Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

CHEMBL16997 (E)-3-[4-(2,6-dioxo-1,3- dipropyl-7H-purin...

Synonyms: BW-A1433, SureCN6555021, BWA1433, CHEBI:118691, AC1O5QYB, ...

Linden, J. et al., Jenkins, J.R. et al., Cerniway, R.J. et al., Esau, S.A., Keller, M.W.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BW-A1433

In addition, BW-A1433 shortened the Wenckebach cycle length from 163 +/- 2 to 153 +/- 2 during normoxia and from 172 +/- 3 to 164 +/- 4 during mild hypoxia [1].
The adenosine receptor antagonist BW-A1433 (50 microM) decreased functional recovery following ischemia in A(3)AR(-/-) but not in wild-type hearts [2].

High impact information on BW-A1433

BW A1433 (3 x 10(-7)) also restored the membrane potential of hypoxic muscle fibers from -72 +/- 1 mV to -79 +/- 1 mV (p < 0.001) [3].
Agonists reduce forskolin-stimulated cAMP accumulation in Chinese hamster ovary cells stably transfected with recombinant sheep A3 adenosine receptors; the reduction is blocked by BW-A1433 but not by 8-cyclopentyl-1,3-dipropylxanthine [4].
Adenosine A3-antagonist BW-A1433 abolished constriction [5].

References

Atrioventricular nodal accommodation in isolated guinea pig hearts: physiological significance and role of adenosine. Jenkins, J.R., Belardinelli, L. Circ. Res. (1988) [Pubmed]
Targeted deletion of A(3) adenosine receptors improves tolerance to ischemia-reperfusion injury in mouse myocardium. Cerniway, R.J., Yang, Z., Jacobson, M.A., Linden, J., Matherne, G.P. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
Role of adenosine in the depolarization of hypoxic hamster diaphragm membrane in vitro. Esau, S.A. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution. Linden, J., Taylor, H.E., Robeva, A.S., Tucker, A.L., Stehle, J.H., Rivkees, S.A., Fink, J.S., Reppert, S.M. Mol. Pharmacol. (1993) [Pubmed]
Arteriolar constriction in skeletal muscle during vascular stunning: role of mast cells. Keller, M.W. Am. J. Physiol. (1997) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share