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Chemical Compound Review

Argamine     (2S)-2-amino-5- (diaminomethylideneamino)pe...

Synonyms: R-Gene, L-ARGININE HCL, R-gene 10, H-Arg-OH.HCl, ARGININE, (L), ...
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Disease relevance of arginine

  • At 0, 1, 2, and 3 hr after each exercise bout, the subjects ingested either a carbohydrate (CHO) supplement (1 g carbohydrate/kg body weight) or a carbohydrate-arginine (CHO/AA) supplement (1 g carbohydrate/kg body mass and 0.08 g arginine-hydrochloride/kg body weight) [1].
  • Studies on therapy of metabolic alkalosis during experimental uremia. Influences of arginine-hydrochloride on the intra- and extracellular acid-base status of the rat [2].
 

High impact information on arginine

  • Distinctive gel shift bands are generated by rat nuclear extracts from mature testis, kidney, brain, spleen and liver, which bind to the cis-acting SRE (Serum response element) and Prot1C (Protamine 1 Consensus) oligonucleotide sequences [Queralt R. and Oliva R. Gene. 133 (1993) 197-204] [3].
  • L-arginine (CAS 1119-34-2), a NO precursor, displayed a triphasic pattern as antinociception-nociception-antinociception (61.8 +/- 7.8, -36.5 +/- 12.7 and 17.0 +/- 4.3%, 5, 40 and 50 mg/kg, s.c., respectively) [4].

References

  1. The effect of a carbohydrate--arginine supplement on postexercise carbohydrate metabolism. Yaspelkis, B.B., Ivy, J.L. International journal of sport nutrition. (1999) [Pubmed]
  2. Studies on therapy of metabolic alkalosis during experimental uremia. Influences of arginine-hydrochloride on the intra- and extracellular acid-base status of the rat. Rothe, K.F., Flüchter, S.H., Schorer, R. Urologia internationalis. (1986) [Pubmed]
  3. Demonstration of trans-acting factors binding to the promoter region of the testis-specific rat protamine P1 gene. Queralt, R., Oliva, R. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  4. The role of L-arginine/nitric oxide pathway in the antinociceptive activity of pyridoxine in mouse. Abacioğlu, N., Tunçtan, B., Cakici, I., Akbulut, E., Uludağ, O., Kanzik, I. Arzneimittel-Forschung. (2001) [Pubmed]
 
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