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Chemical Compound Review:

Germacron (3E,7E)-3,7-dimethyl-10- propan-2-ylidene...

Synonyms: Germacrone, SureCN2551615, AC1O5LHN, LS-55947, KB-207314, ...

Deng, C. et al., You, J. et al., Rangelov, A. et al., You, J. et al.

You, Cui, Li, Yong-sheng, Han, Yu,

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High impact information on Germacron

In the present work, microwave-assisted extraction (MAE) followed by headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) was developed for the quantitative analysis of curcumol, curdione and germacrone in Rhizoma Curcuma [1].
Fast determination of curcumol, curdione and germacrone in three species of Curcuma rhizomes by microwave-assisted extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry [1].
A validated new, simple and highly sensitive reversed-phase HPLC method is developed for studying the pharmacokinetics of germacrone after intravenous administration of zedoary turmeric oil (ZTO) oil-in-water microemulsion [2].
Experimental study of essential oils from two varieties of cultivated thyme, sesquiterpene Germacron and diterpene Sclareol for cholagogic and choleretic activity [3].

Biological context of Germacron

Germacrone exhibited linear pharmacokinetics after intravenous administration of ZTO microemulsion to rabbits over the germacrone dose range 3.2-9.6 mg/ml [2].

Analytical, diagnostic and therapeutic context of Germacron

Curcumol, germacrone and curdione are the main active ingredients in a common traditional Chinese medicine (TCM) of Rhizoma Curcuma, and commonly used as the TCM quality control markers [1].
A HPLC method was employed to determine the plasma concentration of Germacrone, an indexical component found in ZTO [4].

References

Fast determination of curcumol, curdione and germacrone in three species of Curcuma rhizomes by microwave-assisted extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry. Deng, C., Ji, J., Li, N., Yu, Y., Duan, G., Zhang, X. Journal of chromatography. A. (2006) [Pubmed]
A HPLC method for the analysis of germacrone in rabbit plasma and its application to a pharmacokinetic study of germacrone after administration of zedoary turmeric oil. You, J., Cui, F.D., Li, Q.P., Yong-sheng, W., Han, X., Yu, Y.W. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2005) [Pubmed]
Experimental study of essential oils from two varieties of cultivated thyme, sesquiterpene Germacron and diterpene Sclareol for cholagogic and choleretic activity. Rangelov, A., Kossev, P., Malakov, P. Folia medica. (1989) [Pubmed]
A novel formulation design about water-insoluble oily drug: preparation of zedoary turmeric oil microspheres with self-emulsifying ability and evaluation in rabbits. You, J., Cui, F.D., Li, Q.P., Han, X., Yu, Y.W., Yang, M.S. International journal of pharmaceutics. (2005) [Pubmed]

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