Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Floxacrina 7-chloro-10-hydroxy-3-[4...

Synonyms: Floxacrine, Floxacrinum, HOE-991, CHEMBL333634, SureCN2109331, ...

Raether, W. et al., Königk, E. et al., Raether, W. et al.

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Disease relevance of Floxacrine

Suppressive and causal prophylactic activity of floxacrine in various avian malaria models [1].

High impact information on Floxacrine

Action of a new floxacrine derivative (S 82 5455) on asexual stages of Plasmodium berghei: a light and electron microscopical study [2].
In vitro floxacrine revealed no effect against sporozoites of P. gallinaceum even at concentrations of 100 mcg/ml [1].
Ornithine decarboxylase activity was inhibited in Plasmodium chabaudi-infected red cells of mice treated with chloroquine, mefloquine, primaquine and floxacrine [3].

References

Suppressive and causal prophylactic activity of floxacrine in various avian malaria models. Raether, W., Hofmann, J., Fink, E. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectiousdiseases, para... (1981) [Pubmed]
Action of a new floxacrine derivative (S 82 5455) on asexual stages of Plasmodium berghei: a light and electron microscopical study. Raether, W., Mehlhorn, H. Zentralblatt für Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology. (1984) [Pubmed]
Plasmodium chabaudi-infection of mice: effects of chloroquine and mefloquine. Inhibition of ornithine decarboxylase activity. Königk, E., Mirtsch, S., Putfarken, B., Abdel-Rasoul, S. Tropenmedizin und Parasitologie. (1981) [Pubmed]

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