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Chemical Compound Review:

Nikethan ethyl pyridine-3-carboxylate

Synonyms: Nikithan, Ignicut, Ignocut, Mucotherm, Nicaethan, ...

Sugibayashi, K. et al., Ngawhirunpat, T. et al., Rittirod, T. et al., Rittirod, T. et al.

Sugibayashi, Hayashi, Matsumoto, Hasegawa,

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High impact information on Ignicut

The simultaneous diffusion and metabolism of ethyl nicotinate (EN) in a cultured human skin model, Living Skin Equivalent-high, was evaluated by the in vitro skin permeation and metabolism experiments, and esterase distribution was also determined [1].
In vitro hydrolysis of ethyl nicotinate (EN), an esterified prodrug of nicotinic acid, was investigated in homogenate of cultured keratinocytes, and the Michaelis-Menten parameters (V(max) and K(m)) of EN were evaluated [2].
In vitro simultaneous transport and metabolism of three ester prodrugs of nicotinic acid (NA), methyl nicotinate (MN), ethyl nicotinate (EN) and butyl nicotinate (BN) were studied using excised skin from hairless mouse [3].

Analytical, diagnostic and therapeutic context of Ignicut

The objective of this research was to compare the characteristics of skin permeation and metabolism of ethyl nicotinate (EN) among humans and several animal models [4].

References

Utility of a three-dimensional cultured human skin model as a tool to evaluate the simultaneous diffusion and metabolism of ethyl nicotinate in skin. Sugibayashi, K., Hayashi, T., Matsumoto, K., Hasegawa, T. Drug Metab. Pharmacokinet. (2004) [Pubmed]
Age dependency of esterase activity in rat and human keratinocytes. Ngawhirunpat, T., Kawakami, N., Hatanaka, T., Kawakami, J., Adachi, I. Biol. Pharm. Bull. (2003) [Pubmed]
Simultaneous transport and metabolism of nicotinic acid derivatives in hairless mouse skin. Rittirod, T., Hatanaka, T., Kagami, N., Katayama, K., Koizumi, T. Biol. Pharm. Bull. (1999) [Pubmed]
Species difference in simultaneous transport and metabolism of ethyl nicotinate in skin. Rittirod, T., Hatanaka, T., Uraki, A., Hino, K., Katayama, K., Koizumi, T. International journal of pharmaceutics. (1999) [Pubmed]

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