Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

HMDB06726 [(3S,8S,9S,10R,13R,14S,17R)- 10,13-dimethyl...

Synonyms: LMST01020014, AC1O57GJ, cholest-5-en-3beta-yl, CE(20:4(5Z,8Z,11Z,14Z), 20:4 Cholesterol ester, ...

Yin, H. et al., Noël, S.P. et al., Marchant, C.E. et al., Stylianopoulou, F. et al., Smaby, J.M. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on AIDS187900

A novel class of peroxides (termed dioxolane-isoprostanes) having a bicyclic endoperoxide moiety characteristic of the isoprostanes and a dioxolane peroxide functionality in the same molecule was identified in the product mixture formed from in vitro autoxidation of cholesteryl arachidonate [1].
Novel surface phase containing cholesteryl esters. 2. Nonequivalence of cholesteryl arachidonate and those with 18-carbon, cis-unsaturated acyl groups [2].
Among the individual cholesterol esters, cholesteryl arachidonate (C20:4) is preferentially utilized after ACTH treatment in all groups except the C57 males [3].
Most steryl esters had no effect on enzyme activity, but cholesteryl arachidonate (CA) was a potent inhibitor of parasite PLA2 [4].
The rate of hydrolysis of cholesteryl arachidonate differed markedly among the CEH [5].

Biological context of AIDS187900

Ceroid accumulation was greater for artificial lipoprotein composed of BSA complexed with cholesteryl arachidonate, than with cholesteryl linoleate. alpha-Tocopherol inhibited the ceroid accumulation, which was also dependent upon cell density [6].

Gene context of AIDS187900

This phenomenon may be crucial whenever total cholesterol has to be determined enzymatically in the serum of species that contain large amount of cholesteryl arachidonate such as rat, mouse, or dog serum [5].

References

Identification of a novel class of endoperoxides from arachidonate autoxidation. Yin, H., Morrow, J.D., Porter, N.A. J. Biol. Chem. (2004) [Pubmed]
Novel surface phase containing cholesteryl esters. 2. Nonequivalence of cholesteryl arachidonate and those with 18-carbon, cis-unsaturated acyl groups. Smaby, J.M., Brockman, H.L. Biochemistry (1981) [Pubmed]
Strain-dependent gonadal effects upon the response of adrenal cholesterol esters to ACTH in C57BL/10J and DBA/2J mice. Stylianopoulou, F., Clayton, R.B. Endocrinology (1976) [Pubmed]
Sterol and steryl ester regulation of phospholipase A2 from the mosquito parasite Lagenidium giganteum. Kerwin, J.L., MacKichan, J.K., Semon, M.J., Wiens, A.M., DeRose, C.C., Torvik, J.J. Lipids (1996) [Pubmed]
The activity of cholesterol ester hydrolase in the enzymatic determination of cholesterol: comparison of five enzymes obtained commercially. Noël, S.P., Dupras, R., Filion, A.M. Anal. Biochem. (1983) [Pubmed]
Lipid oxidation, lipoprotein cell-association and ceroid accumulation in P388D1 macrophage-like cells. Marchant, C.E., Bottoms, M.A., Law, N., Mitchinson, M.J., Hunt, J.V. Biochim. Biophys. Acta (1994) [Pubmed]

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