Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Mafoprazina N-[4-[3-[4-(2- fluorophenyl)piperazin-1...

Synonyms: Mafoprazine, Mafoprazinum, CHEMBL2105101, SureCN2111008, AC1L2FTB, ...

Yamamura, M. et al., Yamamura, M. et al.

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Disease relevance of Mafoprazine

Mafoprazine showed cataleptogenicity in rats at 5 mg/kg, s.c. or more and motor incoordination in rats at 0.2 mg/kg, s.c. or more [1].

High impact information on Mafoprazine

These results suggest that mafoprazine has a relatively selective postsynaptic dopamine D2-receptor blocking action in the nucleus accumbens compared with chlorpromazine and haloperidol and suggest that mafoprazine also has alpha 2-adrenoceptor-stimulating actions [2].

References

A behavioral pharmacological study of mafoprazine, a new phenylpiperazine derivative. Yamamura, M., Nakagawa, H., Kinoshita, K., Ochiai, T., Ishida, R. Jpn. J. Pharmacol. (1988) [Pubmed]
Effects of mafoprazine, a phenylpiperazine derivative, on the central dopaminergic system. Yamamura, M., Nakagawa, H., Maeda, K., Kinoshita, K., Ishida, R. Jpn. J. Pharmacol. (1989) [Pubmed]

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