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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Serum Response Element

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Disease relevance of Serum Response Element


High impact information on Serum Response Element


Chemical compound and disease context of Serum Response Element


Biological context of Serum Response Element


Anatomical context of Serum Response Element


Associations of Serum Response Element with chemical compounds


Gene context of Serum Response Element


Analytical, diagnostic and therapeutic context of Serum Response Element


  1. Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase. Miranti, C.K., Ginty, D.D., Huang, G., Chatila, T., Greenberg, M.E. Mol. Cell. Biol. (1995) [Pubmed]
  2. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. Ebert, B.L., Firth, J.D., Ratcliffe, P.J. J. Biol. Chem. (1995) [Pubmed]
  3. Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. Duan, R., Xie, W., Burghardt, R.C., Safe, S. J. Biol. Chem. (2001) [Pubmed]
  4. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. An, S., Zheng, Y., Bleu, T. J. Biol. Chem. (2000) [Pubmed]
  5. A role for the small GTPase Rac in polyomavirus middle-T antigen-mediated activation of the serum response element and in cell transformation. Urich, M., Senften, M., Shaw, P.E., Ballmer-Hofer, K. Oncogene (1997) [Pubmed]
  6. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Wary, K.K., Mainiero, F., Isakoff, S.J., Marcantonio, E.E., Giancotti, F.G. Cell (1996) [Pubmed]
  7. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Hill, C.S., Wynne, J., Treisman, R. Cell (1995) [Pubmed]
  8. Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Dalton, S., Treisman, R. Cell (1994) [Pubmed]
  9. Functional analysis of a growth factor-responsive transcription factor complex. Hill, C.S., Marais, R., John, S., Wynne, J., Dalton, S., Treisman, R. Cell (1993) [Pubmed]
  10. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Norman, C., Runswick, M., Pollock, R., Treisman, R. Cell (1988) [Pubmed]
  11. Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. Babu, G.J., Lalli, M.J., Sussman, M.A., Sadoshima, J., Periasamy, M. J. Mol. Cell. Cardiol. (2000) [Pubmed]
  12. Integration of MAP kinase signal transduction pathways at the serum response element. Whitmarsh, A.J., Shore, P., Sharrocks, A.D., Davis, R.J. Science (1995) [Pubmed]
  13. A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes. Passmore, S., Elble, R., Tye, B.K. Genes Dev. (1989) [Pubmed]
  14. Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. Cavigelli, M., Dolfi, F., Claret, F.X., Karin, M. EMBO J. (1995) [Pubmed]
  15. Identification and purification of a polypeptide that binds to the c-fos serum response element. Treisman, R. EMBO J. (1987) [Pubmed]
  16. The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. Mainiero, F., Murgia, C., Wary, K.K., Curatola, A.M., Pepe, A., Blumemberg, M., Westwick, J.K., Der, C.J., Giancotti, F.G. EMBO J. (1997) [Pubmed]
  17. Transcriptional regulatory elements downstream of the JunB gene. Perez-Albuerne, E.D., Schatteman, G., Sanders, L.K., Nathans, D. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  18. Homer-3 regulates activation of serum response element in T cells via its EVH1 domain. Ishiguro, K., Xavier, R. Blood (2004) [Pubmed]
  19. Calmodulin and calmodulin-dependent kinase IIalpha regulate osteoblast differentiation by controlling c-fos expression. Zayzafoon, M., Fulzele, K., McDonald, J.M. J. Biol. Chem. (2005) [Pubmed]
  20. Nuclear signaling by endothelin-1. A Ras pathway for activation of the c-fos serum response element. Herman, W.H., Simonson, M.S. J. Biol. Chem. (1995) [Pubmed]
  21. Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1. MacLellan, W.R., Lee, T.C., Schwartz, R.J., Schneider, M.D. J. Biol. Chem. (1994) [Pubmed]
  22. The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP. Gilman, M.Z. Genes Dev. (1988) [Pubmed]
  23. Synergism in ternary complex formation between the dimeric glycoprotein p67SRF, polypeptide p62TCF and the c-fos serum response element. Schröter, H., Mueller, C.G., Meese, K., Nordheim, A. EMBO J. (1990) [Pubmed]
  24. H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. Meyer, M., Schreck, R., Baeuerle, P.A. EMBO J. (1993) [Pubmed]
  25. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Rivera, V.M., Miranti, C.K., Misra, R.P., Ginty, D.D., Chen, R.H., Blenis, J., Greenberg, M.E. Mol. Cell. Biol. (1993) [Pubmed]
  26. Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Sadoshima, J., Izumo, S. Circ. Res. (1993) [Pubmed]
  27. Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2. Theis, M.G., Knorre, A., Kellersch, B., Moelleken, J., Wieland, F., Kolanus, W., Famulok, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  28. Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element. Soh, J.W., Lee, E.H., Prywes, R., Weinstein, I.B. Mol. Cell. Biol. (1999) [Pubmed]
  29. Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways. Chung, K.C., Gomes, I., Wang, D., Lau, L.F., Rosner, M.R. Mol. Cell. Biol. (1998) [Pubmed]
  30. The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation. Wu, J.J., Zhang, L., Bennett, A.M. Mol. Cell. Biol. (2005) [Pubmed]
  31. Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction. Stein, B., Cogswell, P.C., Baldwin, A.S. Mol. Cell. Biol. (1993) [Pubmed]
  32. Functional identification of the transcriptional regulatory elements within the promoter region of the human ventricular myosin alkali light chain gene. Kurabayashi, M., Komuro, I., Shibasaki, Y., Tsuchimochi, H., Takaku, F., Yazaki, Y. J. Biol. Chem. (1990) [Pubmed]
  33. Quantitative analysis of the contribution made by 5'-flanking and 3'-flanking sequences to the transcriptional regulation of junB by growth factors. Phinney, D.G., Keiper, C.L., Francis, M.K., Ryder, K. Oncogene (1994) [Pubmed]
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