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Chemical Compound Review

24,25-dihydroxyvitamin D3     (6R)-6-[(1R,3aR,4E,7aR)-4- [(2Z)-2-[(5S)-5...

Synonyms: CHEMBL47183, CS-0806, HY-76915, LS-144718, LS-187059, ...
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Disease relevance of 24,25-dihydroxyvitamin D3


Psychiatry related information on 24,25-dihydroxyvitamin D3


High impact information on 24,25-dihydroxyvitamin D3


Chemical compound and disease context of 24,25-dihydroxyvitamin D3


Biological context of 24,25-dihydroxyvitamin D3


Anatomical context of 24,25-dihydroxyvitamin D3


Associations of 24,25-dihydroxyvitamin D3 with other chemical compounds


Gene context of 24,25-dihydroxyvitamin D3


Analytical, diagnostic and therapeutic context of 24,25-dihydroxyvitamin D3


  1. Suppressive effects of 24,25-dihydroxycholecalciferol on bone resorption induced by acute bilateral nephrectomy in rats. Pavlovitch, J.H., Cournot-Witmer, G., Bourdeau, A., Balsan, S., Fischer, J.A., Heynen, G. J. Clin. Invest. (1981) [Pubmed]
  2. Effect of 25-hydroxyvitamin D3 on vitamin D metabolites in primary biliary cirrhosis. Kaplan, M.M., Goldberg, M.J., Matloff, D.S., Neer, R.M., Goodman, D.B. Gastroenterology (1981) [Pubmed]
  3. Role of 1,25-dihydroxycholecalciferol in growth-plate cartilage: inhibition of terminal differentiation of chondrocytes in vitro and in vivo. Kato, Y., Shimazu, A., Iwamoto, M., Nakashima, K., Koike, T., Suzuki, F., Nishii, Y., Sato, K. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. Preliminary trials with 24,25-dihydroxyvitamin D3 in dialysis osteomalacia. Hodsman, A.B., Wong, E.G., Sherrard, D.J., Brickman, A.S., Lee, D.B., Singer, F.R., Norman, A.W., Coburn, J.W. Am. J. Med. (1983) [Pubmed]
  5. Three-fold induction of renal 25-hydroxyvitamin D3-24-hydroxylase activity and increased serum 24,25-dihydroxyvitamin D3 levels are correlated with the healing process after chick tibial fracture. Seo, E.G., Norman, A.W. J. Bone Miner. Res. (1997) [Pubmed]
  6. Plasma concentrations of vitamin D metabolites in pubertal girls with anorexia nervosa. Aarskog, D., Aksnes, L., Markestad, T., Trygstad, O. Acta endocrinologica. Supplementum. (1986) [Pubmed]
  7. 1 alpha, 25-Dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta. Weisman, Y., Harell, A., Edelstein, S., David, M., Spirer, Z., Golander, A. Nature (1979) [Pubmed]
  8. Vitamin D supply to the rat fetus and neonate. Clements, M.R., Fraser, D.R. J. Clin. Invest. (1988) [Pubmed]
  9. Regulation of the metabolism of 25-hydroxyvitamin D3 in primary cultures of chick kidney cells. Trechsel, U., Bonjour, J.P., Fleisch, H. J. Clin. Invest. (1979) [Pubmed]
  10. Metabolic bone disease in asymptomatic men after partial gastrectomy with Billroth II anastomosis. Klein, K.B., Orwoll, E.S., Lieberman, D.A., Meier, D.E., McClung, M.R., Parfitt, A.M. Gastroenterology (1987) [Pubmed]
  11. Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3. Yu, X.P., Bellido, T., Manolagas, S.C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  12. Seasonal variation in serum concentrations of parathyroid hormone in elderly people. Lips, P., Hackeng, W.H., Jongen, M.J., van Ginkel, F.C., Netelenbos, J.C. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  13. Metabolism of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 by blood derived macrophages from a patient with alveolar rhabdomyosarcoma during short-term culture and 1 alpha,25-dihydroxyvitamin D3 after long-term culture. Hayes, M.E., Bayley, D., Drayson, M., Freemont, A.J., Denton, J., Davies, M., Mawer, E.B. J. Steroid Biochem. Mol. Biol. (1991) [Pubmed]
  14. Vitamin D metabolism during pregnancy and lactation in the rat. Halloran, B.P., Barthell, E.N., DeLuca, H.F. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  15. Competition by 24,25-dihydroxycholecalciferol in the competitive protein binding radioassay of 25-hydroxycalciferol. Haddad, J.G., Min, C., Walgate, J., Hahn, T. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  16. Involvement of intracellular pH elevation in the effect of 1,25-dihydroxyvitamin D3 on HL-60 cells. Hazav, P., Shany, S., Moran, A., Levy, R. Cancer Res. (1989) [Pubmed]
  17. 1,25-Dihydroxyvitamin D3 receptors and functions in cultured pig kidney cells (LLC PK1). Regulation of 24,25-dihydroxyvitamin D3 production. Colston, K., Feldman, D. J. Biol. Chem. (1982) [Pubmed]
  18. Synthesis in vitro of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 by interferon-gamma-stimulated normal human bone marrow and alveolar macrophages. Reichel, H., Koeffler, H.P., Norman, A.W. J. Biol. Chem. (1987) [Pubmed]
  19. The influence of vitamin D metabolites on the calcification of cartilage matrix and the C-propeptide of type II collagen (chondrocalcin). Hinek, A., Poole, A.R. J. Bone Miner. Res. (1988) [Pubmed]
  20. Enhancement of vasoconstrictor response by a noncalcemic analogue of vitamin D3. Shimosawa, T., Ando, K., Fujita, T. Hypertension (1993) [Pubmed]
  21. Displacement potency of vitamin D2 analogs in competitive protein-binding assays for 25-hydroxyvitamin D3, 24,25-dihydroxyvitamin D3, and 1,25-dihydroxyvitamin D3. Jones, G., Byrnes, B., Palma, F., Segev, D., Mazur, Y. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  22. The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading. Halloran, B.P., Bikle, D.D., Wronski, T.J., Globus, R.K., Levens, M.J., Morey-Holton, E. Endocrinology (1986) [Pubmed]
  23. Isolation, identification, and biological activity of 25-hydroxy-24-oxovitamin D3: a new metabolite of vitamin D3 generated by in vitro incubations with kidney homogenates. Takasaki, Y., Suda, T., Yamada, S., Takayama, H., Nishii, Y. Biochemistry (1981) [Pubmed]
  24. Evidence for 24,25-dihydroxycholecalciferol receptors in long bones of newborn rats. Sömjen, D., Sömjen, G.J., Weisman, Y., Binderman, I. Biochem. J. (1982) [Pubmed]
  25. Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia. Yamazaki, Y., Okazaki, R., Shibata, M., Hasegawa, Y., Satoh, K., Tajima, T., Takeuchi, Y., Fujita, T., Nakahara, K., Yamashita, T., Fukumoto, S. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  26. Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D. St-Arnaud, R., Arabian, A., Travers, R., Barletta, F., Raval-Pandya, M., Chapin, K., Depovere, J., Mathieu, C., Christakos, S., Demay, M.B., Glorieux, F.H. Endocrinology (2000) [Pubmed]
  27. Plasma 24,25-dihydroxyvitamin D3 concentrations in X-linked hypophosphatemic mice: studies using mass fragmentographic and radioreceptor assays. Cunningham, J., Coldwell, R.D., Jones, G., Tenenhouse, H.S., Trafford, D.J., Makin, H.L. J. Bone Miner. Res. (1990) [Pubmed]
  28. Use of oral calcium loading to characterize the hypercalciuria of young insulin-dependent diabetics. Witt, M.F., White, N.H., Santiago, J.V., Seino, Y., Avioli, L.V. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  29. Vitamin D metabolites change the phenotype of monoblastic U937 cells. Dodd, R.C., Cohen, M.S., Newman, S.L., Gray, T.K. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  30. Metabolic consequences of oral administration of 24,25-dihydroxycholecalciferol to uremic dogs. Canterbury, J.M., Gavellas, G., Bourgoignie, J.J., Reiss, E. J. Clin. Invest. (1980) [Pubmed]
  31. End-organ resistance to 1,25-dihydroxycholecalciferol. Liberman, U.A., Samuel, R., Halabe, A., Kauli, R., Edelstein, S., Weisman, Y., Papapoulos, S.E., Clemens, T.L., Fraher, L.J., O'Riordan, J.L. Lancet (1980) [Pubmed]
  32. 25-Hydroxyvitamin D3-24-hydroxylase in rat kidney mitochondria. Pedersen, J.I., Shobaki, H.H., Holmberg, I., Bergseth, S., Björkhem, I. J. Biol. Chem. (1983) [Pubmed]
  33. Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines. Miller, G.J., Stapleton, G.E., Hedlund, T.E., Moffat, K.A. Clin. Cancer Res. (1995) [Pubmed]
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