Disease relevance of Prodox 146

• Elevated susceptibility of newborn as compared with young rats to 2-tert-butylphenol and 2,4-di-tert-butylphenol toxicity [1].

High impact information on Prodox 146

• In the reaction with 2,4-di-tert-butylphenol (DBP), the trinuclear copper(II, II, III) complex acts as a two-electron oxidant to produce an equimolar amount of the C[bond]C coupling dimer of DBP (3,5,3',5'-tetra-tert-butyl-biphenyl-2,2'-diol) and a bis(mu-hydroxo)dicopper(II) complex [2].
• Recovery percentages were in the range of 73.8-94.4%, the lowest one being for the antioxidant Irgafos 168 due to its transformation into the phosphate form and 2,4-di-tert-butylphenol [3].
• Male Sprague-Dawley rats were fed with 3,5-di-tert-butylphenol, 2,4-di-tert-butylphenol, 4-tert-butyl-2,6-diisopropylphenol, 2-tert-butyl-4-sec-butylphenol or 2-,6-di-tert-butyl-4-methylphenol (BHT) at a level of 2.27 mmol% in the diet for 1 week [4].
• In order to determine the susceptibility of newborn rats to 2-tert-butylphenol (2TBP) and 2,4-di-tert-butylphenol (DTBP) toxicity, studies were conducted with oral administration from postnatal days (PND) 4 to 21 and the findings were compared with results for young rats exposed from 5 or 6 weeks of age for 28 days [1].
• TBP produced phenoxyl radicals at pH >or= 9.0 and 2,4-di-t-butylphenol (DBP) at pH 12.5, but 3,3',5,5'-tetra-t-butyl-1,1'-biphenyl-2,2'-diol (bisDBP) did not, using ESR spectroscopy [5].

Associations of Prodox 146 with other chemical compounds

• Antioxidant effects of quinoline alkaloids and 2,4-di-tert-butylphenol isolated from Scolopendra subspinipes [6].
• Although none of the additives specified in the rubber formulations was a phenolic or catecholic derivative, known to be potential causes of chemically induced vitiligo, gas chromatographic analysis identified a para-substituted phenol (2,4-di-tert-butylphenol, DTBP) in solid samples of the most frequently used rubber [7].

References