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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Novel surface phase containing cholesteryl esters. 2. Nonequivalence of cholesteryl arachidonate and those with 18-carbon, cis-unsaturated acyl groups.

Surface pressure--area isotherms for binary mixtures of cholesteryl octanoate, elaidate, stearate, oleate, linoleate, linolenate, and arachiodonate in mixtures with dioleoyllecithin, triolein, oleic acid, and oleoyl alcohol were measured at 24 degrees C. Analysis of the pressure and area characteristics as a function of composition showed that double-layer surface phase formation is primarily dependent on the structure of the acyl moiety of the cholesteryl ester. Cholesteryl esters with saturated or trans-unsaturated acyl chains apparently do not form double-layer surface phases. The esters of oleate, linoleate, and linolenate formed double-layer as well as monolayer phases and their properties in these phases were similar. In contrast to other cis-unsaturated esters, cholesteryl arachidonate formed a mixed monolayer phase with miscibility in all proportions and did not form a double-layer phase. Our results show that the polar lipid monolayer separating bulk cholesteryl ester from the aqueous milieu not only solubilizes finite amounts of cholesteryl esters but also can contribute to the organization of lipid adjacent to the monolayer. That such organization is observed with the predominant cholesteryl ester species of blood and aorta suggests a role for double-layer structure in regulating the transport and metabolism of cholesteryl esters in lipoproteins, arterial lipid deposits, and adrenal cortex. The absence of double-layer formation and high monolayer solubility of cholesteryl arachidonate suggest that it should be more abundant than other cholesteryl esters in bilayers and in monolayers surrounding bulk lipid phases.[1]


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