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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Wound Healing

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Disease relevance of Wound Healing


Psychiatry related information on Wound Healing


High impact information on Wound Healing

  • Supplying PEPI corrects the wound-healing defect in SLPI null mice [8].
  • We describe a new contiguous-gene syndrome, involving the CYP21B and TNX genes, that results in 21-hydroxylase deficiency and a connective-tissue disorder consisting of skin and joint hyperextensibility, vascular fragility and poor wound healing [9].
  • These observations establish the requirement of gelsolin for rapid motile responses in cell types involved in stress responses such as hemostasis, inflammation, and wound healing [10].
  • Fibronectin (Fn) matrices are vital to vertebrate development and wound healing and modulate tumorigenesis [11].
  • Although TGF alpha deficiency affected skin and eyes, wound healing in these tissues was not impaired [12].

Chemical compound and disease context of Wound Healing


Biological context of Wound Healing


Anatomical context of Wound Healing


Associations of Wound Healing with chemical compounds


Gene context of Wound Healing


Analytical, diagnostic and therapeutic context of Wound Healing


  1. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Carmeliet, P., Moons, L., Luttun, A., Vincenti, V., Compernolle, V., De Mol, M., Wu, Y., Bono, F., Devy, L., Beck, H., Scholz, D., Acker, T., DiPalma, T., Dewerchin, M., Noel, A., Stalmans, I., Barra, A., Blacher, S., Vandendriessche, T., Ponten, A., Eriksson, U., Plate, K.H., Foidart, J.M., Schaper, W., Charnock-Jones, D.S., Hicklin, D.J., Herbert, J.M., Collen, D., Persico, M.G. Nat. Med. (2001) [Pubmed]
  2. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Millauer, B., Shawver, L.K., Plate, K.H., Risau, W., Ullrich, A. Nature (1994) [Pubmed]
  3. Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor. Schultz, G.S., White, M., Mitchell, R., Brown, G., Lynch, J., Twardzik, D.R., Todaro, G.J. Science (1987) [Pubmed]
  4. Vitronectin and its receptors. Felding-Habermann, B., Cheresh, D.A. Curr. Opin. Cell Biol. (1993) [Pubmed]
  5. Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors. Montesinos, M.C., Gadangi, P., Longaker, M., Sung, J., Levine, J., Nilsen, D., Reibman, J., Li, M., Jiang, C.K., Hirschhorn, R., Recht, P.A., Ostad, E., Levin, R.I., Cronstein, B.N. J. Exp. Med. (1997) [Pubmed]
  6. Social facilitation of wound healing. Detillion, C.E., Craft, T.K., Glasper, E.R., Prendergast, B.J., DeVries, A.C. Psychoneuroendocrinology (2004) [Pubmed]
  7. Trichloroacetic acid chemexfoliation (chemical peel) for extensive premalignant actinic damage of the face and scalp. Brodland, D.G., Roenigk, R.K. Mayo Clin. Proc. (1988) [Pubmed]
  8. Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Zhu, J., Nathan, C., Jin, W., Sim, D., Ashcroft, G.S., Wahl, S.M., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Wright, C.D., Ding, A. Cell (2002) [Pubmed]
  9. Tenascin-X deficiency is associated with Ehlers-Danlos syndrome. Burch, G.H., Gong, Y., Liu, W., Dettman, R.W., Curry, C.J., Smith, L., Miller, W.L., Bristow, J. Nat. Genet. (1997) [Pubmed]
  10. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Witke, W., Sharpe, A.H., Hartwig, J.H., Azuma, T., Stossel, T.P., Kwiatkowski, D.J. Cell (1995) [Pubmed]
  11. Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Wu, C., Keivens, V.M., O'Toole, T.E., McDonald, J.A., Ginsberg, M.H. Cell (1995) [Pubmed]
  12. TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Luetteke, N.C., Qiu, T.H., Peiffer, R.L., Oliver, P., Smithies, O., Lee, D.C. Cell (1993) [Pubmed]
  13. Cloning and expression of heparinase I gene from Flavobacterium heparinum. Sasisekharan, R., Bulmer, M., Moremen, K.W., Cooney, C.L., Langer, R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  14. Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets. Yatomi, Y., Ruan, F., Hakomori, S., Igarashi, Y. Blood (1995) [Pubmed]
  15. Long-term ethanol consumption alters the hepatic response to the regenerative effects of tumor necrosis factor-alpha. Akerman, P.A., Cote, P.M., Yang, S.Q., McClain, C., Nelson, S., Bagby, G., Diehl, A.M. Hepatology (1993) [Pubmed]
  16. SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. Coluccia, A.M., Benati, D., Dekhil, H., De Filippo, A., Lan, C., Gambacorti-Passerini, C. Cancer Res. (2006) [Pubmed]
  17. Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing. Paavonen, K., Ekman, N., Wirzenius, M., Rajantie, I., Poutanen, M., Alitalo, K. Mol. Biol. Cell (2004) [Pubmed]
  18. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Kim, K.J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H.S., Ferrara, N. Nature (1993) [Pubmed]
  19. Localized production of TGF-beta mRNA in tumour promoter-stimulated mouse epidermis. Akhurst, R.J., Fee, F., Balmain, A. Nature (1988) [Pubmed]
  20. Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor. Lee, P.L., Johnson, D.E., Cousens, L.S., Fried, V.A., Williams, L.T. Science (1989) [Pubmed]
  21. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Cao, L., Li, W., Kim, S., Brodie, S.G., Deng, C.X. Genes Dev. (2003) [Pubmed]
  22. NF-kappa B-like factors mediate interleukin 1 induction of c-myc gene transcription in fibroblasts. Kessler, D.J., Duyao, M.P., Spicer, D.B., Sonenshein, G.E. J. Exp. Med. (1992) [Pubmed]
  23. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Jones, M.K., Wang, H., Peskar, B.M., Levin, E., Itani, R.M., Sarfeh, I.J., Tarnawski, A.S. Nat. Med. (1999) [Pubmed]
  24. Kinase signaling cascades that modulate peroxisome proliferator-activated receptors. Gelman, L., Michalik, L., Desvergne, B., Wahli, W. Curr. Opin. Cell Biol. (2005) [Pubmed]
  25. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. Brown, L.F., Yeo, K.T., Berse, B., Yeo, T.K., Senger, D.R., Dvorak, H.F., van de Water, L. J. Exp. Med. (1992) [Pubmed]
  26. Interaction between the insulin-like growth factor family and the integrin receptor family in tissue repair processes. Evidence in a rabbit ear dermal ulcer model. Galiano, R.D., Zhao, L.L., Clemmons, D.R., Roth, S.I., Lin, X., Mustoe, T.A. J. Clin. Invest. (1996) [Pubmed]
  27. Expression of integrins and basement membrane components by wound keratinocytes. Larjava, H., Salo, T., Haapasalmi, K., Kramer, R.H., Heino, J. J. Clin. Invest. (1993) [Pubmed]
  28. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Ashcroft, G.S., Dodsworth, J., van Boxtel, E., Tarnuzzer, R.W., Horan, M.A., Schultz, G.S., Ferguson, M.W. Nat. Med. (1997) [Pubmed]
  29. Leukocyte, rather than tumor-produced SPARC, determines stroma and collagen type IV deposition in mammary carcinoma. Sangaletti, S., Stoppacciaro, A., Guiducci, C., Torrisi, M.R., Colombo, M.P. J. Exp. Med. (2003) [Pubmed]
  30. Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. Gronert, K., Gewirtz, A., Madara, J.L., Serhan, C.N. J. Exp. Med. (1998) [Pubmed]
  31. Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis. Hertle, M.D., Kubler, M.D., Leigh, I.M., Watt, F.M. J. Clin. Invest. (1992) [Pubmed]
  32. Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Reynolds, L.E., Conti, F.J., Lucas, M., Grose, R., Robinson, S., Stone, M., Saunders, G., Dickson, C., Hynes, R.O., Lacy-Hulbert, A., Hodivala-Dilke, K. Nat. Med. (2005) [Pubmed]
  33. Keratinocyte growth factor is required for hair development but not for wound healing. Guo, L., Degenstein, L., Fuchs, E. Genes Dev. (1996) [Pubmed]
  34. Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture. Stoll, S., Garner, W., Elder, J. J. Clin. Invest. (1997) [Pubmed]
  35. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Ashcroft, G.S., Yang, X., Glick, A.B., Weinstein, M., Letterio, J.L., Mizel, D.E., Anzano, M., Greenwell-Wild, T., Wahl, S.M., Deng, C., Roberts, A.B. Nat. Cell Biol. (1999) [Pubmed]
  36. Distinct localization of collagenase and tissue inhibitor of metalloproteinases expression in wound healing associated with ulcerative pyogenic granuloma. Saarialho-Kere, U.K., Chang, E.S., Welgus, H.G., Parks, W.C. J. Clin. Invest. (1992) [Pubmed]
  37. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. Bataller, R., Schwabe, R.F., Choi, Y.H., Yang, L., Paik, Y.H., Lindquist, J., Qian, T., Schoonhoven, R., Hagedorn, C.H., Lemasters, J.J., Brenner, D.A. J. Clin. Invest. (2003) [Pubmed]
  38. Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1alpha variant for local induction of angiogenesis. Trentin, D., Hall, H., Wechsler, S., Hubbell, J.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  39. Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice. Carmeliet, P., Moons, L., Lijnen, R., Janssens, S., Lupu, F., Collen, D., Gerard, R.D. Circulation (1997) [Pubmed]
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