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Disease relevance of Uremia


Psychiatry related information on Uremia


High impact information on Uremia


Chemical compound and disease context of Uremia

  • We performed detailed studies of renal function in two of five related patients with normal serum creatinine levels to determine the mechanism of their chronic azotemia [12].
  • Familial azotemia. Impaired urea excretion despite normal renal function [12].
  • A selective decrease of hepatic triglyceride lipase with normal lipoprotein lipase was found in conservatively treated uremia and in patients undergoing hemodialysis [13].
  • Although the mechanism for the impairment of nitrogen use caused by High Nitrogen Vivonex is unknown, its low biologic value and tendency to cause azotemia should be kept in mind [14].
  • Biotin for neurologic disorders of uremia [15].

Biological context of Uremia


Anatomical context of Uremia


Gene context of Uremia

  • The data provide one possible pathway for the participation of excess PTH in the genesis of the anemia of uremia [26].
  • Corrected leptin levels were elevated. db/db mice and MC4-RKO mice resisted the cachexic effects of uremia on weight gain, body composition, and metabolic rate [17].
  • The ability of plasma from individual uremic patients to inhibit TPMT also correlated with its ability to inhibit two other drug metabolizing methyltransferases in the RBC, catechol-O-methyltransferase and phenol-O-methyltransferase, RBC TMT activity is not altered in patients with uremia [27].
  • Despite the reduction of hepatic IGF-I mRNA abundance, plasma IGF-I levels in uremia were not different from ad libitum-fed controls [28].
  • By Northern blot analysis, hepatic IGFBP-1 mRNA levels in uremia were 2-fold higher than in controls [28].

Analytical, diagnostic and therapeutic context of Uremia


  1. Effect of serum parathyroid hormone and bone marrow fibrosis on the response to erythropoietin in uremia. Rao, D.S., Shih, M.S., Mohini, R. N. Engl. J. Med. (1993) [Pubmed]
  2. Cimetidine doesn't help pruritus of uremia. Zappacosta, A.R., Hauss, D. N. Engl. J. Med. (1979) [Pubmed]
  3. Search for the uremic toxin. Decreased motor-nerve conduction velocity and elevated parathyroid hormone in uremia. Avram, M.M., Feinfeld, D.A., Huatuco, A.H. N. Engl. J. Med. (1978) [Pubmed]
  4. Risk factors for hypoglycemia associated with pentamidine therapy for Pneumocystis pneumonia. Waskin, H., Stehr-Green, J.K., Helmick, C.G., Sattler, F.R. JAMA (1988) [Pubmed]
  5. Phenformin and lactic acidosis. Conlay, L.A., Loewenstein, J.E. JAMA (1976) [Pubmed]
  6. A possible direct precursor of thyrotropin-releasing hormone, pGlu-His-Pro-Gly, stimulates prolactin secretion in anorexia nervosa. Mori, M., Murakami, M., Satoh, T., Miyashita, K., Iriuchijima, T., Yamada, M., Inukai, T., Kobayashi, I. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  7. Reversal of lesions of diabetic nephropathy after pancreas transplantation. Fioretto, P., Steffes, M.W., Sutherland, D.E., Goetz, F.C., Mauer, M. N. Engl. J. Med. (1998) [Pubmed]
  8. Losartan-induced azotemia in a diabetic recipient of a kidney transplant. Cohen, L.S., Friedman, E.A. N. Engl. J. Med. (1996) [Pubmed]
  9. A controlled trial of nimodipine in acute ischemic stroke. Gelmers, H.J., Gorter, K., de Weerdt, C.J., Wiezer, H.J. N. Engl. J. Med. (1988) [Pubmed]
  10. Aluminum intoxication from aluminum-containing phosphate binders in children with azotemia not undergoing dialysis. Andreoli, S.P., Bergstein, J.M., Sherrard, D.J. N. Engl. J. Med. (1984) [Pubmed]
  11. Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia. Mannucci, P.M., Remuzzi, G., Pusineri, F., Lombardi, R., Valsecchi, C., Mecca, G., Zimmerman, T.S. N. Engl. J. Med. (1983) [Pubmed]
  12. Familial azotemia. Impaired urea excretion despite normal renal function. Hsu, C.H., Kurtz, T.W., Massari, P.U., Ponze, S.A., Chang, B.S. N. Engl. J. Med. (1978) [Pubmed]
  13. Selective deficiency of hepatic triglyceride lipase in uremic patients. Mordasini, R., Frey, F., Flury, W., Klose, G., Greten, H. N. Engl. J. Med. (1977) [Pubmed]
  14. Increased ureagenesis and impaired nitrogen use during infusion of a synthetic amino acid formula: a controlled trial. Smith, J.L., Arteaga, C., Heymsfield, S.B. N. Engl. J. Med. (1982) [Pubmed]
  15. Biotin for neurologic disorders of uremia. Yatzidis, H., Koutsicos, D., Alaveras, A.G., Papastephanidis, C., Frangos-Plemenos, M. N. Engl. J. Med. (1981) [Pubmed]
  16. The anemia of chronic renal failure in sheep. Response to erythropoietin-rich plasma in vivo. Eschbach, J.W., Mladenovic, J., Garcia, J.F., Wahl, P.W., Adamson, J.W. J. Clin. Invest. (1984) [Pubmed]
  17. Role of leptin and melanocortin signaling in uremia-associated cachexia. Cheung, W., Yu, P.X., Little, B.M., Cone, R.D., Marks, D.L., Mak, R.H. J. Clin. Invest. (2005) [Pubmed]
  18. Influence of uremia and hemodialysis on the turnover and metabolic effects of glucagon. Sherwin, R.S., Bastl, C., Finkelstein, F.O., Fisher, M., Black, H., Hendler, R., Felig, P. J. Clin. Invest. (1976) [Pubmed]
  19. Effect of parathyroid hormone and uremia on peripheral nerve calcium and motor nerve conduction velocity. Goldstein, D.A., Chui, L.A., Massry, S.G. J. Clin. Invest. (1978) [Pubmed]
  20. Abnormalities of cytoplasmic Ca2+ in platelets from patients with uremia. Ware, J.A., Clark, B.A., Smith, M., Salzman, E.W. Blood (1989) [Pubmed]
  21. Effect of chronic renal failure on Na,K-ATPase alpha 1 and alpha 2 mRNA transcription in rat skeletal muscle. Bonilla, S., Goecke, I.A., Bozzo, S., Alvo, M., Michea, L., Marusic, E.T. J. Clin. Invest. (1991) [Pubmed]
  22. Glucose intolerance in uremia. Quantification of pancreatic beta cell sensitivity to glucose and tissue sensitivity to insulin. DeFronzo, R.A., Tobin, J.D., Rowe, J.W., Andres, R. J. Clin. Invest. (1978) [Pubmed]
  23. Glucagon-stimulable adenylyl cyclase in rat liver. Effects of chronic uremia and intermittent glucagon administration. Dighe, R.R., Rojas, F.J., Birnbaumer, L., Garber, A.J. J. Clin. Invest. (1984) [Pubmed]
  24. Aorto-left renal vein fistula: an unusual complication of abdominal aortic aneurysm. Suzuki, M., Collins, G.M., Bassinger, G.T., Dilley, R.B. Ann. Surg. (1976) [Pubmed]
  25. A role of parathyroid hormone for the activation of cardiac fibroblasts in uremia. Amann, K., Ritz, E., Wiest, G., Klaus, G., Mall, G. J. Am. Soc. Nephrol. (1994) [Pubmed]
  26. Effect of parathyroid hormone on erythropoiesis. Meytes, D., Bogin, E., Ma, A., Dukes, P.P., Massry, S.G. J. Clin. Invest. (1981) [Pubmed]
  27. Thiol S-methylation in uremia: erythrocyte enzyme activities and plasma inhibitors. Pazmiño, P.A., Sladek, S.L., Weinshilboum, R.M. Clin. Pharmacol. Ther. (1980) [Pubmed]
  28. Decreased hepatic insulin-like growth factor (IGF)-I and increased IGF binding protein-1 and -2 gene expression in experimental uremia. Tönshoff, B., Powell, D.R., Zhao, D., Durham, S.K., Coleman, M.E., Domené, H.M., Blum, W.F., Baxter, R.C., Moore, L.C., Kaskel, F.J. Endocrinology (1997) [Pubmed]
  29. Hypoperfusion-induced acute renal failure in the rat: an evaluation of oxidant tissue injury. Zager, R.A. Circ. Res. (1988) [Pubmed]
  30. Pathogenesis of cyclosporine nephropathy: roles of angiotensin II and osteopontin. Pichler, R.H., Franceschini, N., Young, B.A., Hugo, C., Andoh, T.F., Burdmann, E.A., Shankland, S.J., Alpers, C.E., Bennett, W.M., Couser, W.G. J. Am. Soc. Nephrol. (1995) [Pubmed]
  31. Radioimmunoassay for the middle region of human parathyroid hormone: studies with a radioiodinated synthetic peptide. Marx, S.J., Sharp, M.E., Krudy, A., Rosenblatt, M., Mallette, L.E. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  32. Decreased plasma protein binding of diazoxide in uremia. O'Malley, K., Velasco, M., Pruitt, A., McNay, J.L. Clin. Pharmacol. Ther. (1975) [Pubmed]
  33. Circadian rhythm of blood pressure in normotensive NIDDM subjects. Its relationship to microvascular complications. Nakano, S., Uchida, K., Kigoshi, T., Azukizawa, S., Iwasaki, R., Kaneko, M., Morimoto, S. Diabetes Care (1991) [Pubmed]
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