijk, A.A., Chapman, D. Biochemistry (1992) [Pubmed]
  5. Electrochemical and FTIR spectroscopic characterization of the cytochrome bc1 complex from Paracoccus denitrificans: evidence for protonation reactions coupled to quinone binding. Ritter, M., Anderka, O., Ludwig, B., Mäntele, W., Hellwig, P. Biochemistry (2003) [Pubmed]
  6. Anesthesia cutoff phenomenon: interfacial hydrogen bonding. Chiou, J.S., Ma, S.M., Kamaya, H., Ueda, I. Science (1990) [Pubmed]
  7. The transmembrane domains of the nicotinic acetylcholine receptor contain alpha-helical and beta structures. Görne-Tschelnokow, U., Strecker, A., Kaduk, C., Naumann, D., Hucho, F. EMBO J. (1994) [Pubmed]
  8. Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time. Allin, C., Ahmadian, M.R., Wittinghofer, A., Gerwert, K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. Utilization of modified surfactant-associated protein B for delivery of DNA to airway cells in culture. Baatz, J.E., Bruno, M.D., Ciraolo, P.J., Glasser, S.W., Stripp, B.R., Smyth, K.L., Korfhagen, T.R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  10. Infrared evidence that the Schiff base of bacteriorhodopsin is protonated: bR570 and K intermediates. Rothschild, K.J., Marrero, H. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  11. Changes of low-frequency vibrational modes induced by universal 15N- and 13C-isotope labeling in S2/S1 FTIR difference spectrum of oxygen-evolving complex. Kimura, Y., Mizusawa, N., Ishii, A., Yamanari, T., Ono, T.A. Biochemistry (2003) [Pubmed]
  12. The binding sites of quinones in photosynthetic bacterial reaction centers investigated by light-induced FTIR difference spectroscopy: assignment of the QA vibrations in Rhodobacter sphaeroides using 18O- or 13C-labeled ubiquinone and vitamin K1. Breton, J., Burie, J.R., Berthomieu, C., Berger, G., Nabedryk, E. Biochemistry (1994) [Pubmed]
  13. Time-resolved step-scan Fourier transform infrared spectroscopy of the CO adducts of bovine cytochrome c oxidase and of cytochrome bo(3) from Escherichia coli. Bailey, J.A., Tomson, F.L., Mecklenburg, S.L., MacDonald, G.M., Katsonouri, A., Puustinen, A., Gennis, R.B., Woodruff, W.H., Dyer, R.B. Biochemistry (2002) [Pubmed]
  14. Involvement of glutamic acid 278 in the redox reaction of the cytochrome c oxidase from Paracoccus denitrificans investigated by FTIR spectroscopy. Hellwig, P., Behr, J., Ostermeier, C., Richter, O.M., Pfitzner, U., Odenwald, A., Ludwig, B., Michel, H., Mäntele, W. Biochemistry (1998) [Pubmed]
  15. Monofunctional chorismate mutase from Bacillus subtilis: FTIR studies and the mechanism of action of the enzyme. Gray, J.V., Knowles, J.R. Biochemistry (1994) [Pubmed]
  16. DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. Ling, Y., Rios, H.F., Myers, E.R., Lu, Y., Feng, J.Q., Boskey, A.L. J. Bone Miner. Res. (2005) [Pubmed]
  17. The changing face of glucagon fibrillation: structural polymorphism and conformational imprinting. Pedersen, J.S., Dikov, D., Flink, J.L., Hjuler, H.A., Christiansen, G., Otzen, D.E. J. Mol. Biol. (2006) [Pubmed]
  18. Modification of the phylloquinone in the A1 binding site in photosystem I studied using time-resolved FTIR difference spectroscopy and density functional theory. Bandaranayake, K.M., Wang, R., Hastings, G. Biochemistry (2006) [Pubmed]
  19. Optical spectroscopic study of the effects of a single deoxyribose substitution in a ribose backbone: implications in RNA-RNA interaction. Lindqvist, M., Sarkar, M., Winqvist, A., Rozners, E., Strömberg, R., Gräslund, A. Biochemistry (2000) [Pubmed]
  20. Agonists and partial agonists of rhodopsin: retinal polyene methylation affects receptor activation. Vogel, R., Lüdeke, S., Siebert, F., Sakmar, T.P., Hirshfeld, A., Sheves, M. Biochemistry (2006) [Pubmed]
  21. Quantitative characterization of the structure of rhodopsin in disc membrane by means of Fourier transform infrared spectroscopy. Garcia-Quintana, D., Garriga, P., Manyosa, J. J. Biol. Chem. (1993) [Pubmed]
  22. Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice. Anderson, H.C., Sipe, J.B., Hessle, L., Dhanyamraju, R., Atti, E., Camacho, N.P., Millán, J.L., Dhamyamraju, R. Am. J. Pathol. (2004) [Pubmed]
  23. Interactions of phosphate groups of ATP and Aspartyl phosphate with the sarcoplasmic reticulum Ca2+-ATPase: an FTIR study. Liu, M., Krasteva, M., Barth, A. Biophys. J. (2005) [Pubmed]
  24. FTIR imaging of wheat endosperm cell walls in situ reveals compositional and architectural heterogeneity related to grain hardness. Barron, C., Parker, M.L., Mills, E.N., Rouau, X., Wilson, R.H. Planta (2005) [Pubmed]
  25. Sterilization of teeth by gamma radiation. White, J.M., Goodis, H.E., Marshall, S.J., Marshall, G.W. J. Dent. Res. (1994) [Pubmed]
  26. Elastin calcification and its prevention with aluminum chloride pretreatment. Vyavahare, N., Ogle, M., Schoen, F.J., Levy, R.J. Am. J. Pathol. (1999) [Pubmed]
  27. Comparative vibrational spectroscopy of intracellular tau and extracellular collagen I reveals parallels of gelation and fibrillar structure. Juszczak, L.J. J. Biol. Chem. (2004) [Pubmed]
  28. Imaging of collagen and proteoglycan in cartilage sections using Fourier transform infrared spectral imaging. Potter, K., Kidder, L.H., Levin, I.W., Lewis, E.N., Spencer, R.G. Arthritis Rheum. (2001) [Pubmed]
  29. Structural changes of D1 C-terminal alpha-carboxylate during S-state cycling in photosynthetic oxygen evolution. Kimura, Y., Mizusawa, N., Yamanari, T., Ishii, A., Ono, T.A. J. Biol. Chem. (2005) [Pubmed]
  30. Effects of oligomerization and secondary structure on the surface behavior of pulmonary surfactant proteins SP-B and SP-C. Wüstneck, N., Wüstneck, R., Perez-Gil, J., Pison, U. Biophys. J. (2003) [Pubmed]
  31. Induced alpha-helix structure in AF1 of the androgen receptor upon binding transcription factor TFIIF. Kumar, R., Betney, R., Li, J., Thompson, E.B., McEwan, I.J. Biochemistry (2004) [Pubmed]
  32. Differential growth factor control of bone formation through osteoprogenitor differentiation. Chaudhary, L.R., Hofmeister, A.M., Hruska, K.A. Bone (2004) [Pubmed]
  33. Regular intergrowth in the AFI-type crystals: influence on the intracrystalline adsorbate distribution as observed by interference and FTIR-microscopy. Lehmann, E., Chmelik, C., Scheidt, H., Vasenkov, S., Staudte, B., Kärger, J., Kremer, F., Zadrozna, G., Kornatowski, J. J. Am. Chem. Soc. (2002) [Pubmed]
  34. Differential effects of alkyl- and arylguanidines on the stability and reactivity of inducible NOS heme-dioxygen complexes. Moreau, M., Boucher, J.L., Mattioli, T.A., Stuehr, D.J., Mansuy, D., Santolini, J. Biochemistry (2006) [Pubmed]
  35. Expanding the number of stable isomeric structures of the C80 cage: a new fullerene Dy3N@C80. Yang, S., Dunsch, L. Chemistry (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
  36. Reversible immobilization of peptides: surface modification and in situ detection by attenuated total reflection FTIR spectroscopy. Rigler, P., Ulrich, W.P., Hoffmann, P., Mayer, M., Vogel, H. Chemphyschem : a European journal of chemical physics and physical chemistry. (2003) [Pubmed]
  37. Experimental and theoretical investigation of the room-temperature photoluminescence of amorphized Pb(Zr,Ti)O3. Orhan, E., Pontes, F.M., Leite, E.R., Pizani, P.S., Varela, J.A., Longo, E. Chemphyschem : a European journal of chemical physics and physical chemistry. (2005) [Pubmed]
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