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Gene Review

OMP  -  olfactory marker protein

Homo sapiens

Synonyms: Olfactory marker protein, Olfactory neuronal-specific protein
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Disease relevance of OMP

  • These vaccines consisted of Hib capsular polysaccharide polyribosyl-ribitol phosphate (PRP) conjugated to the meningococcal outer membrane protein (OMP) complex (PRP-OMP) and H influenzae oligosaccharide conjugated to a mutant toxin (CRM197) isolated from Corynebacterium diphtheriae (HbOC) [1].
  • Thus the 69-kD OMP of B. pertussis is a protective antigen in mice that elicits specific serum antibody that can transude to the lung [2].
  • Immunization with the 69-kD outer membrane protein (OMP) of Bordetella pertussis protected neonatal mice against lethal respiratory challenge with B. pertussis 18323 [2].
  • The meningococcal class 1 outer membrane protein (OMP) plays an important role in the development of protective immunity against meningococcal infection, and is therefore considered to be a promising candidate antigen (Ag) for a meningococcal vaccine [3].
  • Haemophilus influenzae type b isolates have been subdivided based on differences in major outer membrane protein (OMP) profiles resolved on gradient and modified Laemmli sodium dodecyl sulfate-polyacrylamide gel electrophoresis systems [4].

Psychiatry related information on OMP

  • DESIGN AND MEASUREMENTS: We developed and tested a questionnaire to assess the 5 "microskills" of a OMP faculty development program, and performed faculty self-assessment and resident assessment using the questionnaire 6 to 18 months before and 6 to 18 months after our experiential skills improvement workshop [5].
  • PURPOSE: Length of hospital stay (LOS) of infants treated for neonatal abstinence syndrome (NAS) with methadone was compared to LOS of those treated with an oral morphine preparation (OMP, neonatal morphine solution, or deodorized tincture of opium) [6].
  • Also preventing those anomalies commonly associated with weight-loss diets, such as hunger, weakness, headache caused by ketosis, constipation, or decreased libido, the use of MAP, in conjunction with the ANC/OMP, allowed for mean weight loss of 1.4 kg (3 lb) per week [7].

High impact information on OMP

  • Furthermore, the overlapping peptides could be used to identify the epitopes recognized by OMP-specific T cell clones with known HLA restriction [3].
  • The 69-kD OMP was detected in a preparation of a Takeda acellular vaccine by immunoblot analysis and a serum antibody response to the 69-kD OMP was observed in 18-mo-old children boosted with this preparation of Japanese acellular vaccine [2].
  • METHODS: C57BL/6 mice received clinical H. pylori isolates with different genotypes for the cag PAI and OMP gene switch status, as well as isogenic gene knockout mutants for cagE, oipA, babA2, hopZ, cagE/oipA, or oipA/hopZ [8].
  • RESULTS: We observed a significantly lower density of p75NGFR basal cells (37%) in schizophrenia and increases in GAP43 + postmitotic immature neurons (316%) and ratios of GAP43 + postmitotic immature neurons to p75NGFR + cells (665%) and olfactory marker protein + mature neurons to p75NGFR + basal cells (328%) [9].
  • These results demonstrate in real time with a relevant animal model that H. pylori regulates OMP expression in vivo by using both antigenic variation and phase variation [10].

Chemical compound and disease context of OMP


Biological context of OMP

  • The OMP gene in all species studied lacks canonical TATA and CAAT motifs and introns [16].
  • The expression of the signal transduction components adenylyl cyclase type III and the G-protein alpha subunit G(alpha olf) was sensitive to diphtheria toxin exposure and their levels decreased dramatically preceding the disappearance of the OMP-positive sensory neurons [17].
  • The bulbar phenotype observed in the OMP-null mouse is consistent with this hypothesis [18].
  • Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons [18].
  • Haplotypes were constructed in 28 USH1 families by use of the following polymorphic markers spanning the USH1B locus: D11S787, D11S527, D11S1789, D11S906, D11S4186, and OMP [19].

Anatomical context of OMP


Associations of OMP with chemical compounds

  • A previously unknown 5'nucleotidase (5'-ribonucleotide phosphohydrolase, EC (5'-Nase) specific for orotidine 5'-monophosphate (OMP) hs been discovered [22].
  • OMPase was partially purified and is shown to cleave OMP to orotidine and inorganic phosphate [22].
  • OMPase may be responsible, in part, for the low levels of intracellular "free" OMP and for orotidine accumulation in cells treated with 6-azauridine and patients suffering from aortic aciduria [22].
  • Although the core of OMP decarboxylase is conserved, it has undergone a variety of changes in subunit size or fusion to other protein domains, such as orotate phosphoribosyltransferase, during evolution in different kingdoms [23].
  • Orotidine 5'-phosphate (OMP) decarboxylase has the largest rate enhancement for any known enzyme [23].

Physical interactions of OMP

  • Thus, the potential for C3 binding to Hib is greater in the presence of anti-PRP than in the presence of anti-OMP, probably because of the larger number of binding sites available to the former [13].
  • Human transferrin was shown to bind the 84-kDa OMP alone [24].

Enzymatic interactions of OMP


Regulatory relationships of OMP

  • Cell transfection experiments, on the other hand, demonstrated that the promoters of the genes encoding the OSN-specific OMP and the adhesion molecule L1 are both activated by KLF7 binding to CACCC motifs [26].
  • HGF constitutively produced VEGF and levels were significantly enhanced (P < 0.01) by stimulation with Ve and OMP from A. actinomycetemcomitans and P. gingivalis at concentrations of 10 microg/ml or higher [27].
  • P. gingivalis OMP stimulated PBMCs to express IL-17 at both the mRNA and protein level [28].

Other interactions of OMP


Analytical, diagnostic and therapeutic context of OMP


  1. Interchangeability of conjugated Haemophilus influenzae type b vaccines in infants. Anderson, E.L., Decker, M.D., Englund, J.A., Edwards, K.M., Anderson, P., McInnes, P., Belshe, R.B. JAMA (1995) [Pubmed]
  2. Characterization of the protective capacity and immunogenicity of the 69-kD outer membrane protein of Bordetella pertussis. Shahin, R.D., Brennan, M.J., Li, Z.M., Meade, B.D., Manclark, C.R. J. Exp. Med. (1990) [Pubmed]
  3. Identification of T cell epitopes occurring in a meningococcal class 1 outer membrane protein using overlapping peptides assembled with simultaneous multiple peptide synthesis. Wiertz, E.J., van Gaans-van den Brink, J.A., Gausepohl, H., Prochnicka-Chalufour, A., Hoogerhout, P., Poolman, J.T. J. Exp. Med. (1992) [Pubmed]
  4. Purification and comparison of outer membrane protein P2 from Haemophilus influenzae type b isolates. Munson, R.S., Shenep, J.L., Barenkamp, S.J., Granoff, D.M. J. Clin. Invest. (1983) [Pubmed]
  5. Measuring outcomes of a one-minute preceptor faculty development workshop. Eckstrom, E., Homer, L., Bowen, J.L. Journal of general internal medicine : official journal of the Society for Research and Education in Primary Care Internal Medicine. (2006) [Pubmed]
  6. A retrospective study of length of hospital stay in infants treated for neonatal abstinence syndrome with methadone versus oral morphine preparations. Lainwala, S., Brown, E.R., Weinschenk, N.P., Blackwell, M.T., Hagadorn, J.I. Advances in neonatal care : official journal of the National Association of Neonatal Nurses. (2005) [Pubmed]
  7. Master Amino acid Pattern as substitute for dietary proteins during a weight-loss diet to achieve the body's nitrogen balance equilibrium with essentially no calories. Lucà-Moretti, M., Grandi, A., Lucà, E., Muratori, G., Nofroni, M.G., Mucci, M.P., Gambetta, P., Stimolo, R., Drago, P., Giudice, G., Tamburlin, N. Advances in therapy. (2003) [Pubmed]
  8. Helicobacter pylori infection in mice: Role of outer membrane proteins in colonization and inflammation. Yamaoka, Y., Kita, M., Kodama, T., Imamura, S., Ohno, T., Sawai, N., Ishimaru, A., Imanishi, J., Graham, D.Y. Gastroenterology (2002) [Pubmed]
  9. Dysregulation of olfactory receptor neuron lineage in schizophrenia. Arnold, S.E., Han, L.Y., Moberg, P.J., Turetsky, B.I., Gur, R.E., Trojanowski, J.Q., Hahn, C.G. Arch. Gen. Psychiatry (2001) [Pubmed]
  10. Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques. Solnick, J.V., Hansen, L.M., Salama, N.R., Boonjakuakul, J.K., Syvanen, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  11. A quantitative analysis of C3 binding to O-antigen capsule, lipopolysaccharide, and outer membrane protein of E. coli 0111B4. Joiner, K.A., Goldman, R., Schmetz, M., Berger, M., Hammer, C.H., Frank, M.M., Leive, L. J. Immunol. (1984) [Pubmed]
  12. The orotidine-5'-monophosphate decarboxylase gene of Myxococcus xanthus. Comparison to the OMP decarboxylase gene family. Kimsey, H.H., Kaiser, D. J. Biol. Chem. (1992) [Pubmed]
  13. Complement component 3 binding to Haemophilus influenzae type b in the presence of anticapsular and anti-outer membrane antibodies. Hetherington, S.V., Patrick, C.C. Infect. Immun. (1992) [Pubmed]
  14. Multiple antibiotic resistance in Stenotrophomonas maltophilia: involvement of a multidrug efflux system. Zhang, L., Li, X.Z., Poole, K. Antimicrob. Agents Chemother. (2000) [Pubmed]
  15. Emergence of resistance to carbapenem antibiotics in Pseudomonas aeruginosa. Margaret, B.S., Drusano, G.L., Standiford, H.C. J. Antimicrob. Chemother. (1989) [Pubmed]
  16. Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. Buiakova, O.I., Krishna, N.S., Getchell, T.V., Margolis, F.L. Genomics (1994) [Pubmed]
  17. Conditional ablation of mature olfactory sensory neurons mediated by diphtheria toxin receptor. Chen, H., Kohno, K., Gong, Q. J. Neurocytol. (2005) [Pubmed]
  18. Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons. Buiakova, O.I., Baker, H., Scott, J.W., Farbman, A., Kream, R., Grillo, M., Franzen, L., Richman, M., Davis, L.M., Abbondanzo, S., Stewart, C.L., Margolis, F.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  19. Mutation profile of all 49 exons of the human myosin VIIA gene, and haplotype analysis, in Usher 1B families from diverse origins. Adato, A., Weil, D., Kalinski, H., Pel-Or, Y., Ayadi, H., Petit, C., Korostishevsky, M., Bonne-Tamir, B. Am. J. Hum. Genet. (1997) [Pubmed]
  20. Localization of tyrosine hydroxylase and olfactory marker protein immunoreactivities in the human and macaque olfactory bulb. Smith, R.L., Baker, H., Kolstad, K., Spencer, D.D., Greer, C.A. Brain Res. (1991) [Pubmed]
  21. Regulation of gene expression in the olfactory neuroepithelium: a neurogenetic matrix. Margolis, F.L., Verhaagen, J., Biffo, S., Huang, F.L., Grillo, M. Prog. Brain Res. (1991) [Pubmed]
  22. Isolation and partial characterization of a 5'-nucleotidase specific for orotidine-5'-monophosphate. El Kouni, M.H., Cha, S. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  23. The chemistry of the reaction determines the invariant amino acids during the evolution and divergence of orotidine 5'-monophosphate decarboxylase. Traut, T.W., Temple, B.R. J. Biol. Chem. (2000) [Pubmed]
  24. Characterisation of an outer membrane protein of Moraxella catarrhalis. Mathers, K.E., Goldblatt, D., Aebi, C., Yu, R., Schryvers, A.B., Hansen, E.J. FEMS Immunol. Med. Microbiol. (1997) [Pubmed]
  25. A reversible selection system for UMP synthase gene amplification and deamplification. Suttle, D.P. Somat. Cell Mol. Genet. (1989) [Pubmed]
  26. Identification of genes regulated by transcription factor KLF7 in differentiating olfactory sensory neurons. Kajimura, D., Dragomir, C., Ramirez, F., Laub, F. Gene (2007) [Pubmed]
  27. Enhanced expression of vascular endothelial growth factor by periodontal pathogens in gingival fibroblasts. Suthin, K., Matsushita, K., Machigashira, M., Tatsuyama, S., Imamura, T., Torii, M., Izumi, Y. J. Periodont. Res. (2003) [Pubmed]
  28. Porphyromonas gingivalis antigen preferentially stimulates T cells to express IL-17 but not receptor activator of NF-kappaB ligand in vitro. Oda, T., Yoshie, H., Yamazaki, K. Oral Microbiol. Immunol. (2003) [Pubmed]
  29. Conserved nontypeable Haemophilus influenzae-derived TLR2-binding lipopeptides synergize with IFN-beta to increase cytokine production by resident murine and human alveolar macrophages. Punturieri, A., Copper, P., Polak, T., Christensen, P.J., Curtis, J.L. J. Immunol. (2006) [Pubmed]
  30. Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage proinflammatory cytokines. Berenson, C.S., Murphy, T.F., Wrona, C.T., Sethi, S. Infect. Immun. (2005) [Pubmed]
  31. Leptospiral Outer Membrane Protein Induces Extracellular Matrix Accumulation through a TGF-beta1/Smad-Dependent Pathway. Tian, Y.C., Chen, Y.C., Hung, C.C., Chang, C.T., Wu, M.S., Phillips, A.O., Yang, C.W. J. Am. Soc. Nephrol. (2006) [Pubmed]
  32. Outer membrane protein and lipopolysaccharide heterogeneity among Eikenella corrodens isolates. Chen, C.K., Wilson, M.E. J. Infect. Dis. (1990) [Pubmed]
  33. Human immune response to outer membrane protein CD of Moraxella catarrhalis in adults with chronic obstructive pulmonary disease. Murphy, T.F., Kirkham, C., Liu, D.F., Sethi, S. Infect. Immun. (2003) [Pubmed]
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