Chemical Compound Review:
Butyvinal 5-ethenyl-5-pentan-2-yl-1,3- diazinane-2,4...
Synonyms:
Butyvinyl, Bykonox, Vinymal, Butylvinal, Vinilbital, ...
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High impact information on Butylvinal
- The average bioavailability of vinylbital for the suppository, relative to the tablet, was approximately 93% [1].
- Pharmacokinetics and relative bioavailability of vinylbital in man after oral and rectal administration [1].
- Tablets (Bykonox) containing 150 mg vinylbital, were used for the oral experiments and suppositories (Suppoptanox, polyethylene glycol base) containing 200 mg vinylbital, were used for rectal administration [1].
Analytical, diagnostic and therapeutic context of Butylvinal
- Absorption and elimination of vinylbital appeared to occur according to a single first-order process and the plasma concentrations were fitted by computer according to the equation intrinsic to the one-compartment open model after oral or rectal administration [1].
- A sensitive and specific method for the quantitative determination of 5-vinyl-5-(1-methylbutyl)-barbituric acid (vinylbital) in plasma was developed, by using gas chromatography with alkali flame ionization detection [1].
- The elimination half-life of vinylbital varied from 17.6 to 33.5 h, with a mean value of 23.5 h for oral administration and 23.8 h for rectal administration [1].
References
- Pharmacokinetics and relative bioavailability of vinylbital in man after oral and rectal administration. Breimer, D.D., de Boer, A.G. Arzneimittel-Forschung. (1976) [Pubmed]
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