The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CTK8J5372     [5-(6-aminopurin-9-yl)-4- hydroxy-2...

Synonyms: AR-1H5729, AC1L1A88, AC1Q68Z4
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of methacrylyl-coenzyme A


High impact information on methacrylyl-coenzyme A

  • These data support the hypothesis that CHY1 plays a key role in peroxisomal valine catabolism and that disruption of this enzyme results in accumulation of a toxic intermediate, methacrylyl-CoA, that inhibits 3-ketoacyl-CoA thiolase activity and thus blocks peroxisomal beta-oxidation [2].
  • Both enterocytes and colonocytes express high levels of 3-hydroxyisobutyryl-CoA hydrolase, an enzyme activity important in maintaining low intracellular concentrations of methacrylyl-CoA, a common, potentially toxic intermediate in the catabolic pathways of these compounds [3].
  • Specific assay of methacrylyl-CoA hydratase is needed for final proof that this is a new inborn error of that enzyme, but these findings and parental consanguinity make this very likely [4].


  1. Effects of liver failure on the enzymes in the branched-chain amino acid catabolic pathway. Shimomura, Y., Honda, T., Goto, H., Nonami, T., Kurokawa, T., Nagasaki, M., Murakami, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. An Arabidopsis mutant disrupted in valine catabolism is also compromised in peroxisomal fatty acid beta-oxidation. Lange, P.R., Eastmond, P.J., Madagan, K., Graham, I.A. FEBS Lett. (2004) [Pubmed]
  3. Catabolism of isobutyrate by colonocytes. Jaskiewicz, J., Zhao, Y., Hawes, J.W., Shimomura, Y., Crabb, D.W., Harris, R.A. Arch. Biochem. Biophys. (1996) [Pubmed]
  4. Two new sulphur-containing amino acids in man. Truscott, R.J., Malegan, D., McCairns, E., Halpern, B., Hammond, J., Cotton, R.G., Mercer, J.F., Hunt, S., Rogers, J.G., Danks, D.M. Biomed. Mass Spectrom. (1981) [Pubmed]
WikiGenes - Universities