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Chemical Compound Review

Poly(lactide-Co-glycoside)     2-hydroxyethanoic acid; 2-hydroxypropanoic...

Synonyms: Resolut LT, Resolut ST, Alzamer Depot, P2066_ALDRICH, Resomer RG 502, ...
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Disease relevance of Glycolic-lactic acid polyester

  • Fibrosis was also detected around the nylon and polypropylene sutures at 80 days, but not at all around the polydioxanone and polyglactin-910 sutures [1].
  • OBJECTIVE: Our aim was to evaluate the efficacy of polyglactin 910 mesh in preventing recurrent cystoceles and rectoceles [2].
  • Because there is no need for the suture to remain longer than until healing has occurred and as remaining foreign material will predispose to foreign body reactions and infection, it was considered important to test new absorbable materials like polyglactin 910 (Vicryl) and polyglycolic acid (Dexon) for closure of the dura mater [3].
  • STUDY DESIGN: One hundred fourteen women with anterior vaginal prolapse were randomly assigned to undergo anterior repair by one of 3 techniques: standard, standard plus polyglactin 910 mesh, or ultralateral anterior colporrhaphy [4].
  • In ureters sutured with polyglactin 910 cystic diverticula were observed eight months postoperatively [5].

Psychiatry related information on Glycolic-lactic acid polyester

  • Women allocated polyglactin 910 were less likely to have dyspareunia (8% versus 13%; RR 0.59, 95% CI 0.39 to 0.91; 2P = 0.02) and less likely to fail to resume pain-free intercourse (8% versus 14%; RR 0.57, 95% CI 0.38 to 0.87; 2P < 0.01) [6].

High impact information on Glycolic-lactic acid polyester


Chemical compound and disease context of Glycolic-lactic acid polyester


Biological context of Glycolic-lactic acid polyester


Anatomical context of Glycolic-lactic acid polyester


Associations of Glycolic-lactic acid polyester with other chemical compounds

  • The relationship between five different suture materials (expanded polytetrafluoroethylene (PTFE), polypropylene, polyglycolic acid, polydioxanone and polyglactin 910) and infection has been studied in 540 guinea-pig wounds contaminated with synergistic enteric organisms [24].
  • A 4 by 4 cm full-thickness resection of abdominal wall was closed with patches of polypropylene mesh (Marlex), polyglactin 910 mesh (Vicryl), expanded polytetrafluoroethylene (Gore-tex), Dacron-reinforced silicone rubber (Silastic), preserved human dura (PHD), or polypropylene mesh overlying gelatin film (Marlex and Gelfilm, respectively) [25].
  • Complications that were suture-related (obstruction or leak from the anastomotic site) occurred in 1 of 21 transplantations in the polyglyconate group compared with 8 of 26 in the polyglactin 910 group (p = 0.02) [26].
  • Study of the efficacy of Coated VICRYL Plus Antibacterial suture (coated Polyglactin 910 suture with Triclosan) in two animal models of general surgery [27].
  • Rectangular-shaped strips were cut from 3 periodontal membranes (expanded polytetrafluoroethylene, polyglactin 910, and polylactic acid) and glued to the buccal aspect of removable acrylic devices, which were applied to the molar-premolar region of the upper quadrants in 8 dental students [28].

Gene context of Glycolic-lactic acid polyester


Analytical, diagnostic and therapeutic context of Glycolic-lactic acid polyester

  • METHODS: 1542 women who had a spontaneous vaginal delivery with a second-degree perineal tear or episiotomy were randomly allocated to either the continuous (n=771) or interrupted (771) suturing method, and to either the more rapidly absorbed polyglactin 910 suture material (772) or standard polyglactin 910 material (770) [7].
  • To determine whether these reactions resulted primarily from transanastomotic pannus ingrowth, prostheses (30 mm x 4 mm) were constructed of three 10-mm long segments with Dacron segments on both ends and a middle polyglactin 910 (PG910) segment [32].
  • Polyglactin 910/polydioxanone bicomponent totally resorbable vascular prostheses [20].
  • METHODS: Policies of repair with polyglactin 910 or chromic catgut were compared [33].
  • CONCLUSIONS: Drug entrapment and release parameters estimated by the equations indicate more efficient matrix packing between PLGA 7525 and Resomer RG 502H in polymer-blended microspheres [34].


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  2. Prospective randomized trial of polyglactin 910 mesh to prevent recurrence of cystoceles and rectoceles. Sand, P.K., Koduri, S., Lobel, R.W., Winkler, H.A., Tomezsko, J., Culligan, P.J., Goldberg, R. Am. J. Obstet. Gynecol. (2001) [Pubmed]
  3. Absorbable or nonabsorbable suture materials for closure of the dura mater? Vällfors, B., Hansson, H.A., Svensson, J. Neurosurgery (1981) [Pubmed]
  4. Anterior colporrhaphy: a randomized trial of three surgical techniques. Weber, A.M., Walters, M.D., Piedmonte, M.R., Ballard, L.A. Am. J. Obstet. Gynecol. (2001) [Pubmed]
  5. Polyglactin 910 suture in urinary tract. Bartone, F.F., Gardner, P.J., Hutson, J.C. Urology (1977) [Pubmed]
  6. The Ipswich childbirth study: one year follow up of alternative methods used in perineal repair. Grant, A., Gordon, B., Mackrodat, C., Fern, E., Truesdale, A., Ayers, S. BJOG : an international journal of obstetrics and gynaecology. (2001) [Pubmed]
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  8. Grafting of cultured uroepithelium and bladder mucosa into de-epithelialized segments of colon in rabbits. Merguerian, P., Chavez, D.R., Hakim, S. J. Urol. (1994) [Pubmed]
  9. The effects of an atherogenic diet on macrophage/biomaterial interactions. Greisler, H.P., Ellinger, J., Henderson, S.C., Shaheen, A.M., Burgess, W.H., Kim, D.U., Lam, T.M. J. Vasc. Surg. (1991) [Pubmed]
  10. Conservative treatment of renal allograft rupture with polyglactin 910 mesh and gelatin resorcin formaldehyde glue. Chopin, D.K., Abbou, C.C., Lottmann, H.B., Popov, Z., Lang, P.R., Buisson, C.L., Belghiti, D., Colombel, M., Auvert, J.M. J. Urol. (1989) [Pubmed]
  11. A randomized clinical trial comparing two methods of fascia closure following midline laparotomy. Trimbos, J.B., Smit, I.B., Holm, J.P., Hermans, J. Archives of surgery (Chicago, Ill. : 1960) (1992) [Pubmed]
  12. Use of Vicryl (polyglactin-910) mesh implant for repair of orbital floor fracture causing diplopia: a study of 28 patients over 5 years. Mauriello, J.A., Wasserman, B., Kraut, R. Ophthalmic plastic and reconstructive surgery. (1993) [Pubmed]
  13. In vitro antimicrobial evaluation of Coated VICRYL* Plus Antibacterial Suture (coated polyglactin 910 with triclosan) using zone of inhibition assays. Rothenburger, S., Spangler, D., Bhende, S., Burkley, D. Surgical infections. (2002) [Pubmed]
  14. A new aneurysm wrapping material: polyglactin 910 + fibrin sealant. Uzan, M., Hanci, M., Kuday, C., Akar, Z., Shamsi, A.A., Ozlen, F., Oz, B., Deniz, E. Neurosurgical review. (1996) [Pubmed]
  15. Kinetics of cell proliferation as a function of vascular graft material. Greisler, H.P., Petsikas, D., Lam, T.M., Patel, N., Ellinger, J., Cabusao, E., Tattersall, C.W., Kim, D.U. J. Biomed. Mater. Res. (1993) [Pubmed]
  16. Unbiased stereological methods used for the quantitative evaluation of guided bone regeneration. Aaboe, M., Pinholt, E.M., Schou, S., Hjørting-Hansen, E. Clinical oral implants research. (1998) [Pubmed]
  17. Bone formation with discs or particles of natural coral skeleton plus polyglactin 910 mesh: histologic evaluation in rat calvaria. Naaman, N.B., Ouhayoun, J.P. The International journal of oral & maxillofacial implants. (1998) [Pubmed]
  18. Impact of chromic catgut versus polyglactin 910 versus fast-absorbing polyglactin 910 sutures for perineal repair: a randomized, controlled trial. Leroux, N., Bujold, E. Am. J. Obstet. Gynecol. (2006) [Pubmed]
  19. Histology and fertility effects of polydioxanone on rat reproductive tissue. Scoccia, B., Fortress, K., Marcovici, I., Benson, J.T. Eur. J. Obstet. Gynecol. Reprod. Biol. (1992) [Pubmed]
  20. Polyglactin 910/polydioxanone bicomponent totally resorbable vascular prostheses. Greisler, H.P., Endean, E.D., Klosak, J.J., Ellinger, J., Dennis, J.W., Buttle, K., Kim, D.U. J. Vasc. Surg. (1988) [Pubmed]
  21. Physicochemical, mechanical, and biological properties of commercial membranes for GTR. Milella, E., Ramires, P.A., Brescia, E., La Sala, G., Di Paola, L., Bruno, V. J. Biomed. Mater. Res. (2001) [Pubmed]
  22. The use of a biodegradable mesh to prevent radiation-associated small-bowel injury. Dasmahapatra, K.S., Swaminathan, A.P. Archives of surgery (Chicago, Ill. : 1960) (1991) [Pubmed]
  23. Vicryl mesh in pelvic floor reconstruction. Buchsbaum, H.J., Christopherson, W., Lifshitz, S., Bernstein, S. Archives of surgery (Chicago, Ill. : 1960) (1985) [Pubmed]
  24. Suture materials in contaminated wounds: a detailed comparison of a new suture with those currently in use. Paterson-Brown, S., Cheslyn-Curtis, S., Biglin, J., Dye, J., Easmon, C.S., Dudley, H.A. The British journal of surgery. (1987) [Pubmed]
  25. A comparison of prosthetic materials used to repair abdominal wall defects. Jenkins, S.D., Klamer, T.W., Parteka, J.J., Condon, R.E. Surgery (1983) [Pubmed]
  26. Biliary tract complications in orthotopic adult liver transplantation. Wilson, B.J., Marsh, J.W., Makowka, L., Stieber, A.C., Koneru, B., Todo, S., Tzakis, A., Gordon, R.D., Starzl, T.E. Am. J. Surg. (1989) [Pubmed]
  27. Study of the efficacy of Coated VICRYL Plus Antibacterial suture (coated Polyglactin 910 suture with Triclosan) in two animal models of general surgery. G??mez-Alonso, A., Garc??a-Criado, F.J., Parre??o-Manchado, F.C., Garc??a-S??nchez, J.E., Garc??a-S??nchez, E., Parre??o-Manchado, A., Zambrano-Cuadrado, Y. J. Infect. (2007) [Pubmed]
  28. Early bacterial accumulation on guided tissue regeneration membrane materials. An in vivo study. Zucchelli, G., Cesari, C., Clauser, C., DeSanctis, M. J. Periodontol. (1998) [Pubmed]
  29. Experimental study of the effect of different meshes on bacterial translocation. Baykal, A., Bagci, M., Aran, O., Hascelik, G., Korkmaz, A., Sayek, I. World journal of surgery. (1999) [Pubmed]
  30. Skin closure in carpal tunnel surgery: a prospective comparative study between nylon, polyglactin 910 and stainless steel sutures. Menovsky, T., Bartels, R.H., van Lindert, E.L., Grotenhuis, J.A. Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand. (2004) [Pubmed]
  31. Effect of bipolar cautery on tensile strength of 6-0 polyglactin 910 suture. Eustis, H.S., Marshburn, J.S. Journal of pediatric ophthalmology and strabismus. (2000) [Pubmed]
  32. Derivation of neointima in vascular grafts. Greisler, H.P., Dennis, J.W., Endean, E.D., Ellinger, J., Buttle, K.F., Kim, D.U. Circulation (1988) [Pubmed]
  33. The Ipswich Childbirth Study: 2. A randomised comparison of polyglactin 910 with chromic catgut for postpartum perineal repair. Mackrodt, C., Gordon, B., Fern, E., Ayers, S., Truesdale, A., Grant, A. British journal of obstetrics and gynaecology. (1998) [Pubmed]
  34. Effect of polymer blending on the release of ganciclovir from PLGA microspheres. Duvvuri, S., Gaurav Janoria, K., Mitra, A.K. Pharm. Res. (2006) [Pubmed]
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