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Chemical Compound Review:

olivanic acid 3-[(E)-2- aminoethenyl]sulfanyl-6-(1...

Synonyms: Olivanic acids, AC1O5PMB, MM 4550, MM 13902, MM 17880, ...

Basker, M.J. et al., Basker, M.J. et al., Charnas, R.L. et al., Easton, C.J. et al., Basker, M.J. et al., et al.

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Disease relevance of Olivanic acids

Inhibition of the RTEM beta-lactamase from Escherichia coli. Interaction of enzyme with derivatives of olivanic acid [1].
The detection of members of the olivanic acid family in Streptomyces gedanensis [2].
The carbapenem antibiotics, which include the olivanic acids and the thienamycins, have a broad-spectrum of antibacterial activity but only thienamycin itself shows appreciable activity against Pseudomonas aeruginosa [3].
The compounds with an (8S) hydroxyethyl substituent and cis-orientated beta-lactam protons, MM 22380 and MM 22382, and their sulphate esters, MM 17880 and MM 123902, are potent antibiotic with MIC values against Gram-positive and Gram-negative bacteria in the range 0.1 3.1 microgram/ml [4].

High impact information on Olivanic acids

Inhibition of the RTEM beta-lactamase from Escherichia coli. Interaction of the enzyme with derivatives of olivanic acid [5].
The interaction of the RTEM beta-lactamase with two derivatives of olivanic acid has been studied [1].
The preparation of mutual pro-drugs of the olivanic acids and an inhibitor of the renal dipeptidase enzyme is described [6].

Analytical, diagnostic and therapeutic context of Olivanic acids

Similar findings were observed also in human volunteers given MM 13902 [3].

References

Inhibition of the RTEM beta-lactamase from Escherichia coli. Interaction of enzyme with derivatives of olivanic acid. Charnas, R.L., Knowles, J.R. Biochemistry (1981) [Pubmed]
The detection of members of the olivanic acid family in Streptomyces gedanensis. Box, S.J., Hanscomb, G., Spear, S.R. J. Antibiot. (1981) [Pubmed]
Properties of MM 13902 and other carbapenem antibiotics in vitro and in vivo. Basker, M.J., Boon, R.J., Box, S.J., Prestige, E.A., Smith, G.M., Spear, S.R. J. Antibiot. (1983) [Pubmed]
Comparative antibacterial properties in vitro of seven olivanic acid derivatives: MM 4550, MM 13902, MM 17880, MM 22380, MM 22381, MM 22382 and MM 22383. Basker, M.J., Boon, R.J., Hunter, P.A. J. Antibiot. (1980) [Pubmed]
Inhibition of the RTEM beta-lactamase from Escherichia coli. Interaction of the enzyme with derivatives of olivanic acid. Easton, C.J., Knowles, J.R. Biochemistry (1982) [Pubmed]
Mutual pro-drugs of the olivanic acids and renal dipeptidase inhibitors. Basker, M.J., Coulton, S., Southgate, R. J. Antibiot. (1985) [Pubmed]

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