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Chemical Compound Review:

AC1O5RW5 (2Z,4E,6Z,8E)-N-(4- methoxyphenyl)-3,7...

Synonyms: 4-MPR, 4MPR, 79965-10-9, N-4-Methoxyphenylretinamide, N-(4-Methoxyphenyl)retinamide, ...

Appierto, V. et al., Kazmi, S.M. et al., Dimitrov, N.V. et al.

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Disease relevance of AIDS210897

Similar to RA, both 4-HPR and its active metabolite N-(4-methoxyphenyl)retinamide (4-MPR) effectively impeded the growth of MCF7 and T-47D human breast cancer cell lines, except that 4-HPR also inhibited the proliferation of RA-resistant BT-20 cells [1].

High impact information on AIDS210897

Increase in plasma HPR was accompanied by an even higher increase in the metabolite N-(4-methoxyphenyl)-all-trans-retinamide (MPR) [2].

Associations of AIDS210897 with other chemical compounds

The cells (A2780/HPR) did not show cross-resistance to the synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) and were not sensitive, similarly to the parent line, to all-trans-retinoic acid, 13-cis-retinoic acid or N-(4-methoxyphenyl)retinamide [3].

References

Comparison of N-(4-hydroxyphenyl)retinamide and all-trans-retinoic acid in the regulation of retinoid receptor-mediated gene expression in human breast cancer cell lines. Kazmi, S.M., Plante, R.K., Visconti, V., Lau, C.Y. Cancer Res. (1996) [Pubmed]
Alteration of retinol-binding-protein concentrations by the synthetic retinoid fenretinide in healthy human subjects. Dimitrov, N.V., Meyer, C.J., Perloff, M., Ruppenthal, M.M., Phillipich, M.J., Gilliland, D., Malone, W., Minn, F.L. Am. J. Clin. Nutr. (1990) [Pubmed]
Decrease in drug accumulation and in tumour aggressiveness marker expression in a fenretinide-induced resistant ovarian tumour cell line. Appierto, V., Cavadini, E., Pergolizzi, R., Cleris, L., Lotan, R., Canevari, S., Formelli, F. Br. J. Cancer (2001) [Pubmed]

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