Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1O5RF5 (2S)-2-amino-3-[(2E,6E,10E)- 3,7,11,15...

Synonyms:

Volker, C. et al., Zhang, L. et al., Epstein, W.W. et al., Beigneux, A. et al.

Beigneux, Withycombe, Digits, Tschantz, Weinbaum, Griffey, Bergo, Casey, Young,

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High impact information on Geranylgeranylcysteine

Prenylated proteins: synthesis of geranylgeranylcysteine and identification of this thioether amino acid as a component of proteins in CHO cells [1].
These studies revealed a striking accumulation of both farnesylcysteine and geranylgeranylcysteine in the brain and liver of Pcly-/- mice [2].
Purified prenylcysteine lyase shows similar kinetics in utilization of both farnesylcysteine and geranylgeranylcysteine as substrates, although Vmax is 2-fold higher with the former compound [3].
Saccharomyces cerevisiae ste14 mutants that lack RAS and a-factor carboxyl methyltransferase activity are also unable to methylate farnesyl and geranylgeranylcysteine derivatives [4].
Finally, AGGC is even more effective than AFC as an inhibitor of Ras carboxyl methylation, despite the fact that Ras is methylated at a farnesylcysteine rather than a geranylgeranylcysteine residue [4].

References

Prenylated proteins: synthesis of geranylgeranylcysteine and identification of this thioether amino acid as a component of proteins in CHO cells. Epstein, W.W., Lever, D.C., Rilling, H.C. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. Beigneux, A., Withycombe, S.K., Digits, J.A., Tschantz, W.R., Weinbaum, C.A., Griffey, S.M., Bergo, M., Casey, P.J., Young, S.G. J. Biol. Chem. (2002) [Pubmed]
Isolation and characterization of a prenylcysteine lyase from bovine brain. Zhang, L., Tschantz, W.R., Casey, P.J. J. Biol. Chem. (1997) [Pubmed]
A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. Volker, C., Lane, P., Kwee, C., Johnson, M., Stock, J. FEBS Lett. (1991) [Pubmed]

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