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Chemical Compound Review

HMDB01235     [(2R,3S,4R,5R)-5-(5- aminoimidazol-1-yl)-3...

Synonyms: AC1L4PJF, AC1Q6RVY, AR-1G6991, AR-1G6992, C03373, ...
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Disease relevance of Aminoimidazole ribonucleotide


High impact information on Aminoimidazole ribonucleotide


Chemical compound and disease context of Aminoimidazole ribonucleotide


Biological context of Aminoimidazole ribonucleotide


Associations of Aminoimidazole ribonucleotide with other chemical compounds


Gene context of Aminoimidazole ribonucleotide


  1. Cloning of a chicken liver cDNA encoding 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase by functional complementation of Escherichia coli pur mutants. Chen, Z.D., Dixon, J.E., Zalkin, H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  2. Mammalian glycinamide ribonucleotide transformylase. Kinetic mechanism and associated de novo purine biosynthetic activities. Caperelli, C.A. J. Biol. Chem. (1989) [Pubmed]
  3. Altered pathway routing in a class of Salmonella enterica serovar Typhimurium mutants defective in aminoimidazole ribonucleotide synthetase. Zilles, J.L., Kappock, T.J., Stubbe, J., Downs, D.M. J. Bacteriol. (2001) [Pubmed]
  4. Genomic organization of purK and purE in Brevibacterium ammoniagenes ATCC 6872: purE locus provides a clue for genomic evolution. Chung, S.O., Lee, J.H., Lee, S.Y., Lee, D.S. FEMS Microbiol. Lett. (1996) [Pubmed]
  5. Conversion of 5-aminoimidazole ribotide to the pyrimidine of thiamin in enterobacteria: study of the pathway with specifically labeled samples of riboside. Estramareix, B., David, S. Biochim. Biophys. Acta (1990) [Pubmed]
  6. Carbocyclic substrates for de novo purine biosynthesis. Liu, D.S., Caperelli, C.A. J. Biol. Chem. (1991) [Pubmed]
  7. Identification and nucleotide sequence of a gene encoding 5'-phosphoribosylglycinamide transformylase in Escherichia coli K12. Smith, J.M., Daum, H.A. J. Biol. Chem. (1987) [Pubmed]
  8. Nucleotide sequence of the purM gene encoding 5'-phosphoribosyl-5-aminoimidazole synthetase of Escherichia coli K12. Smith, J.M., Daum, H.A. J. Biol. Chem. (1986) [Pubmed]
  9. Isolating the Arabidopsis thaliana genes for de novo purine synthesis by suppression of Escherichia coli mutants. I. 5'-Phosphoribosyl-5-aminoimidazole synthetase. Senecoff, J.F., Meagher, R.B. Plant Physiol. (1993) [Pubmed]
  10. The Saccharomyces cerevisiae ADE5,7 protein is homologous to overlapping Drosophila melanogaster Gart polypeptides. Henikoff, S. J. Mol. Biol. (1986) [Pubmed]
  11. Evidence that rseC, a gene in the rpoE cluster, has a role in thiamine synthesis in Salmonella typhimurium. Beck, B.J., Connolly, L.E., De Las Peñas, A., Downs, D.M. J. Bacteriol. (1997) [Pubmed]
  12. Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. Firestine, S.M., Misialek, S., Toffaletti, D.L., Klem, T.J., Perfect, J.R., Davisson, V.J. Arch. Biochem. Biophys. (1998) [Pubmed]
  13. Investigation of the ATP binding site of Escherichia coli aminoimidazole ribonucleotide synthetase using affinity labeling and site-directed mutagenesis. Mueller, E.J., Oh, S., Kavalerchik, E., Kappock, T.J., Meyer, E., Li, C., Ealick, S.E., Stubbe, J. Biochemistry (1999) [Pubmed]
  14. Purification and characterization of aminoimidazole ribonucleotide synthetase from Escherichia coli. Schrimsher, J.L., Schendel, F.J., Stubbe, J., Smith, J.M. Biochemistry (1986) [Pubmed]
  15. Nucleotide sequence analysis of the purEK operon encoding 5'-phosphoribosyl-5-aminoimidazole carboxylase of Escherichia coli K-12. Tiedeman, A.A., Keyhani, J., Kamholz, J., Daum, H.A., Gots, J.S., Smith, J.M. J. Bacteriol. (1989) [Pubmed]
  16. Some physiological alteration associated with pleiotropic cross resistance and collateral sensitivity in Saccharomyces cerevisiae. Rank, G.H., Gerlach, J.H., Robertson, A.J. Mol. Gen. Genet. (1976) [Pubmed]
  17. Effect of a chemical modification on the hydrated adenosine intermediate produced by adenosine deaminase and a model reaction for a potential mechanism of action of 5-aminoimidazole ribonucleotide carboxylase. Groziak, M.P., Huan, Z.W., Ding, H., Meng, Z., Stevens, W.C., Robinson, P.D. J. Med. Chem. (1997) [Pubmed]
  18. Biosynthesis of thiamine: origin of the methyl carbon atom of the pyrimidine moiety in Salmonella typhimurium. Estramareix, B., David, S. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  19. A system for deletion and complementation of Candida glabrata genes amenable to high-throughput application. Willins, D.A., Shimer, G.H., Cottarel, G. Gene (2002) [Pubmed]
  20. Dual control of the gua operon of Escherichia coli K12 by adenine and guanine nucleotides. Mehra, R.K., Drabble, W.T. J. Gen. Microbiol. (1981) [Pubmed]
  21. A high-copy-number ADE2-bearing plasmid for transformation of Candida glabrata. Hanic-Joyce, P.J., Joyce, P.B. Gene (1998) [Pubmed]
  22. Sequence of the bifunctional ade1 gene in the purine biosynthetic pathway of the fission yeast Schizosaccharomyces pombe. McKenzie, R., Schuchert, P., Kilbey, B. Curr. Genet. (1987) [Pubmed]
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