Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1O5QJP (5E,8R,9Z,11Z,14Z)-8- hydroperoxyicosa-5,9...

Synonyms: 8-Hpete, 100896-35-3

Andrianarison, R.H. et al., Steel, D.J. et al.

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High impact information on 8-Hpete

Arachidonic acid is converted to (8R)-hydroperoxyeicosa-5,9,11, 14-tetraenoic acid (8-HPETE) during incubations with homogenates of the central nervous system of the marine mollusc, Aplysia californica [1].
When arachidonic acid was incubated with Lupinus Albus lipoxygenase, a trienoic fatty acid, 8,15-dihydroperoxy-5,9,11,13-eicosatetraenoic acid was formed in addition to the three HPETEs, 15-HPETE, 8-HPETE and 5-HPETE [2].

References

Identification of an 8-lipoxygenase pathway in nervous tissue of Aplysia californica. Steel, D.J., Tieman, T.L., Schwartz, J.H., Feinmark, S.J. J. Biol. Chem. (1997) [Pubmed]
Positional specificity of a Lupinus albus lipoxygenase in relation to enzyme concentration and effect of a double dioxygenation product of arachidonic acid. Andrianarison, R.H., Tixier, M., Beneytout, J.L. Biochem. Biophys. Res. Commun. (1990) [Pubmed]

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