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Chemical Compound Review

CHEMBL16997     (E)-3-[4-(2,6-dioxo-1,3- dipropyl-7H-purin...

Synonyms: BW-A1433, SureCN6555021, BWA1433, CHEBI:118691, AC1O5QYB, ...
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Disease relevance of BW-A1433

  • In addition, BW-A1433 shortened the Wenckebach cycle length from 163 +/- 2 to 153 +/- 2 during normoxia and from 172 +/- 3 to 164 +/- 4 during mild hypoxia [1].
  • The adenosine receptor antagonist BW-A1433 (50 microM) decreased functional recovery following ischemia in A(3)AR(-/-) but not in wild-type hearts [2].

High impact information on BW-A1433


  1. Atrioventricular nodal accommodation in isolated guinea pig hearts: physiological significance and role of adenosine. Jenkins, J.R., Belardinelli, L. Circ. Res. (1988) [Pubmed]
  2. Targeted deletion of A(3) adenosine receptors improves tolerance to ischemia-reperfusion injury in mouse myocardium. Cerniway, R.J., Yang, Z., Jacobson, M.A., Linden, J., Matherne, G.P. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  3. Role of adenosine in the depolarization of hypoxic hamster diaphragm membrane in vitro. Esau, S.A. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  4. Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution. Linden, J., Taylor, H.E., Robeva, A.S., Tucker, A.L., Stehle, J.H., Rivkees, S.A., Fink, J.S., Reppert, S.M. Mol. Pharmacol. (1993) [Pubmed]
  5. Arteriolar constriction in skeletal muscle during vascular stunning: role of mast cells. Keller, M.W. Am. J. Physiol. (1997) [Pubmed]
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