Disease relevance of Skin Diseases, Vesiculobullous

• Pemphigus vulgaris (PV) is an autoimmune bullous skin disease characterized by Abs to the desmosomal cadherin desmoglein-3 [1].
• Thus, this 105-kD lower lamina lucida protein represents a novel autoantigen and this patient's disease represents a novel autoantigen and this patient's disease represents a deep lamina lucida pemphigoid, distinguishable from all other known autoimmune bullous dermatoses [2].
• Herpes gestationis and dermatitis herpetiformis may be bullous skin diseases entirely mediated by the alternate or properdin pathway [3].
• Dapsone-induced motor polyneuropathy. A complication of prolonged treatment of subcorneal pustular dermatosis [4].
• A subcorneal pustular dermatosis and a vesicobullous eruption with the clinical ad histologic features of localized bullous pemphigoid(BP) were observed in a 44-year-old woman with morphea and a recent history of phenytoin sodium-induced toxic epidermal necrolysis [5].

High impact information on Skin Diseases, Vesiculobullous

• Sneddon-Wilkinson disease in a patient with rheumatoid arthritis [6].
• RasGAP-like protein IQGAP1 is expressed by human keratinocytes and recognized by autoantibodies in association with bullous skin disease [7].
• Subcorneal pustular dermatosis associated with rheumatoid arthritis and raised IgA: simultaneous remission of skin and joint involvements with dapsone treatment [8].
• BACKGROUND: We have shown previously that human desmocollin (Dsc) 1 is recognized by IgA autoantibodies of subcorneal pustular dermatosis (SPD) type IgA pemphigus [9].
• BACKGROUND: Dystrophic epidermolysis bullosa (DEB) is a bullous skin disease caused by mutations in the type VII collagen gene (COL7A1) [10].

Chemical compound and disease context of Skin Diseases, Vesiculobullous

• Rapid response of IgA pemphigus of subcorneal pustular dermatosis type to treatment with isotretinoin [11].
• Subcorneal pustular dermatosis and IgA paraproteinaemia: response to both etretinate and PUVA [12].
• Diagnostic value of indirect immunofluorescence on sodium chloride-split skin in differential diagnosis of subepidermal autoimmune bullous dermatoses [13].
• Penicillamine-induced bullous dermatoses [14].
• Letter: Vitamin E treatment of dermolytic bullous dermatoses [15].

Anatomical context of Skin Diseases, Vesiculobullous

• All 10 patients with subcorneal pustular dermatosis type IgA pemphigus were positive against desmocollin 1 expressed on COS-7 cells [16].
• Abnormal fibrinogen degradation products identical with those found in synovial fluid from patients with rheumatoid arthritis were detected in exudates from each of the patients with bullous dermatoses, whereas significantly smaller amounts of fibrinogen antigenic material were detected in fluid obtained by suction [17].

Gene context of Skin Diseases, Vesiculobullous

• Lack of expression of interleukin 8 and RANTES in autoimmune bullous skin diseases [18].
• Auto-Ab against the desmosomal adhesion molecule, desmoglein 3 (Dsg3), are critical in the pathogenesis of this disease, since the transfer of serum IgG Ab reactive with Dsg3 into newborn mice induces a bullous skin disease resembling PV [19].
• Immunoblot analysis using recombinant protein of the 180 kD bullous pemphigoid antigen NC16a domain as an aid to the diagnosis of atypical subepidermal autoimmune bullous skin diseases [20].
• A bullous skin disease patient with autoantibodies against separate epitopes in 1 mol/L sodium chloride split skin [21].
• We show that the LR White postembedded immunogold electronmicroscopy technique is convenient and easily applied to studies of autoimmune bullous skin diseases [22].

Analytical, diagnostic and therapeutic context of Skin Diseases, Vesiculobullous

• We report the case of a patient with a widespread bullous skin disease and linear deposits of IgG and C3 at the dermal-epidermal junction using direct immunofluorescence microscopy [23].
• A patient with IgG-kappa-associated subcorneal pustular dermatosis (Sneddon-Wilkinson disease) refractory to dapsone, etretinate, and plasma exchange was successfully treated with corticosteroids [24].
• Immunofluorescence diagnosis of bullous dermatoses on formalin-fixed tissue sections after antigen retrieval [25].
• A relapse showing striking clinical characteristics of subcorneal pustular dermatosis was treated with dapsone (1 mg/kg/day) followed by ultraviolet B-narrowband (UV-B-NB) phototherapy [26].

References