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Chemical Compound Review:

AC1O5PHW (6R)-6-[(1R,3aR,4E,7aR)-4- [(2Z)-2-[(5R)-3...

Synonyms:

Tanaka, Y. et al., Garel, J.M. et al., Tenenhouse, H.S. et al., Wang, Y.Z. et al., Clemens, T.L. et al.

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Disease relevance of 1,24,25-Trihydroxycholecalciferol

Administration of 1,25-dihydroxycholecalciferol or 1,24,25-trihydroxycholecalciferol to TPTX female rats normalized the basal bone resorption of the fetus whereas injection of 24,25-dihydroxycholecalciferol was without effect [1].

High impact information on 1,24,25-Trihydroxycholecalciferol

Production of 1,24,25-trihydroxyvitamin D3, 24-oxo-1,25-dihydroxyvitamin D3, and 24-oxo-1,23,25-trihydroxyvitamin D3 was twofold greater in mitochondria from mutant Hyp/Y mice than from normal +/Y littermates [2].
Effect of 1,25,28-trihydroxyvitamin D2 and 1,24,25-trihydroxyvitamin D3 on intestinal calbindin-D9K mRNA and protein: is there a correlation with intestinal calcium transport [3]?

Analytical, diagnostic and therapeutic context of 1,24,25-Trihydroxycholecalciferol

Nephrectomy failed to eliminate the conversion of 1,25-dihydroxyvitamin D3 to the 1,24,25-trihydroxyvitamin D3, establishing that the 24-hydroxylase can be demonstrated in at least one organ in addition to kidney in contrast to the 1-hydroxylase [4].
Demonstration of circulating 1,24,25-trihydroxyvitamin D3 in man by radioimmunoassay [5].

References

Basal bone resorption in the rat fetus related to the hormonal status of the mother. Garel, J.M., Rebut-Bonneton, C., Delbarre, F. J. Endocrinol. (1980) [Pubmed]
Increased renal catabolism of 1,25-dihydroxyvitamin D3 in murine X-linked hypophosphatemic rickets. Tenenhouse, H.S., Yip, A., Jones, G. J. Clin. Invest. (1988) [Pubmed]
Effect of 1,25,28-trihydroxyvitamin D2 and 1,24,25-trihydroxyvitamin D3 on intestinal calbindin-D9K mRNA and protein: is there a correlation with intestinal calcium transport? Wang, Y.Z., Li, H., Bruns, M.E., Uskokovic, M., Truitt, G.A., Horst, R., Reinhardt, T., Christakos, S. J. Bone Miner. Res. (1993) [Pubmed]
The 24-hydroxylation of 1,25-dihydroxyvitamin D3. Tanaka, Y., Castillo, L., DeLuca, H.F. J. Biol. Chem. (1977) [Pubmed]
Demonstration of circulating 1,24,25-trihydroxyvitamin D3 in man by radioimmunoassay. Clemens, T.L., Fraher, L.J., Sandler, L.M., O'Riordan, J.L. Clin. Endocrinol. (Oxf) (1982) [Pubmed]

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