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Chemical Compound Review

curcumin     (1E,6E)-1,7-bis(4-hydroxy-3- methoxy...

Synonyms: Cucurmin, Gelbwurz, Kurkumin, Turmeric, Curcuma, ...
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Disease relevance of Turmeric yellow


Psychiatry related information on Turmeric yellow


High impact information on Turmeric yellow

  • Suppression of NF-kappaB and STAT3 activation in MM cells by ex vivo treatment with curcumin (diferuloylmethane) resulted in a decrease in adhesion to bone marrow stromal cells, cytokine secretion, and in the viability of cells [13].
  • Curcumin, derived from the rhizome of Curcuma longa L. and having both antioxidant and anti-inflammatory properties, inhibits chemically induced carcinogenesis in the skin, forestomach, and colon when it is administered during initiation and/or postinitiation stages [14].
  • Curcumin, which is a naturally occurring compound, is present in turmeric, possesses both antiinflammatory and antioxidant properties, and has been tested for its chemopreventive properties in skin and forestomach carcinogenesis [15].
  • Topical application of curcumin, the yellow pigment in turmeric and curry, strongly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase activity, DNA synthesis, and tumor promotion in mouse skin (Huang et al., Cancer Res., 48: 5941-5946, 1988) [16].
  • Therefore, we undertook studies to determine the antiarthritic efficacy and mechanism of action of a well-characterized turmeric extract using an animal model of rheumatoid arthritis (RA) [17].

Chemical compound and disease context of Turmeric yellow


Biological context of Turmeric yellow


Anatomical context of Turmeric yellow


Associations of Turmeric yellow with other chemical compounds

  • Other spices, such as saffron, a food colorant; turmeric, a yellow colored spice; tea, either green or black, and flaxseed do contain potent phytochemicals, including carotenoids, curcumins, catechins, lignan respectively, which provide significant protection against cancer [31].
  • Free radical reactions of curumin, a lipid soluble antioxidant from turmeric (Curcuma longa), have been studied with a variety of oxidants using TX 100 micelle as a model membrane [32].
  • Benzenesulfonamide and iminodiacetate (IDA)-conjugated Cu(2+) independently interact at the active site and a peripheral site of carbonic anhydrases, respectively [Banerjee, A. L., Swanson, M., Roy, B. C., Jia, X., Haldar, M. K., Mallik, S., and Srivastava, D. K. (2004) J. Am. Chem. Soc. 126, 10875-10883] [33].
  • OBJECTIVES: Xanthorrhizol, isolated from the methanol extract of Curcuma xanthorrhiza Roxb., was investigated for its anticandidal activity using six Candida species [34].
  • Such undesired effects of oxidative stress have been found to be controlled by the antioxidant and/or anti-inflammatory effects of dietary polyphenols such as curcumin (diferuloylmethane, a principal component of tumeric) and resveratrol (a flavanoid found in red wine) [35].
  • When it was administered to tumor-bearing nude mice, curcumin inhibited growth of PC3 xenografts and enhanced the antitumor effects of gemcitabine and radiation [36].
  • In SKOV3ip1 and HeyA8 tumors, curcumin alone and with docetaxel decreased both proliferation (P < 0.001) and microvessel density (P < 0.001) and increased tumor cell apoptosis (P < 0.05) [37].

Gene context of Turmeric yellow


Analytical, diagnostic and therapeutic context of Turmeric yellow


  1. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Bharti, A.C., Donato, N., Singh, S., Aggarwal, B.B. Blood (2003) [Pubmed]
  2. Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Mukhopadhyay, A., Banerjee, S., Stafford, L.J., Xia, C., Liu, M., Aggarwal, B.B. Oncogene (2002) [Pubmed]
  3. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Sharma, R.A., McLelland, H.R., Hill, K.A., Ireson, C.R., Euden, S.A., Manson, M.M., Pirmohamed, M., Marnett, L.J., Gescher, A.J., Steward, W.P. Clin. Cancer Res. (2001) [Pubmed]
  4. Curcumin prevents and reverses murine cardiac hypertrophy. Li, H.L., Liu, C., de Couto, G., Ouzounian, M., Sun, M., Wang, A.B., Huang, Y., He, C.W., Shi, Y., Chen, X., Nghiem, M.P., Liu, Y., Chen, M., Dawood, F., Fukuoka, M., Maekawa, Y., Zhang, L., Leask, A., Ghosh, A.K., Kirshenbaum, L.A., Liu, P.P. J. Clin. Invest. (2008) [Pubmed]
  5. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. Morimoto, T., Sunagawa, Y., Kawamura, T., Takaya, T., Wada, H., Nagasawa, A., Komeda, M., Fujita, M., Shimatsu, A., Kita, T., Hasegawa, K. J. Clin. Invest. (2008) [Pubmed]
  6. Phase II trial of curcumin in patients with advanced pancreatic cancer. Dhillon, N., Aggarwal, B.B., Newman, R.A., Wolff, R.A., Kunnumakkara, A.B., Abbruzzese, J.L., Ng, C.S., Badmaev, V., Kurzrock, R. Clin. Cancer Res. (2008) [Pubmed]
  7. The potential role of curcumin in patients with monoclonal gammopathy of undefined significance--its effect on paraproteinemia and the urinary N-telopeptide of type I collagen bone turnover marker. Golombick, T., Diamond, T.H., Badmaev, V., Manoharan, A., Ramakrishna, R. Clin. Cancer Res. (2009) [Pubmed]
  8. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Aggarwal, B.B., Sung, B. Trends Pharmacol. Sci. (2009) [Pubmed]
  9. Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway. Weissenberger, J., Priester, M., Bernreuther, C., Rakel, S., Glatzel, M., Seifert, V., Kögel, D. Clin. Cancer Res. (2010) [Pubmed]
  10. Curcumin Treatment Suppresses IKK{beta} Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study. Kim, S.G., Veena, M.S., Basak, S.K., Han, E., Tajima, T., Gjertson, D.W., Starr, J., Eidelman, O., Pollard, H.B., Srivastava, M., Srivatsan, E.S., Wang, M.B. Clin. Cancer Res. (2011) [Pubmed]
  11. Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer's disease. Park, S.Y., Kim, D.S. J. Nat. Prod. (2002) [Pubmed]
  12. Ethanolic Extracts from Curcuma longa Attenuates Behavioral, Immune, and Neuroendocrine Alterations in a Rat Chronic Mild Stress Model. Xia, X., Pan, Y., Zhang, W.Y., Cheng, G., Kong, L.D. Biol. Pharm. Bull. (2006) [Pubmed]
  13. Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Bharti, A.C., Shishodia, S., Reuben, J.M., Weber, D., Alexanian, R., Raj-Vadhan, S., Estrov, Z., Talpaz, M., Aggarwal, B.B. Blood (2004) [Pubmed]
  14. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Kawamori, T., Lubet, R., Steele, V.E., Kelloff, G.J., Kaskey, R.B., Rao, C.V., Reddy, B.S. Cancer Res. (1999) [Pubmed]
  15. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Rao, C.V., Rivenson, A., Simi, B., Reddy, B.S. Cancer Res. (1995) [Pubmed]
  16. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Huang, M.T., Lysz, T., Ferraro, T., Abidi, T.F., Laskin, J.D., Conney, A.H. Cancer Res. (1991) [Pubmed]
  17. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Funk, J.L., Frye, J.B., Oyarzo, J.N., Kuscuoglu, N., Wilson, J., McCaffrey, G., Stafford, G., Chen, G., Lantz, R.C., Jolad, S.D., S??lyom, A.M., Kiela, P.R., Timmermann, B.N. Arthritis Rheum. (2006) [Pubmed]
  18. Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection. De Clercq, E. Medicinal research reviews. (2000) [Pubmed]
  19. Curcumin attenuates DNB-induced murine colitis. Salh, B., Assi, K., Templeman, V., Parhar, K., Owen, D., Gómez-Muñoz, A., Jacobson, K. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  20. Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line. Aratanechemuge, Y., Komiya, T., Moteki, H., Katsuzaki, H., Imai, K., Hibasami, H. Int. J. Mol. Med. (2002) [Pubmed]
  21. Chemical comparison of goldenseal (Hydrastis canadensis L.) root powder from three commercial suppliers. Weber, H.A., Zart, M.K., Hodges, A.E., Molloy, H.M., O'Brien, B.M., Moody, L.A., Clark, A.P., Harris, R.K., Overstreet, J.D., Smith, C.S. J. Agric. Food Chem. (2003) [Pubmed]
  22. A water extract of Curcuma longa L. (Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cells. Koo, B.S., Lee, W.C., Chung, K.H., Ko, J.H., Kim, C.H. Life Sci. (2004) [Pubmed]
  23. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. Bharti, A.C., Donato, N., Aggarwal, B.B. J. Immunol. (2003) [Pubmed]
  24. Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma. Uddin, S., Hussain, A.R., Manogaran, P.S., Al-Hussein, K., Platanias, L.C., Gutierrez, M.I., Bhatia, K.G. Oncogene (2005) [Pubmed]
  25. DNA damage by smoke: protection by turmeric and other inhibitors of ROS. Srinivas, L., Shalini, V.K. Free Radic. Biol. Med. (1991) [Pubmed]
  26. Inhibition of protease-resistant prion protein accumulation in vitro by curcumin. Caughey, B., Raymond, L.D., Raymond, G.J., Maxson, L., Silveira, J., Baron, G.S. J. Virol. (2003) [Pubmed]
  27. Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. Bharti, A.C., Takada, Y., Aggarwal, B.B. J. Immunol. (2004) [Pubmed]
  28. Regulation of mitochondrial and microsomal phospholipid synthesis by liver fatty acid-binding protein. Vancura, A., Haldar, D. J. Biol. Chem. (1992) [Pubmed]
  29. Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor. Giri, R.K., Rajagopal, V., Kalra, V.K. J. Neurochem. (2004) [Pubmed]
  30. Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells. Tomita, M., Kawakami, H., Uchihara, J.N., Okudaira, T., Masuda, M., Takasu, N., Matsuda, T., Ohta, T., Tanaka, Y., Ohshiro, K., Mori, N. Int. J. Cancer (2006) [Pubmed]
  31. Antimicrobial and chemopreventive properties of herbs and spices. Lai, P.K., Roy, J. Current medicinal chemistry. (2004) [Pubmed]
  32. Free radical reactions of curcumin in membrane models. Priyadarsini, K.I. Free Radic. Biol. Med. (1997) [Pubmed]
  33. Spacer-based selectivity in the binding of "two-prong" ligands to recombinant human carbonic anhydrase I. Banerjee, A.L., Eiler, D., Roy, B.C., Jia, X., Haldar, M.K., Mallik, S., Srivastava, D.K. Biochemistry (2005) [Pubmed]
  34. In vitro anticandidal activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. Rukayadi, Y., Yong, D., Hwang, J.K. J. Antimicrob. Chemother. (2006) [Pubmed]
  35. Regulation of inflammation and redox signaling by dietary polyphenols. Rahman, I., Biswas, S.K., Kirkham, P.A. Biochem. Pharmacol. (2006) [Pubmed]
  36. Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Li, M., Zhang, Z., Hill, D.L., Wang, H., Zhang, R. Cancer Res. (2007) [Pubmed]
  37. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Lin, Y.G., Kunnumakkara, A.B., Nair, A., Merritt, W.M., Han, L.Y., Armaiz-Pena, G.N., Kamat, A.A., Spannuth, W.A., Gershenson, D.M., Lutgendorf, S.K., Aggarwal, B.B., Sood, A.K. Clin. Cancer Res. (2007) [Pubmed]
  38. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Shakibaei, M., John, T., Schulze-Tanzil, G., Lehmann, I., Mobasheri, A. Biochem. Pharmacol. (2007) [Pubmed]
  39. Curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (ABCC1). Chearwae, W., Wu, C.P., Chu, H.Y., Lee, T.R., Ambudkar, S.V., Limtrakul, P. Cancer Chemother. Pharmacol. (2006) [Pubmed]
  40. p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. Lutz, S., Freichel-Blomquist, A., Rümenapp, U., Schmidt, M., Jakobs, K.H., Wieland, T. Naunyn Schmiedebergs Arch. Pharmacol. (2004) [Pubmed]
  41. Curcumin derivatives inhibit the formation of Jun-Fos-DNA complex independently of their conserved cysteine residues. Park, C.H., Lee, J.H., Yang, C.H. J. Biochem. Mol. Biol. (2005) [Pubmed]
  42. Turmeric and curcumin modulate the conjugation of 1-naphthol in Caco-2 cells. Naganuma, M., Saruwatari, A., Okamura, S., Tamura, H. Biol. Pharm. Bull. (2006) [Pubmed]
  43. Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells. Fahey, A.J., Adrian Robins, R., Constantinescu, C.S. J. Cell. Mol. Med. (2007) [Pubmed]
  44. Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Wang, D., Veena, M.S., Stevenson, K., Tang, C., Ho, B., Suh, J.D., Duarte, V.M., Faull, K.F., Mehta, K., Srivatsan, E.S., Wang, M.B. Clin. Cancer Res. (2008) [Pubmed]
  45. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Aggarwal, S., Ichikawa, H., Takada, Y., Sandur, S.K., Shishodia, S., Aggarwal, B.B. Mol. Pharmacol. (2006) [Pubmed]
  46. Effect of turmeric and curcumin on BP-DNA adducts. Mukundan, M.A., Chacko, M.C., Annapurna, V.V., Krishnaswamy, K. Carcinogenesis (1993) [Pubmed]
  47. Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells. Beevers, C.S., Li, F., Liu, L., Huang, S. Int. J. Cancer (2006) [Pubmed]
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