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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Malaria, Avian

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High impact information on Malaria, Avian

  • A chitinase gene, PgCHT1, recently has been identified in the avian malaria parasite P. gallinaceum [1].
  • The histidine-rich protein (HRP) of the avian malaria parasite Plasmodium lophurae contains 70% histidine [2].
  • We have purified a chitinase of the avian malaria parasite Plasmodium gallinaceum and cloned the gene, PgCHT1, encoding it [3].
  • A fragment of the mitochondrial cytochrome b gene of avian malaria (genera Haemoproteus and Plasmodium) was amplified from blood samples of 12 species of passerine birds from the genera Acrocephalus, Phylloscopus and Parus [4].
  • To add to the body of molecular data, we sequenced three genes (cytochrome b, 18 SSU rRNA, caseinolytic protease C) of different organellar origin of one of the most widespread avian malaria parasites, Plasmodium (Haemamoeba) cathemerium, which once used to be an important laboratory in vivo model in human malaria research [5].

Chemical compound and disease context of Malaria, Avian

  • Plasmodium chitinase activities are demonstrated targets for human and avian malaria transmission blockade with the chitinase inhibitor allosamidin [6].
  • Analysis of sensitivity, specificity, and negative and positive predictive values (PPVs) showed that gamma-glutamyltranspeptidase (GGTP), alanine aminotransferase (ALT), and creatinine reached PPVs and a specificity over 57% for avian malaria infections in penguins [7].
  • Suppressive and causal prophylactic activity of floxacrine in various avian malaria models [8].

Gene context of Malaria, Avian


  1. The chitinase PfCHT1 from the human malaria parasite Plasmodium falciparum lacks proenzyme and chitin-binding domains and displays unique substrate preferences. Vinetz, J.M., Dave, S.K., Specht, C.A., Brameld, K.A., Xu, B., Hayward, R., Fidock, D.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. In vitro translation and characterization of a unique histidine-rich protein mRNA in the avian malaria parasite Plasmodium lophurae. Wallach, M., Boeke, J.D. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  3. Chitinases of the avian malaria parasite Plasmodium gallinaceum, a class of enzymes necessary for parasite invasion of the mosquito midgut. Vinetz, J.M., Valenzuela, J.G., Specht, C.A., Aravind, L., Langer, R.C., Ribeiro, J.M., Kaslow, D.C. J. Biol. Chem. (2000) [Pubmed]
  4. Host specificity in avian blood parasites: a study of Plasmodium and Haemoproteus mitochondrial DNA amplified from birds. Bensch, S., Stjernman, M., Hasselquist, D., Ostman, O., Hansson, B., Westerdahl, H., Pinheiro, R.T. Proc. Biol. Sci. (2000) [Pubmed]
  5. Plasmodium (Haemamoeba) cathemerium gene sequences for phylogenetic analysis of malaria parasites. Wiersch, S.C., Maier, W.A., Kampen, H. Parasitol. Res. (2005) [Pubmed]
  6. Knockout of the rodent malaria parasite chitinase pbCHT1 reduces infectivity to mosquitoes. Dessens, J.T., Mendoza, J., Claudianos, C., Vinetz, J.M., Khater, E., Hassard, S., Ranawaka, G.R., Sinden, R.E. Infect. Immun. (2001) [Pubmed]
  7. Evaluation of serum chemistry values associated with avian malaria infections in African black-footed penguins (Spheniscus demersus). Graczyk, T.K., Cranfield, M.R., Bicknese, E.J. Parasitol. Res. (1995) [Pubmed]
  8. Suppressive and causal prophylactic activity of floxacrine in various avian malaria models. Raether, W., Hofmann, J., Fink, E. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectiousdiseases, para... (1981) [Pubmed]
  9. Immunological cross-reactivity of the histidine-rich protein of Plasmodium lophurae and the knob protein of Plasmodium falciparum. Kilejian, A. J. Parasitol. (1983) [Pubmed]
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