Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Arazine (2S)-2-acetamido-3-[(2E,6E)- 3,7,11...

Synonyms: N-AFC, AFC Medirepair, CHEMBL1555989, BSPBio_001384, AFC cpd, ...

Pillinger, M.H. et al., Volker, C. et al., Marom, M. et al., Huzoor-Akbar, n.u.l.l. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on N-acetyl-S-farnesylcysteine

We have previously shown that the prenylcysteine analog N-acetyl-S-trans,trans-farnesyl-L-cysteine (AFC) inhibits carboxyl methylation of these proteins in human platelets [1].
Inhibition of the PPMTase by FTS in homogenates or membranes of a variety of tissues and cell lines is inferred from a block in the methylation of exogenously added substrates such as N-acetyl-S-trans,trans-farnesyl-L-cysteine and of endogenous substrates including small GTP-binding proteins [2].
N-Acetyl-S-trans,trans-farnesyl-L-cysteine (AFC) and N-acetyl-S-all-trans-geranylgeranyl-L-cysteine (AGGC) were effective substrates for neutrophil prenylcysteine-directed methyltransferase; Vmax values for AFC and AGGC (16.4 and 22.1 pmol of methylated/mg protein/min, respectively) are among the highest yet reported [3].
Small molecule prenylcysteine derivatives with either the C15 or C20 modification, such as N-acetyl-S-trans,trans-farnesyl-L-cysteine (AFC), S-trans,trans-farnesylthiopropionate (FTP), as well as the corresponding geranylgeranyl derivatives (AGGC and GGTP) are substrates for the carboxyl methyltransferase [4].

References

Protein prenylcysteine analog inhibits agonist-receptor-mediated signal transduction in human platelets. Huzoor-Akbar, n.u.l.l., Wang, W., Kornhauser, R., Volker, C., Stock, J.B. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid. Marom, M., Haklai, R., Ben-Baruch, G., Marciano, D., Egozi, Y., Kloog, Y. J. Biol. Chem. (1995) [Pubmed]
Characterization of a plasma membrane-associated prenylcysteine-directed alpha carboxyl methyltransferase in human neutrophils. Pillinger, M.H., Volker, C., Stock, J.B., Weissmann, G., Philips, M.R. J. Biol. Chem. (1994) [Pubmed]
A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. Volker, C., Lane, P., Kwee, C., Johnson, M., Stock, J. FEBS Lett. (1991) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share