Gene Review:
Drd2 - dopamine receptor D2
Mus musculus
Synonyms:
D(2) dopamine receptor, D2 receptor, D2R, Dopamine D2 receptor, Drd-2
Risinger,
Freeman,
Rubinstein,
Low,
Grandy,
Drago,
Padungchaichot,
Accili,
Fuchs,
McNamara,
Logue,
Stanford,
Xu,
Zhang,
Richtand,
Rünkorg,
Värv,
Matsui,
Kõks,
Vasar,
Takeuchi,
Fukunaga,
Kruzich,
Grandy,
Schiffmann,
Dassesse,
d'Alcantara,
Ledent,
Swillens,
Zoli,
Hitzemann,
Hitzemann,
Rivera,
Gatley,
Thanos,
Shou,
Williams,
Buck,
Lischka,
Dorow,
Crabbe,
- Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms. Schuff, K.G., Hentges, S.T., Kelly, M.A., Binart, N., Kelly, P.A., Iuvone, P.M., Asa, S.L., Low, M.J. J. Clin. Invest. (2002)
- Rescue of locomotor impairment in dopamine D2 receptor-deficient mice by an adenosine A2A receptor antagonist. Aoyama, S., Kase, H., Borrelli, E. J. Neurosci. (2000)
- Dopaminergic D2 receptor knockout mouse: an animal model of prolactinoma. Cristina, C., García-Tornadú, I., Díaz-Torga, G., Rubinstein, M., Low, M.J., Becú-Villalobos, D. Frontiers of hormone research. (2006)
- Mapping quantitative trait loci that regulate sensitivity and tolerance to quinpirole, a dopamine mimetic selective for D(2)/D(3) receptors. Buck, K., Lischka, T., Dorow, J., Crabbe, J. Am. J. Med. Genet. (2000)
- Effects of age and dopamine D2L receptor-deficiency on motor and learning functions. Fetsko, L.A., Xu, R., Wang, Y. Neurobiol. Aging (2005)
- Dopamine D2L receptor knockout mice display deficits in positive and negative reinforcing properties of morphine and in avoidance learning. Smith, J.W., Fetsko, L.A., Xu, R., Wang, Y. Neuroscience (2002)
- Influence of the dopamine D2 receptor knockout on pain-related behavior in the mouse. Mansikka, H., Erbs, E., Borrelli, E., Pertovaara, A. Brain Res. (2005)
- Dopamine D2 receptors mediate two-odor discrimination and reversal learning in C57BL/6 mice. Kruzich, P.J., Grandy, D.K. BMC neuroscience [electronic resource]. (2004)
- In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets. Zhai, W., Jeong, H., Cui, L., Krainc, D., Tjian, R. Cell (2005)
- Decoding dopamine signaling. Bibb, J.A. Cell (2005)
- Par-4 links dopamine signaling and depression. Park, S.K., Nguyen, M.D., Fischer, A., Luke, M.P., Affar, e.l. .B., Dieffenbach, P.B., Tseng, H.C., Shi, Y., Tsai, L.H. Cell (2005)
- Distinct functions of the two isoforms of dopamine D2 receptors. Usiello, A., Baik, J.H., Rougé-Pont, F., Picetti, R., Dierich, A., LeMeur, M., Piazza, P.V., Borrelli, E. Nature (2000)
- Absence of opiate rewarding effects in mice lacking dopamine D2 receptors. Maldonado, R., Saiardi, A., Valverde, O., Samad, T.A., Roques, B.P., Borrelli, E. Nature (1997)
- Altered GABAergic neurotransmission in mice lacking dopamine D2 receptors. An, J.J., Bae, M.H., Cho, S.R., Lee, S.H., Choi, S.H., Lee, B.H., Shin, H.S., Kim, Y.N., Park, K.W., Borrelli, E., Baik, J.H. Mol. Cell. Neurosci. (2004)
- Ovarian dependence for pituitary tumorigenesis in D2 dopamine receptor-deficient mice. Hentges, S.T., Low, M.J. Endocrinology (2002)
- Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice. Chausmer, A.L., Elmer, G.I., Rubinstein, M., Low, M.J., Grandy, D.K., Katz, J.L. Psychopharmacology (Berl.) (2002)
- Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis. Palmer, A.A., Low, M.J., Grandy, D.K., Phillips, T.J. Behav. Genet. (2003)
- Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes. Hitzemann, R., Hitzemann, B., Rivera, S., Gatley, J., Thanos, P., Shou, L.L., Williams, R.W. Alcohol. Clin. Exp. Res. (2003)
- Differences in behavioural effects of amphetamine and dopamine-related gene expression in wild-type and homozygous CCK(2) receptor deficient mice. Rünkorg, K., Värv, S., Matsui, T., Kõks, S., Vasar, E. Neurosci. Lett. (2006)
- Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites. Lindgren, N., Usiello, A., Goiny, M., Haycock, J., Erbs, E., Greengard, P., Hokfelt, T., Borrelli, E., Fisone, G. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants. Drago, J., Padungchaichot, P., Accili, D., Fuchs, S. Dev. Neurosci. (1998)
- D1 and D2 receptor antagonist injections in the prefrontal cortex selectively impair spatial learning in mice. Rinaldi, A., Mandillo, S., Oliverio, A., Mele, A. Neuropsychopharmacology (2007)
- Neurons exhibiting dopamine D2 receptor immunoreactivity in the substantia nigra of the mutant weaver mouse. Xu, S.G., Prasad, C., Smith, D.E. Neuroscience (1999)
- Amphetamine discrimination: effects of dopamine receptor agonists. Nielsen, E.B., Randrup, K., Andersen, P.H. Eur. J. Pharmacol. (1989)
- Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamine. McNamara, R.K., Logue, A., Stanford, K., Xu, M., Zhang, J., Richtand, N.M. Synapse (2006)
- Locomotor behavior of dopamine D1 receptor transgenic/D2 receptor deficient hybrid mice. Dracheva, S., Haroutunian, V. Brain Res. (2001)
- Different effects of five dopamine receptor subtypes on nuclear factor-kappaB activity in NG108-15 cells and mouse brain. Takeuchi, Y., Fukunaga, K. J. Neurochem. (2004)
- A2A receptor and striatal cellular functions: regulation of gene expression, currents, and synaptic transmission. Schiffmann, S.N., Dassesse, D., d'Alcantara, P., Ledent, C., Swillens, S., Zoli, M. Neurology (2003)
- Dopamine control of striatal gene expression during development: relevance to knockout mice for the dopamine transporter. Fauchey, V., Jaber, M., Bloch, B., Le Moine, C. Eur. J. Neurosci. (2000)
- Characterization of the human dopamine D3 receptor expressed in transfected cell lines. MacKenzie, R.G., VanLeeuwen, D., Pugsley, T.A., Shih, Y.H., Demattos, S., Tang, L., Todd, R.D., O'Malley, K.L. Eur. J. Pharmacol. (1994)
- Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor. Tillerson, J.L., Caudle, W.M., Parent, J.M., Gong, C., Schallert, T., Miller, G.W. Behav. Brain Res. (2006)
- Selective increase of Nurr1 mRNA expression in mesencephalic dopaminergic neurons of D2 dopamine receptor-deficient mice. Tseng, K.Y., Roubert, C., Do, L., Rubinstein, M., Kelly, M.A., Grandy, D.K., Low, M.J., Gershanik, O.S., Murer, M.G., Giros, B., Raisman-Vozari, R. Brain Res. Mol. Brain Res. (2000)
- GH in the dwarf dopaminergic D2 receptor knockout mouse: somatotrope population, GH release, and responsiveness to GH-releasing factors and somatostatin. Garc??a-Tornad??, I., Rubinstein, M., Gaylinn, B.D., Hill, D., Arany, E., Low, M.J., D??az-Torga, G., Becu-Villalobos, D. J. Endocrinol. (2006)
- Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice. Risinger, F.O., Freeman, P.A., Rubinstein, M., Low, M.J., Grandy, D.K. Psychopharmacology (Berl.) (2000)
- Early expression of D3 dopamine receptors in murine embryonic development. Fishburn, C.S., Bedford, M., Lonai, P., Fuchs, S. FEBS Lett. (1996)