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Chemical Compound Review:

Spotless (E)-1-(2,4-dichlorophenyl)- 4,4-dimethyl-2...

Synonyms: Mixor, Diniconazole, Sumi, Sumi-8, Nb (pesticide), ...

Hosokawa, S. et al., Aoyama, Y. et al., Yoshida, Y. et al., Parvez, S.D. et al.

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High impact information on Ortho spotless

However, P-450SG1 showed no lanosterol 14 alpha-demethylase activity and its mode of interaction with diniconazole [(E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-y1)-1- penten-3- o1], a specific inhibitor of P-450(14DM), was fundamentally different from that of P-450(14DM) [1].
These observations suggest that P-450/14DM discriminates enantiomers of diniconazole and the R(-) isomer is more favorably fit for the active site of the cytochrome [2].
Spotless wings (sl) and 2nd-3rd costal spots fused (2-3f) have been mapped on chromosome 2, approximately 79.5 map units apart [3].
The toxicological significance in humans is extremely low and it is unlikely that diniconazole would increase thyroid tumor in humans even if diniconazole were to alter normal thyroid hormone level in humans [4].

Anatomical context of Ortho spotless

Hormonal disregulation mechanism in the rat thyroid tumor induced by diniconazole [4].

References

Isolation and characterization of an altered cytochrome P-450 from a yeast mutant defective in lanosterol 14 alpha-demethylation. Aoyama, Y., Yoshida, Y., Nishino, T., Katsuki, H., Maitra, U.S., Mohan, V.P., Sprinson, D.B. J. Biol. Chem. (1987) [Pubmed]
Stereo-selective interaction of enantiomers of diniconazole, a fungicide, with purified P-450/14DM from yeast. Yoshida, Y., Aoyama, Y., Takano, H., Kato, T. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
Two new mutations and a linkage map of Anopheles stephensi. Parvez, S.D., Akhtar, K., Sakai, R.K. J. Hered. (1985) [Pubmed]
Hormonal disregulation mechanism in the rat thyroid tumor induced by diniconazole. Hosokawa, S., Nakamura, J., Ito, S., Murakami, M., Ineyama, M., Yoshioka, K., Yamada, T., Seki, T., Matsuo, M., Yamada, H. The Journal of toxicological sciences. (1993) [Pubmed]

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