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Chemical Compound Review

SureCN1999862     1,4-dioxane-2,5-dione; oxepan-2-one

Synonyms: AC1L238S, D05540, 41706-81-4, Poliglecaprone 25, Poliglecaprone 90, ...
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Disease relevance of Poliglecaprone 25

  • Around the poliglecaprone 25, a diffused infiltration of a few mononuclear cells and fibrosis was recorded and formation of craters was observed on its surface [1].

High impact information on Poliglecaprone 25

  • This paper aimed to study rat subcutaneous tissue reaction to irradiated polyglactin 910, polydioxanone, poliglecaprone 25 and chromic gut and its correlation with the ultra-structural alterations the materials undergo [1].
  • The purpose of this study was to compare postoperative wound healing in canine ovariohysterectomy following the use of an absorbable monofilament poliglecaprone 25 suture in 2 different skin closure techniques, the buried continuous subcuticular (BCS) suture pattern and the simple interrupted (SI) suture pattern [2].

Analytical, diagnostic and therapeutic context of Poliglecaprone 25

  • CONCLUSION: Poliglecaprone 25 is a strong synthetic, absorbable, monofilament suture with low tissue reactivity that can be used in hair transplantation to close the donor wound with a single, running cutaneous stitch [3].
  • Segments of fresh porcine skin measuring 3.5 x 10 cm were approximated by one of four methods: 1) 2-octyl cyanoacrylate glue, 2) surgical staples, 3) 0.5 inch Steri-Strips, and 4) interrupted 4-0 poliglecaprone 25 sutures in a subcuticular fashion [4].
  • OBJECTIVE: To use poliglecaprone 25 for all ligations and closure in routine feline ovariohysterectomies and evaluate maintenance of tissue approximation and tissue reaction to the suture [5].


  1. Tissue reaction and surface morphology of absorbable sutures after in vivo exposure. Andrade, M.G., Weissman, R., Reis, S.R. Journal of materials science. Materials in medicine. (2006) [Pubmed]
  2. A comparison of 2 different suture patterns for skin closure of canine ovariohysterectomy. Sylvestre, A., Wilson, J., Hare, J. Can. Vet. J. (2002) [Pubmed]
  3. A new suture for hair transplantation: poliglecaprone 25. Bernstein, R.M., Rassman, W.R., Rashid, N. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2001) [Pubmed]
  4. Tensile strength of wound closure with cyanoacrylate glue. Shapiro, A.J., Dinsmore, R.C., North, J.H. The American surgeon. (2001) [Pubmed]
  5. Tissue reactivity to poliglecaprone 25 in the feline linea alba. Runk, A., Allen, S.W., Mahaffey, E.A. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (1999) [Pubmed]
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