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Disease relevance of Nephrectomy


Psychiatry related information on Nephrectomy


High impact information on Nephrectomy

  • Of 21 transplants with the lesion, nine required nephrectomy by one month, and one-month serum creatinine was less than 2.0 mg per deciliter in only three of the remaining 12 transplants [9].
  • Circulating angiotensin II and adrenal receptors after nephrectomy [10].
  • Male F1 New Zealand Black X New Zealand White mice, which spontaneously develop immune complex renal disease, underwent unilateral nephrectomy at 3 months of age and were compared with sham-operated controls [11].
  • By a weighted scoring system for analysis of differential renal-vein and peripheral renin levels, 70% (16 of 23) of these patients did not give scores predictive of cure by nephrectomy [12].
  • We performed either subtotal nephrectomy (N) or sham operations in WT, leptin receptor-deficient (db/db), and MC4-R knockout (MC4-RKO) mice [13].

Chemical compound and disease context of Nephrectomy


Biological context of Nephrectomy


Anatomical context of Nephrectomy

  • To document the induction of tolerance, recipients with islet xenografts surviving > 100 days were made diabetic again by STZ (thymus and liver) or nephrectomy (kidney capsule) and received a second transplant of 150 fresh WF islets in the kidney capsule [24].
  • To evaluate the role of the kidney in this increase in ET, another group (Group III, ACC + INDO + NEPH; N = 6) was investigated in the presence of prostaglandin inhibition, and bilateral renal artery clamping was performed 30 min before ACC and maintained throughout the protocol to simulate nephrectomy [25].
  • Parathyroid glands were microdissected from control and 5/6 nephrectomy rats and analyzed for PTH mRNA and control genes, and the nuclei were used for nuclear run-on experiments [26].
  • To evaluate the effects of these interventions on the growth plate, weanling rats underwent sham nephrectomy (Control, n = 10) and 5/6 nephrectomy (Nx) [27].
  • The continued critical importance of lymph node sampling in conjunction with nephrectomy for Wilms tumor is also established [28].

Associations of Nephrectomy with chemical compounds

  • The increased water transport in response to (Sar1 Leu8)-AII is not secondary to enhanced renal renin release, as the analog also stimulated jejunal transport in the presence of captopril and after bilateral nephrectomy [29].
  • Dietary acid load was reduced in 1 3/4-nephrectomized rats by dietary supplementation with sodium bicarbonate (NaHCO3), while control rats, paired for serum creatinine after 1 3/4 nephrectomy, were supplemented with equimolar sodium chloride [30].
  • The effect of administration of N-desulfated/acetylated heparin, almost completely devoid of anticoagulant activity, on the progression of renal disease was examined in rats with 13/4 nephrectomy [31].
  • However, treatment with actinomycin D (0.12 mg/kg) prevented the increased Na+-H+ activity as well as the increased renal mass and GFR noted 24 h after unilateral nephrectomy [32].
  • Choline kinase activity increased by 27% (P less than 0.001) in 28-day-old rats when renal growth was stimulated by contralateral nephrectomy; the increase occurred within 2 h after surgery [33].

Gene context of Nephrectomy

  • Groups of six rats were subjected to 5/6 nephrectomy and received renal arterial injection of a doxycycline-regulated Smad7 gene or control empty vector using an ultrasound-microbubble-mediated system [34].
  • Intrarenal insulin-like growth factor-1 axis after unilateral nephrectomy in rat [35].
  • For examining this issue, beginning 2 wk after subtotal nephrectomy, rats received a continuous infusion of recombinant HGF, neutralization of endogenous HGF by daily injection of an anti-HGF antibody, or preimmune IgG for an additional 2 wk [36].
  • Significantly, the PSA levels fell to undetectable after nephrectomy [37].
  • Reverse transcription (RT)-PCR on 20 tumor nephrectomy samples revealed that hTR was constitutively expressed both in cancer and normal tissue samples, independent of the telomerase activity status [38].

Analytical, diagnostic and therapeutic context of Nephrectomy


  1. Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin-4. Obiri, N.I., Hillman, G.G., Haas, G.P., Sud, S., Puri, R.K. J. Clin. Invest. (1993) [Pubmed]
  2. Myoblast transfer of human erythropoietin gene in a mouse model of renal failure. Hamamori, Y., Samal, B., Tian, J., Kedes, L. J. Clin. Invest. (1995) [Pubmed]
  3. Role of atrial natriuretic peptide in adaptation of sodium excretion with reduced renal mass. Smith, S., Anderson, S., Ballermann, B.J., Brenner, B.M. J. Clin. Invest. (1986) [Pubmed]
  4. Effects of hepatectomy, nephrectomy, and nephrectomy/uremia on the metabolism of parathyroid hormone in the rat. Segre, G.V., D'Amour, P., Hultman, A., Potts, J.T. J. Clin. Invest. (1981) [Pubmed]
  5. Early enhancement of fluid transport in rabbit proximal straight tubules after loss of contralateral renal excretory function. Tabei, K., Levenson, D.J., Brenner, B.M. J. Clin. Invest. (1983) [Pubmed]
  6. Serum prolactin levels and prolactin binding activity in adrenals and kidneys of male rats after dehydration, salt loading, and unilateral nephrectomy. Marshall, S., Gelato, M., Meites, J. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
  7. Graft failure and graft nephrectomy without severe complications. Hansen, B.L., Rohr, N., Svendsen, V., Birkeland, S.A. Nephrol. Dial. Transplant. (1987) [Pubmed]
  8. Influence of dietary polyunsaturated fatty acids on renal & aortic prostaglandin synthesis in 1 kidney 1 clip Goldblatt hypertensive rats. Mahoney, D., Croft, K., Beilin, L.J. Prostaglandins (1983) [Pubmed]
  9. Perfusion nephropathy in human transplants. Spector, D., Limas, C., Frost, J.L., Zachary, J.B., Sterioff, S., Williams, G.M., Rolley, R.T., Sadler, J.H. N. Engl. J. Med. (1976) [Pubmed]
  10. Circulating angiotensin II and adrenal receptors after nephrectomy. Aguilera, G., Schirar, A., Baukal, A., Catt, K.J. Nature (1981) [Pubmed]
  11. Unilateral nephrectomy: effect on survival in NZB/NZW mice. Beyer, M.M., Steinberg, A.D., Nicastri, A.D., Friedman, E.A. Science (1977) [Pubmed]
  12. Hypertension and unilateral parenchymal renal disease. Evidence for abnormal vasoconstriction-volume interaction. Vaughan, E.D., Bühler, F.R., Laragh, J.H., Sealey, J.E., Gavras, H., Baer, L. JAMA (1975) [Pubmed]
  13. Role of leptin and melanocortin signaling in uremia-associated cachexia. Cheung, W., Yu, P.X., Little, B.M., Cone, R.D., Marks, D.L., Mak, R.H. J. Clin. Invest. (2005) [Pubmed]
  14. Altered renin release and propranolol potentiation of vasodilatory drug hypotension. Pettinger, W.A., Keeton, K. J. Clin. Invest. (1975) [Pubmed]
  15. Suppressive effects of 24,25-dihydroxycholecalciferol on bone resorption induced by acute bilateral nephrectomy in rats. Pavlovitch, J.H., Cournot-Witmer, G., Bourdeau, A., Balsan, S., Fischer, J.A., Heynen, G. J. Clin. Invest. (1981) [Pubmed]
  16. Reversal of changes in myocardial beta-receptors and inotropic responsiveness with regression of cardiac hypertrophy in renal hypertensive rats (RHR). Ayobe, M.H., Tarazi, R.C. Circ. Res. (1984) [Pubmed]
  17. Pharmacologic treatment of hyperlipidemia reduces glomerular injury in rat 5/6 nephrectomy model of chronic renal failure. Kasiske, B.L., O'Donnell, M.P., Garvis, W.J., Keane, W.F. Circ. Res. (1988) [Pubmed]
  18. Phase II trial of vinblastine, ifosfamide, and gallium combination chemotherapy in metastatic urothelial carcinoma. Einhorn, L.H., Roth, B.J., Ansari, R., Dreicer, R., Gonin, R., Loehrer, P.J. J. Clin. Oncol. (1994) [Pubmed]
  19. Effect of beta-adrenergic blockade on plasma-renin activity and intractable hypertension in patients receiving regular dialysis treatment. Moore, S.B., Goodwin, F.J. Lancet (1976) [Pubmed]
  20. Role of tissue renin in the regulation of aldosterone biosynthesis in the adrenal cortex of nephrectomized rats. Volpe, M., Gigante, B., Enea, I., Porcellini, A., Russo, R., Lee, M.A., Magri, P., Condorelli, G., Savoia, C., Lindpaintner, K., Rubattu, S. Circ. Res. (1997) [Pubmed]
  21. 5-Bromodeoxyuridine-induced carcinogenesis and its modification by persistent estrus syndrome, unilateral nephrectomy, and X-irradiation in rats. Napalkov, N.P., Anisimov, V.N., Likhachev, A.J., Tomatis, L. Cancer Res. (1989) [Pubmed]
  22. Prostacyclin and pathogenesis of hemodynamic abnormalities of diabetic ketoacidosis in rats. Quyyumi, A.A., Iaffaldano, R., Guerrero, J.L., Ryan, C.A., Powell, W.J., Axelrod, L. Diabetes (1989) [Pubmed]
  23. Acute unilateral nephrectomy elicits a specific increase in plasma of peptides derived from the N-terminal region of proopiomelanocortin. Qiu, C., Valentin, J.P., Chen, X.W., Wiedemann, E., Humphreys, M.H. J. Am. Soc. Nephrol. (1992) [Pubmed]
  24. Induction of tolerance to islet xenografts in a concordant rat-to-mouse model. Goss, J.A., Nakafusa, Y., Finke, E.H., Flye, M.W., Lacy, P.E. Diabetes (1994) [Pubmed]
  25. Endothelin in a model of acute ischemic renal dysfunction: modulating action of atrial natriuretic factor. Sandok, E.K., Lerman, A., Stingo, A.J., Perrella, M.A., Gloviczki, P., Burnett, J.C. J. Am. Soc. Nephrol. (1992) [Pubmed]
  26. Mechanism of increased parathyroid hormone mRNA in experimental uremia: roles of protein RNA binding and RNA degradation. Yalcindag, C., Silver, J., Naveh-Many, T. J. Am. Soc. Nephrol. (1999) [Pubmed]
  27. Effects of thyroparathyroidectomy, exogenous calcium, and short-term calcitriol therapy on the growth plate in renal failure. Sanchez, C.P., He, Y.Z. J. Am. Soc. Nephrol. (2003) [Pubmed]
  28. Surgery-related factors and local recurrence of Wilms tumor in National Wilms Tumor Study 4. Shamberger, R.C., Guthrie, K.A., Ritchey, M.L., Haase, G.M., Takashima, J., Beckwith, J.B., D'Angio, G.J., Green, D.M., Breslow, N.E. Ann. Surg. (1999) [Pubmed]
  29. Interactions between angiotensin peptides and the sympathetic nervous system mediating intestinal sodium and water absorption in the rat. Levens, N.R., Peach, M.J., Carey, R.M. J. Clin. Invest. (1981) [Pubmed]
  30. Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3. Nath, K.A., Hostetter, M.K., Hostetter, T.H. J. Clin. Invest. (1985) [Pubmed]
  31. N-desulfated/acetylated heparin ameliorates the progression of renal disease in rats with subtotal renal ablation. Purkerson, M.L., Tollefsen, D.M., Klahr, S. J. Clin. Invest. (1988) [Pubmed]
  32. Adaptation of Na+-H+ exchange in renal microvillus membrane vesicles. Role of dietary protein and uninephrectomy. Harris, R.C., Seifter, J.L., Brenner, B.M. J. Clin. Invest. (1984) [Pubmed]
  33. Choline pathways during normal and stimulated renal growth in rats. Bean, G.H., Lowenstein, L.M. J. Clin. Invest. (1978) [Pubmed]
  34. Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney. Hou, C.C., Wang, W., Huang, X.R., Fu, P., Chen, T.H., Sheikh-Hamad, D., Lan, H.Y. Am. J. Pathol. (2005) [Pubmed]
  35. Intrarenal insulin-like growth factor-1 axis after unilateral nephrectomy in rat. Fervenza, F.C., Tsao, T., Hsu, F., Rabkin, R. J. Am. Soc. Nephrol. (1999) [Pubmed]
  36. Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES. Gong, R., Rifai, A., Tolbert, E.M., Biswas, P., Centracchio, J.N., Dworkin, L.D. J. Am. Soc. Nephrol. (2004) [Pubmed]
  37. A prostate-specific antigen-like protein associated with renal cell carcinoma in women. Clements, J., Ward, G., Kaushal, A., Hi, S.I., Kennett, C., Nicol, D. Clin. Cancer Res. (1997) [Pubmed]
  38. Expression of the human telomerase reverse transcriptase is not related to telomerase activity in normal and malignant renal tissue. Rohde, V., Sattler, H.P., Bund, T., Bonkhoff, H., Fixemer, T., Bachmann, C., Lensch, R., Unteregger, G., Stoeckle, M., Wullich, B. Clin. Cancer Res. (2000) [Pubmed]
  39. Benefits of removal of native kidneys in hypertension after renal transplantation. Curtis, J.J., Luke, R.G., Diethelm, A.G., Whelchel, J.D., Jones, P. Lancet (1985) [Pubmed]
  40. Prevention by vagotomy or atropine administration of the hemodynamic changes occurring after acute unilateral nephrectomy in the dog. Humphreys, M.H., Ayus, J.C., Stanton, C.J. Circ. Res. (1980) [Pubmed]
  41. Collagen metabolism is markedly altered in the hypertrophic cartilage of growth plates from rats with growth impairment secondary to chronic renal failure. Alvarez, J., Balbín, M., Fernández, M., López, J.M. J. Bone Miner. Res. (2001) [Pubmed]
  42. Studies of plasma aldosterone in anephric people: evidence for the fundamental role of the renin system in maintaining aldosterone secretion. Sealey, J.E., White, R.P., Laragh, J.H., Case, D.B., Rubin, A.L. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  43. Mechanisms by which nephrectomy stimulates adrenal renin. Baba, K., Doi, Y., Franco-Saenz, R., Mulrow, P.J. Hypertension (1986) [Pubmed]
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