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Chemical Compound Review:

AC1LCV0P 5-amino-1-[3,4-dihydroxy-5...

Synonyms:

This record was replaced with 1010.

Constantine, C.Z. et al., Groziak, M.P. et al., Meyer, E. et al., Thoden, J.B. et al.

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Disease relevance of phosphoribosyl-carboxy-aminoimidazole

FAIRs was synthesized directly from the sodium salt of 5-amino-1-(beta-D-ribofuranosyl)imidazole-4-carboxylic acid (CAIR) along a reaction sequence involving a tandem N-formylation/decarboxylation that may have a mechanistic connection to the Escherichia coli purE-catalyzed constitutional isomerization of N5-CAIR to CAIR [1].
Biochemical and structural studies of N5-carboxyaminoimidazole ribonucleotide mutase from the acidophilic bacterium Acetobacter aceti [2].

High impact information on phosphoribosyl-carboxy-aminoimidazole

The carboxylate moiety is positioned in a small pocket proposed to facilitate nucleotide decarboxylation in the forward direction (N5-CAIR --> CAIR) [Meyer, E., Kappock, T. J., Osuji, C., and Stubbe, J. (1999) Biochemistry 38, 3012-3018] [2].
Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase [3].
Escherichia coli PurK, a dimeric N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) synthetase, catalyzes the conversion of 5-aminoimidazole ribonucleotide (AIR), ATP, and bicarbonate to N5-CAIR, ADP, and Pi [4].

References

Effect of a chemical modification on the hydrated adenosine intermediate produced by adenosine deaminase and a model reaction for a potential mechanism of action of 5-aminoimidazole ribonucleotide carboxylase. Groziak, M.P., Huan, Z.W., Ding, H., Meng, Z., Stevens, W.C., Robinson, P.D. J. Med. Chem. (1997) [Pubmed]
Biochemical and structural studies of N5-carboxyaminoimidazole ribonucleotide mutase from the acidophilic bacterium Acetobacter aceti. Constantine, C.Z., Starks, C.M., Mill, C.P., Ransome, A.E., Karpowicz, S.J., Francois, J.A., Goodman, R.A., Kappock, T.J. Biochemistry (2006) [Pubmed]
Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase. Meyer, E., Kappock, T.J., Osuji, C., Stubbe, J. Biochemistry (1999) [Pubmed]
Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily. Thoden, J.B., Kappock, T.J., Stubbe, J., Holden, H.M. Biochemistry (1999) [Pubmed]

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