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MeSH Review

Mice, Inbred HRS

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Disease relevance of Mice, Inbred HRS


High impact information on Mice, Inbred HRS

  • Tumour promotion by TCDD in skin of HRS/J hairless mice [6].
  • The most striking defect is brittle hair resulting in alopecia (hairless mice) [7].
  • Using a hairless mouse model, we have demonstrated that testosterone reduction stimulates the healing response not through hair follicle epithelial/mesenchymal cell proliferation, but directly via effects on wound cell populations [8].
  • We show here that topical application of TNF after experimental injury to the SC of hairless mice (hr(-/-)) enhances barrier repair [9].
  • Because tumor necrosis factor (TNF) and other cytokines are known products of keratinocytes and have been shown to modulate lipid and DNA synthesis in other systems, their levels were examined in two acute models and one chronic model of barrier perturbation in hairless mice [10].

Chemical compound and disease context of Mice, Inbred HRS


Biological context of Mice, Inbred HRS


Anatomical context of Mice, Inbred HRS


Associations of Mice, Inbred HRS with chemical compounds


Gene context of Mice, Inbred HRS


Analytical, diagnostic and therapeutic context of Mice, Inbred HRS


  1. Stratum corneum lipids in disorders of cornification. Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X-linked ichthyosis. Elias, P.M., Williams, M.L., Maloney, M.E., Bonifas, J.A., Brown, B.E., Grayson, S., Epstein, E.H. J. Clin. Invest. (1984) [Pubmed]
  2. Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells. Berg, R.J., van Kranen, H.J., Rebel, H.G., de Vries, A., van Vloten, W.A., Van Kreijl, C.F., van der Leun, J.C., de Gruijl, F.R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Oxidation of retinol to retinoic acid as a requirement for biological activity in mouse epidermis. Connor, M.J. Cancer Res. (1988) [Pubmed]
  4. Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation. Alekseev, S., Kool, H., Rebel, H., Fousteri, M., Moser, J., Backendorf, C., de Gruijl, F.R., Vrieling, H., Mullenders, L.H. Cancer Res. (2005) [Pubmed]
  5. Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds. de Clercq, E. Antimicrob. Agents Chemother. (1984) [Pubmed]
  6. Tumour promotion by TCDD in skin of HRS/J hairless mice. Poland, A., Palen, D., Glover, E. Nature (1982) [Pubmed]
  7. Hoxc13 mutant mice lack external hair. Godwin, A.R., Capecchi, M.R. Genes Dev. (1998) [Pubmed]
  8. Androgen receptor-mediated inhibition of cutaneous wound healing. Ashcroft, G.S., Mills, S.J. J. Clin. Invest. (2002) [Pubmed]
  9. Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. Jensen, J.M., Schütze, S., Förl, M., Krönke, M., Proksch, E. J. Clin. Invest. (1999) [Pubmed]
  10. Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. Wood, L.C., Jackson, S.M., Elias, P.M., Grunfeld, C., Feingold, K.R. J. Clin. Invest. (1992) [Pubmed]
  11. Effects of retinoids on phorbol ester-stimulated epidermal DNA synthesis and hyperplasia in hairless mice. Gendimenico, G.J., Nair, X., Bouquin, P.L., Tramposch, K.M. J. Invest. Dermatol. (1989) [Pubmed]
  12. Substitution of equally carcinogenic UV-A for UV-B irradiations lowers epidermal thymine dimer levels during skin cancer induction in hairless mice. Berg, R.J., de Laat, A., Roza, L., van der Leun, J.C., de Gruijl, F.R. Carcinogenesis (1995) [Pubmed]
  13. Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by acycloguanosine. Klein, R.J., Friedman-Kien, A.E., DeStefano, E. Antimicrob. Agents Chemother. (1979) [Pubmed]
  14. Xylotubercidin against herpes simplex virus type 2 in mice. De Clercq, E., Robins, M.J. Antimicrob. Agents Chemother. (1986) [Pubmed]
  15. Iontophoretic application of adenine arabinoside monophosphate for the treatment of herpes simplex virus type 2 skin infections in hairless mice. Kwon, B.S., Hill, J.M., Wiggins, C., Tuggle, C. J. Infect. Dis. (1979) [Pubmed]
  16. Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin. Reagan-Shaw, S., Afaq, F., Aziz, M.H., Ahmad, N. Oncogene (2004) [Pubmed]
  17. Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless mice. Afaq, F., Ahmad, N., Mukhtar, H. Oncogene (2003) [Pubmed]
  18. Activation of telomerase and its association with G1-phase of the cell cycle during UVB-induced skin tumorigenesis in SKH-1 hairless mouse. Balasubramanian, S., Kim, K.H., Ahmad, N., Mukhtar, H. Oncogene (1999) [Pubmed]
  19. Diffusion of [2-14C]diazepam across hairless mouse skin and human skin. Koch, R.L., Palicharla, P., Groves, M.J. J. Invest. Dermatol. (1987) [Pubmed]
  20. Effect of retinoic acid pretreatment on 12-O-tetradecanoylphorbol-13-acetate-induced cell population kinetics and polyamine biosynthesis in hairless mouse epidermis. Astrup, E.G., Paulsen, J.E. Carcinogenesis (1982) [Pubmed]
  21. Topical tretinoin increases the tropoelastin and fibronectin content of photoaged hairless mouse skin. Schwartz, E., Kligman, L.H. J. Invest. Dermatol. (1995) [Pubmed]
  22. Cytochrome P-450 dependent deethylase activity in rat and hairless mouse skin microsomes. Moloney, S.J., Fromson, J.M., Bridges, J.W. Biochem. Pharmacol. (1982) [Pubmed]
  23. Effects of all-trans-retinoic acid on the dermis of hairless mice. Kligman, L.H. J. Am. Acad. Dermatol. (1986) [Pubmed]
  24. Ultraviolet B radiation increases hairless mouse mast cells in a dose-dependent manner and alters distribution of UV-induced mast cell growth factor. Kligman, L.H., Murphy, G.F. Photochem. Photobiol. (1996) [Pubmed]
  25. Enhancement of the granulation tissue formation in hairless mice by a potent vitamin D receptor agonist--KH 1060. Gniadecki, R., Serup, J. J. Endocrinol. (1994) [Pubmed]
  26. Effects of mechlorethamine (HN2, nitrogen mustard) on UV-induced carcinogenesis in hairless mouse skin. Epstein, J.H. J. Natl. Cancer Inst. (1984) [Pubmed]
  27. Diagnostic ultrasound activation of contrast agent gas bodies induces capillary rupture in mice. Miller, D.L., Quddus, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  28. Induction of ornithine decarboxylase activity and DNA synthesis in hairless mouse epidermis by retinoids. Connor, M.J., Lowe, N.J. Cancer Res. (1983) [Pubmed]
  29. Induction and persistence of pyrimidine dimers in the epidermal DNA of two strains of hairless mice. Ley, R.D., Sedita, A., Grube, D.D., Fry, R.J. Cancer Res. (1977) [Pubmed]
  30. Inhibition of ultraviolet-B epidermal ornithine decarboxylase induction and skin carcinogenesis in hairless mice by topical indomethacin and triamcinolone acetonide. Lowe, N.J., Connor, M.J., Breeding, J., Chalet, M. Cancer Res. (1982) [Pubmed]
  31. A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice. Holick, M.F., Ray, S., Chen, T.C., Tian, X., Persons, K.S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  32. Cyclooxygenase-1 deletion enhances apoptosis but does not protect against ultraviolet light-induced tumors. Pentland, A.P., Scott, G., VanBuskirk, J., Tanck, C., LaRossa, G., Brouxhon, S. Cancer Res. (2004) [Pubmed]
  33. Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice. van Kranen, H.J., de Gruijl, F.R., de Vries, A., Sontag, Y., Wester, P.W., Senden, H.C., Rozemuller, E., van Kreijl, C.F. Carcinogenesis (1995) [Pubmed]
  34. Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. Mao-Qiang, M., Fowler, A.J., Schmuth, M., Lau, P., Chang, S., Brown, B.E., Moser, A.H., Michalik, L., Desvergne, B., Wahli, W., Li, M., Metzger, D., Chambon, P.H., Elias, P.M., Feingold, K.R. J. Invest. Dermatol. (2004) [Pubmed]
  35. Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing. Man, M.Q., Choi, E.H., Schmuth, M., Crumrine, D., Uchida, Y., Elias, P.M., Holleran, W.M., Feingold, K.R. J. Invest. Dermatol. (2006) [Pubmed]
  36. Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention. Khan, S.G., Katiyar, S.K., Agarwal, R., Mukhtar, H. Cancer Res. (1992) [Pubmed]
  37. Comparative ultrastructure and cytochemistry of epidermal responses to tape stripping, ethanol and vitamin A acid in hairless mice. Brown, W.R., Habowsky, J.E. J. Invest. Dermatol. (1979) [Pubmed]
  38. Ultraviolet B-induced apoptosis of keratinocytes in murine skin is reduced by mild local hyperthermia. Kane, K.S., Maytin, E.V. J. Invest. Dermatol. (1995) [Pubmed]
  39. Repair of pyrimidine(6-4)pyrimidone photoproducts in mouse skin. Mitchell, D.L., Cleaver, J.E., Epstein, J.H. J. Invest. Dermatol. (1990) [Pubmed]
  40. Induction, repair and accumulation of thymine dimers in the skin of UV-B-irradiated hairless mice. Vink, A.A., Berg, R.J., de Gruijl, F.R., Roza, L., Baan, R.A. Carcinogenesis (1991) [Pubmed]
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