Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

C13455 5-[(1S)-1-hydroxy-2,6,6- trimethyl-4-oxo-1...

Synonyms:

González-Guzmán, M. et al., Seo, M. et al., Seo, M. et al.

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Disease relevance of C13455

Recombinant ABA2 protein produced in Escherichia coli exhibits a K(m) value for xanthoxin of 19 micro M and catalyzes in a NAD-dependent manner the conversion of xanthoxin to abscisic aldehyde, as determined by HPLC-mass spectrometry [1].

High impact information on C13455

The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde [1].
We have reported the occurrence of three isoforms of aldehyde oxidase, AOalpha, AObeta and AOgamma, in Arabidopsis thaliana seedlings, but none oxidized abscisic aldehyde [2].

Associations of C13455 with other chemical compounds

Oxidation of abscisic aldehyde is the last step of ABA biosynthesis and is catalysed by aldehyde oxidase (EC 1.2.3.1) [2].

Gene context of C13455

The activity was about 5 times higher in the extract of the sur1 seedlings, indicating that AO1 also has a substrate preference for abscisic aldehyde [3].

References

The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde. González-Guzmán, M., Apostolova, N., Bellés, J.M., Barrero, J.M., Piqueras, P., Ponce, M.R., Micol, J.L., Serrano, R., Rodríguez, P.L. Plant Cell (2002) [Pubmed]
Abscisic aldehyde oxidase in leaves of Arabidopsis thaliana. Seo, M., Koiwai, H., Akaba, S., Komano, T., Oritani, T., Kamiya, Y., Koshiba, T. Plant J. (2000) [Pubmed]
Higher activity of an aldehyde oxidase in the auxin-overproducing superroot1 mutant of Arabidopsis thaliana. Seo, M., Akaba, S., Oritani, T., Delarue, M., Bellini, C., Caboche, M., Koshiba, T. Plant Physiol. (1998) [Pubmed]

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