Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CPEC 4-amino-1-[(1R,4S,5S)-4,5- dihydroxy-3...

Synonyms: cCyd, Ce-Cyd, CPE-C, CPE-cytosine, CHEMBL63647, ...

De Clercq, E. et al., Agbaria, R. et al.

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Disease relevance of Ce-Cyd

Antiproliferative effects of cyclopentenyl cytosine (NSC 375575) in human glioblastoma cells [1].

High impact information on Ce-Cyd

The putative target enzyme for both the antiviral and antitumor action of Ce-Cyd is assumed to be the CTP synthetase that converts UTP to CTP [2].
Ce-Cyd also has potent cytocidal activity against a number of tumor cell lines [2].
Ce-Cyd should be further pursued, as such and in combination with OMP decarboxylase inhibitors, for its therapeutic potential in the treatment of both viral and neoplastic diseases [2].

References

Antiproliferative effects of cyclopentenyl cytosine (NSC 375575) in human glioblastoma cells. Agbaria, R., Kelley, J.A., Jackman, J., Viola, J.J., Ram, Z., Oldfield, E., Johns, D.G. Oncol. Res. (1997) [Pubmed]
Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase. De Clercq, E., Murase, J., Marquez, V.E. Biochem. Pharmacol. (1991) [Pubmed]

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