The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Necic acid     (2R,3R,5Z)-5-ethylidene-2- hydroxy-2,3...

Synonyms: AC1O5UBF, 13588-16-4
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Necic acid

  • In the heliotridine series, the configuration of the necic acid has a pronounced effect on the site selectivity (C-7 vs C-9) in esterification with carbodiimidazole [1].
  • 2. The dehydroalkaloids are highly reactive and either bind covalentely to tissue nucleophiles or are hydrolysed to the more stable pyrrole, (R,S)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP), and the corresponding necic acid [2].

Associations of Necic acid with other chemical compounds

  • Firstly, the necine bases are structurally modified and either before or after this modification are converted into their O(9)-esters by esterification with one of the stereoisomers of 2,3-dihydroxy-2-isopropylbutyric acid, the unique necic acid of PAs of the lycopsamine type [3].


  1. Semisynthetic pyrrolizidine alkaloid N-oxide antitumor agents. Esters of heliotridine. Zalkow, L.H., Glinski, J.A., Gelbaum, L.T., Moore, D., Melder, D., Powis, G. J. Med. Chem. (1988) [Pubmed]
  2. Microsomal formation of a pyrrolic alcohol glutathione conjugate of the pyrrolizidine alkaloid senecionine. Reed, R.L., Miranda, C.L., Kedzierski, B., Henderson, M.C., Buhler, D.R. Xenobiotica (1992) [Pubmed]
  3. Tissue distribution, core biosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species. Frölich, C., Ober, D., Hartmann, T. Phytochemistry (2007) [Pubmed]
WikiGenes - Universities