Disease relevance of diphenylmethanol

• Studies on structure-activity relationships revealed that compounds having an electron-withdrawing group in the benzhydril or benzhydrol moiety, and specifically those having the beta-D-xylopyranosyl structure in the sugar moiety, were good antithrombotic agents in a rat model of venous thrombosis [1].

High impact information on diphenylmethanol

• Benzyl and benzhydryl alcohol compounds 40-48 are more active than amino structures 27 and 35-38 and also exhibit excellent in vivo activity in the CAR test with modest D2 and 5-HT1A receptor binding [2].
• Although the corresponding benzophenone 18 was as active as 1a as a tubulin polymerization inhibitor, it was less cytotoxic than 1a, and the benzhydrol 19 was essentially inactive [3].
• The thioxanthone-sensitized reaction of P1 with benzhydrol was studied in detail by a combination of steady state and transient kinetics [4].
• These results suggest that benzophenone and its metabolically related benzhydrol and p-benzoylphenol can be bioactivated by P450 2A6 and P450 family 1 enzymes [5].
• Alkylation by secondary alcohols III: Fusion of medicinal sulfanilamides with benzhydrol [6].

Associations of diphenylmethanol with other chemical compounds

• Liquid-liquid extraction and preparative thin-layer chromatography were used to isolate 30 micromoles of benzhydrol from the beta-glucuronidase treated 24 hour urine of rats administered 5.3 mmoles of diphenylmethane [7].

References