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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Subcutaneous Tissue

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Disease relevance of Subcutaneous Tissue


High impact information on Subcutaneous Tissue

  • By contrast, lin-12 mediates somatic cell interactions, including those between the precursor cells that form the vulval hypodermis (VPCs) [6].
  • Subsequent systemic treatment with a dexamethasone (0.08 mg/day) insulin mixture injected subcutaneously into the depressed areas resulted in an impressive return of subcutaneous tissue after eight months of continuous therapy [7].
  • Lactate release from the subcutaneous tissue in lean and obese men [8].
  • The extracellular pH and temperature of Walker 256 carcinoma and of normal subcutaneous tissue were measured continuously in unanesthetized female Sprague-Dawley rats for up to 20 hours following glucose or galactose administration [9].
  • Mutations in mua-3 cause a separation of the hypodermis from the cuticle, suggesting this gene is required for maintaining hypodermal-cuticle attachment as the animal grows in size postembryonically. mua-3 encodes a predicted 3,767 amino acid protein with a large extracellular domain, a single transmembrane helix, and a smaller cytoplasmic domain [10].

Chemical compound and disease context of Subcutaneous Tissue


Biological context of Subcutaneous Tissue


Anatomical context of Subcutaneous Tissue


Associations of Subcutaneous Tissue with chemical compounds


Gene context of Subcutaneous Tissue

  • Elimination of nob-1 and php-3 functions causes gross embryonic defects in both posterior patterning and morphogenetic movements of the posterior hypodermis, as well as posterior-to-anterior cell fate transformations and lethality [31].
  • Furthermore, constitutive expression of daf-9 in the hypodermis suppresses dauer arrest of daf-7 mutant animals and inhibits dauer remodelling of some tissues in daf-2 mutant animals [17].
  • As dbl-1 is expressed primarily in the nervous system, these results suggest a model in which postembryonic growth of hypodermal cells is regulated by TGFbeta-related signaling from the nervous system to the hypodermis [32].
  • The time of LIN-29 appearance in the hypodermis is controlled by the heterochronic gene pathway: LIN-29 accumulates in the hypodermis abnormally early, during the third larval stage, in loss-of-function lin-14, lin-28 and lin-42 mutants, and fails to accumulate in hypodermis of lin-4 mutants [33].
  • Employing a double-immunocytochemical technique, this study investigated in Wistar rats with Freund's complete adjuvant-induced hind paw inflammation whether immune cells within blood and inflamed subcutaneous tissue express CRH R1 and/or CRH R2 together with the opioid peptide beta-endorphin (END) [34].

Analytical, diagnostic and therapeutic context of Subcutaneous Tissue


  1. Mutations in PHF6 are associated with Börjeson-Forssman-Lehmann syndrome. Lower, K.M., Turner, G., Kerr, B.A., Mathews, K.D., Shaw, M.A., Gedeon, A.K., Schelley, S., Hoyme, H.E., White, S.M., Delatycki, M.B., Lampe, A.K., Clayton-Smith, J., Stewart, H., van Ravenswaay, C.M., de Vries, B.B., Cox, B., Grompe, M., Ross, S., Thomas, P., Mulley, J.C., Gécz, J. Nat. Genet. (2002) [Pubmed]
  2. Immunoglobulin D myeloma and amyloidosis: immunochemical and structural studies of Bence Jones and amyloid fibrillar proteins. White, G.C., Jacobson, R.J., Binder, R.A., Linke, R.P., Glenner, G.G. Blood (1975) [Pubmed]
  3. Progressive facial hemiatrophy and epilepsy: a common underlying dysgenetic mechanism. Dupont, S., Catala, M., Hasboun, D., Semah, F., Baulac, M. Neurology (1997) [Pubmed]
  4. Pharmacokinetics of enrofloxacin and danofloxacin in plasma, inflammatory exudate, and bronchial secretions of calves following subcutaneous administration. McKellar, Q., Gibson, I., Monteiro, A., Bregante, M. Antimicrob. Agents Chemother. (1999) [Pubmed]
  5. Cutaneous Thorotrast granulomas and chronic lymphocytic leukemia following Thorotrast angiography. Wargotz, E.S. Am. J. Surg. Pathol. (1985) [Pubmed]
  6. Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans. Mango, S.E., Maine, E.M., Kimble, J. Nature (1991) [Pubmed]
  7. Amelioration of insulin lipoatrophy by dexamethasone injection. Whitley, T.H., Lawrence, P.A., Smith, C.L. JAMA (1976) [Pubmed]
  8. Lactate release from the subcutaneous tissue in lean and obese men. Jansson, P.A., Larsson, A., Smith, U., Lönnroth, P. J. Clin. Invest. (1994) [Pubmed]
  9. Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia. Jain, R.K., Shah, S.A., Finney, P.L. J. Natl. Cancer Inst. (1984) [Pubmed]
  10. mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of epithelial attachment complexes. Bercher, M., Wahl, J., Vogel, B.E., Lu, C., Hedgecock, E.M., Hall, D.H., Plenefisch, J.D. J. Cell Biol. (2001) [Pubmed]
  11. Demonstration of protein AA in subcutaneous fat tissue obtained by fine needle biopsy. Westermark, P., Stenkvist, B., Natvig, J.B., Olding-Stenkvist, E. Ann. Rheum. Dis. (1979) [Pubmed]
  12. Interstitial quinacrine for elimination of abnormal tissue; therapy of experimental glioma. Sotelo, J., Guevara, P., Reyes, S., Arrieta, O. Surgery (2000) [Pubmed]
  13. Inhibition of growth of human breast carcinomas in vivo by somatostatin analog SMS 201-995: treatment of nude mouse xenografts. Weber, C., Merriam, L., Koschitzky, T., Karp, F., Benson, M., Forde, K., LoGerfo, P. Surgery (1989) [Pubmed]
  14. Adenosine triphosphate-magnesium chloride in radiation injury. Senagore, A.J., Milsom, J.W., Walshaw, R.K., Mostoskey, U., Dunstan, R., Chaudry, I.H. Surgery (1992) [Pubmed]
  15. Targeted gene therapy toward astrocytoma using a Cre/loxP-based adenovirus system. Maeda, M., Namikawa, K., Kobayashi, I., Ohba, N., Takahara, Y., Kadono, C., Tanaka, A., Kiyama, H. Brain Res. (2006) [Pubmed]
  16. MEC-8 regulates alternative splicing of unc-52 transcripts in C. elegans hypodermal cells. Spike, C.A., Davies, A.G., Shaw, J.E., Herman, R.K. Development (2002) [Pubmed]
  17. Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Mak, H.Y., Ruvkun, G. Development (2004) [Pubmed]
  18. Control of body size by SMA-5, a homolog of MAP kinase BMK1/ERK5, in C. elegans. Watanabe, N., Nagamatsu, Y., Gengyo-Ando, K., Mitani, S., Ohshima, Y. Development (2005) [Pubmed]
  19. The Pristionchus HOX gene Ppa-lin-39 inhibits programmed cell death to specify the vulva equivalence group and is not required during vulval induction. Sommer, R.J., Eizinger, A., Lee, K.Z., Jungblut, B., Bubeck, A., Schlak, I. Development (1998) [Pubmed]
  20. Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42. Tennessen, J.M., Gardner, H.F., Volk, M.L., Rougvie, A.E. Dev. Biol. (2006) [Pubmed]
  21. Transcutaneous oxygen tension in legs and feet of diabetic patients. Gaylarde, P.M., Fonseca, V.A., Llewellyn, G., Sarkany, I., Thomas, P.K., Dandona, P. Diabetes (1988) [Pubmed]
  22. CHE-14, a protein with a sterol-sensing domain, is required for apical sorting in C. elegans ectodermal epithelial cells. Michaux, G., Gansmuller, A., Hindelang, C., Labouesse, M. Curr. Biol. (2000) [Pubmed]
  23. Increased lactate release per fat cell in normoglycemic first-degree relatives of individuals with type 2 diabetes. Sandqvist, M.M., Eriksson, J.W., Jansson, P.A. Diabetes (2001) [Pubmed]
  24. Developmental regulation of apolipoprotein B mRNA editing is an autonomous function of small intestine involving homeobox gene Cdx1. Patterson, A.P., Chen, Z., Rubin, D.C., Moucadel, V., Iovanna, J.L., Brewer, H.B., Eggerman, T.L. J. Biol. Chem. (2003) [Pubmed]
  25. Use of ticarcillin disodium plus clavulanate potassium in the management of acute bacterial infections in children. Gooch, W.M., Swenson, E., Higbee, M.D. Am. J. Med. (1985) [Pubmed]
  26. Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues. Gerisch, B., Antebi, A. Development (2004) [Pubmed]
  27. Effects of insulin deprivation and replacement on in vivo subcutaneous adipose tissue substrate metabolism in humans. Hagström-Toft, E., Arner, P., Näslund, B., Ungerstedt, U., Bolinder, J. Diabetes (1991) [Pubmed]
  28. Clinical images: steroid-induced subcutaneous tissue atrophy. Ching, D.W., Dellow, P.M. Arthritis Rheum. (1997) [Pubmed]
  29. Penetration of cefmenoxime into serum, gynecologic tissues, and heart valves. Daschner, F.D., Petersen, E.E., Frank, U., Hornig, D. Am. J. Med. (1984) [Pubmed]
  30. Inhibition of pancreatic glucagon responses to arginine by human insulin (recombinant DNA) and purified porcine insulin in normal and diabetic subjects. Raptis, S., Hadjidakis, D., Enzmann, F., Raptis, A., Diamantopoulos, E., Rosenthal, J. Diabetes Care (1982) [Pubmed]
  31. Caenorhabditis elegans embryonic axial patterning requires two recently discovered posterior-group Hox genes. Van Auken, K., Weaver, D.C., Edgar, L.G., Wood, W.B. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  32. The expression of TGFbeta signal transducers in the hypodermis regulates body size in C. elegans. Wang, J., Tokarz, R., Savage-Dunn, C. Development (2002) [Pubmed]
  33. Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development. Bettinger, J.C., Lee, K., Rougvie, A.E. Development (1996) [Pubmed]
  34. Involvement of corticotropin-releasing hormone receptor subtypes 1 and 2 in peripheral opioid-mediated inhibition of inflammatory pain. Mousa, S.A., Bopaiah, C.P., Stein, C., Schäfer, M. Pain (2003) [Pubmed]
  35. On line continuous monitoring of subcutaneous tissue glucose in men by combining portable glucosensor with microdialysis. Meyerhoff, C., Bischof, F., Sternberg, F., Zier, H., Pfeiffer, E.F. Diabetologia (1992) [Pubmed]
  36. Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor. Pastrana, D.V., Raghavan, N., FitzGerald, P., Eisinger, S.W., Metz, C., Bucala, R., Schleimer, R.P., Bickel, C., Scott, A.L. Infect. Immun. (1998) [Pubmed]
  37. Penetration of metronidazole to tissues. Holter, O., Bergan, T., Flørenes, T., Leinebø, O. J. Antimicrob. Chemother. (1983) [Pubmed]
  38. A case of apocrine adenocarcinoma associated with hamartomatous apocrine gland hyperplasia of both axillae. Nishikawa, Y., Tokusashi, Y., Saito, Y., Ogawa, K., Miyokawa, N., Katagiri, M. Am. J. Surg. Pathol. (1994) [Pubmed]
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