Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN10414714 (E)-7-[2-morpholin-4-yl-3- oxo-5-[(4...

Synonyms: AC1O5JQF, AH-23848, LS-74566, AH23848, BRN 4279184, ...

Uski, T.K., Fiddler, G.I. et al., Kopp, U.C. et al., Geoffroy, J. et al.

Kopp, Cicha, Nakamura, Nüsing, Smith, Hökfelt,

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Disease relevance of AH 23848

AH 23848 was ineffective in patients with stable angina but did benefit patients with peripheral vascular disease [1].

High impact information on AH 23848

AH 23848, given according to the same schedule, normalized the blood pressure level [2].
The SP release by butaprost and PGE(2) was similarly blocked by the EP4 receptor antagonist AH-23848 (30 microM) [3].
The effects of the thromboxane-receptor antagonist AH 23848 were investigated on isolated feline basilar arteries (BA) [4].
Further characterization of the contraction-mediating prostanoid receptors in feline cerebral arteries. Effects of the thromboxane-receptor antagonist AH 23848 [4].

References

Preliminary clinical studies with thromboxane synthase inhibitors and thromboxane receptor blockers. A review. Fiddler, G.I., Lumley, P. Circulation (1990) [Pubmed]
Thromboxane A2 and development of genetic hypertension in the Lyon rat strain. Geoffroy, J., Benzoni, D., Vincent, M., Sassard, J. Hypertension (1990) [Pubmed]
Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves. Kopp, U.C., Cicha, M.Z., Nakamura, K., Nüsing, R.M., Smith, L.A., Hökfelt, T. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
Further characterization of the contraction-mediating prostanoid receptors in feline cerebral arteries. Effects of the thromboxane-receptor antagonist AH 23848. Uski, T.K. Acta Physiol. Scand. (1988) [Pubmed]

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