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Chemical Compound Review:

AC1O5NKP (1S,3S,5Z)-5-[(2E)-2- [(1R,3aR,7aR)-1-[(2R)...

Synonyms: LS-176138, 60965-80-2, 1,24-Dihydroxyvitamin D3, 1,24-Dihydroxycholecalciferol, 1alpha,24-Dihydroxyvitamin D3, ...

Komoriya, K. et al., Aoki, T. et al., Okano, M., Russell, R.G., Ohta, T. et al., et al.

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Disease relevance of 1,24-Dihydroxycholecalciferol

A case of subcorneal pustular dermatosis treated with tacalcitol (1alpha,24-dihydroxyvitamin D3) [1].
BACKGROUND: Topical tacalcitol (1alpha,24-dihydroxyvitamin D3) has been demonstrated to produce beneficial clinical effects on epidermo-hyperproliferative disorders such as psoriasis and pityriasis rubra pilaris [2].

High impact information on 1,24-Dihydroxycholecalciferol

In addition, dissociation of migrating keratinocytes was observed when biopsy specimens of the HHD skin lesion were cultured in medium without 1alpha,24-dihydroxyvitamin D3, but inhibition of keratinocyte dissociation was observed in medium containing it [3].
1,25-Dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 suppressed an antibody response to sheep red blood cells (SRBC, T cell-dependent antigen) by murine splenocytes, in concentrations ranging from 10(-10)-10(-7)M [4].
Effect of 1,24-dihydroxyvitamin D3 on proliferation stimulated by epidermal growth factor in cultured mouse epidermal keratinocytes [5].
Effects of 1,24 dihydroxyvitamin D3 and calcitonin on fracture healing in adult rats [6].
These processes are influenced by many factors, the most important of which are parathyroid hormone and the hormones derived from the renal metabolism of vitamin D, notably 1,24-dihydroxyvitamin D3 [7].

Biological context of 1,24-Dihydroxycholecalciferol

1,25-Dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 suppress in vitro antibody response to T cell-dependent antigen [4].

References

A case of subcorneal pustular dermatosis treated with tacalcitol (1alpha,24-dihydroxyvitamin D3). Kawaguchi, M., Mitsuhashi, Y., Kondo, S. J. Dermatol. (2000) [Pubmed]
Assessment of the clinical effect of topical tacalcitol on ichthyoses with retentive hyperkeratosis. Okano, M. Dermatology (Basel) (2001) [Pubmed]
1alpha,24-dihydroxyvitamin D3 (tacalcitol) is effective against Hailey-Hailey disease both in vivo and in vitro. Aoki, T., Hashimoto, H., Koseki, S., Hozumi, Y., Kondo, S. Br. J. Dermatol. (1998) [Pubmed]
1,25-Dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 suppress in vitro antibody response to T cell-dependent antigen. Komoriya, K., Nagata, I., Tsuchimoto, M., Kunisawa, K., Takeshita, T., Naruchi, T. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
Effect of 1,24-dihydroxyvitamin D3 on proliferation stimulated by epidermal growth factor in cultured mouse epidermal keratinocytes. Ohta, T., Mimura, H., Kiyoki, M. Arch. Dermatol. Res. (1996) [Pubmed]
Effects of 1,24 dihydroxyvitamin D3 and calcitonin on fracture healing in adult rats. Lindgren, J.U., Narechania, R.G., McBeath, A.A., Lange, T.A., DeLuca, H.F. Clin. Orthop. Relat. Res. (1981) [Pubmed]
Regulation of calcium metabolism. Russell, R.G. Ann. Clin. Biochem. (1976) [Pubmed]

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