Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

ACMC-1C8M7 (4- nitrophenyl)carbamoylmethanoic acid

Synonyms: AG-D-15492, SureCN3189929, NSC-57783, KST-1A2755, AC1L1PBO, ...

Waters, P.J. et al., Oehler, C. et al.

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Disease relevance of Oxalyl-p-nitroaniline

The new influenza virus drug 4-guanidino-2-deoxy-2,3-dehydro-N-acetylneuraminic acid (Zanamivir) exhibited an IC50 value of about 7 x 10(-5) M that was in the range of the 'classical' sialidase inhibitor 2-deoxy-2,3-dehydro-N-acetylneuraminic acid; the bacterial sialidase inhibitor 4-nitrophenyloxamic acid, however, was ineffective [1].

High impact information on Oxalyl-p-nitroaniline

Studies on whole homogenates of MNLs demonstrated that the Triton-stimulated and cholate-stimulated activities showed similar acidic pH optima at < or = 3.9 and were both strongly inhibited by 2-deoxy-2,3-didehydro-N-acetylneuraminic acid and Cu2+, but not by free N-acetylneuraminic acid, N-(4-nitrophenyl)oxamic acid or heparan sulphate [2].

References

Substrate specificity and inhibitor studies of a membrane-bound ganglioside sialidase isolated from human brain tissue. Oehler, C., Kopitz, J., Cantz, M. Biol. Chem. (2002) [Pubmed]
Freeze-stable sialidase activity in human leucocytes: substrate specificity, inhibitor susceptibility, detergent requirements and subcellular localization. Waters, P.J., Corfield, A.P., Eisenthal, R., Pennock, C.A. Biochem. J. (1994) [Pubmed]

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