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Chemical Compound Review:

HMDB06807 [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-4...

Synonyms: AC1L99WA, 3-Hydroxypropanoyl-Coenzyme A

Jaskiewicz, J. et al., Ooiwa, T. et al., Loupatty, F.J. et al., Fitzsimmons, M.E. et al., Sleeman, M.C. et al., et al.

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Disease relevance of C05668

In vitro polymerization and copolymerization of 3-hydroxypropionyl-CoA with the PHB synthase from Ralstonia eutropha [1].

High impact information on C05668

In cultured skin fibroblasts from both patients, the 3-hydroxyisobutyryl-CoA hydrolase activity was deficient, and virtually no 3-hydroxyisobutyryl-CoA hydrolase protein could be detected by western blotting [2].
Labeling experiments ruled out the possibility that hydrolysis proceeds via an anhydride in which water attacks a carbonyl derived from Glu(131), as proposed for 3-hydroxyisobutyryl-CoA hydrolase [3].
Incubation of DCTH-CoA with the medium-chain acyl-CoA dehydrogenase in the absence of FcPF6 gave 3-hydroxypropionyl-CoA as the major product and resulted in the irreversible inactivation of the enzyme [4].
In spite of comparable 3-hydroxyisobutyryl-CoA hydrolase activities in both cell types, and much greater amounts of 3-hydroxyisobutyrate dehydrogenase in colonocytes than in enterocytes, only the colonocytes produced 3-hydroxyisobutyrate as an endproduct of alpha-ketoisovalerate and isobutyrate catabolism [5].
Regulation of valine catabolism in canine tissues: tissue distributions of branched-chain aminotransferase and 2-oxo acid dehydrogenase complex, methacrylyl-CoA hydratase and 3-hydroxyisobutyryl-CoA hydrolase [6].

References

In vitro polymerization and copolymerization of 3-hydroxypropionyl-CoA with the PHB synthase from Ralstonia eutropha. Song, J.J., Zhang, S., Lenz, R.W., Goodwin, S. Biomacromolecules (2000) [Pubmed]
Mutations in the Gene Encoding 3-Hydroxyisobutyryl-CoA Hydrolase Results in Progressive Infantile Neurodegeneration. Loupatty, F.J., Clayton, P.T., Ruiter, J.P., Ofman, R., Ijlst, L., Brown, G.K., Thorburn, D.R., Harris, R.A., Duran, M., Desousa, C., Krywawych, S., Heales, S.J., Wanders, R.J. Am. J. Hum. Genet. (2007) [Pubmed]
Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis. Sleeman, M.C., Sorensen, J.L., Batchelar, E.T., McDonough, M.A., Schofield, C.J. J. Biol. Chem. (2005) [Pubmed]
Medium-chain acyl-CoA dehydrogenase- and enoyl-CoA hydratase-dependent bioactivation of 5,6-dichloro-4-thia-5-hexenoyl-CoA. Fitzsimmons, M.E., Thorpe, C., Anders, M.W. Biochemistry (1995) [Pubmed]
Catabolism of isobutyrate by colonocytes. Jaskiewicz, J., Zhao, Y., Hawes, J.W., Shimomura, Y., Crabb, D.W., Harris, R.A. Arch. Biochem. Biophys. (1996) [Pubmed]
Regulation of valine catabolism in canine tissues: tissue distributions of branched-chain aminotransferase and 2-oxo acid dehydrogenase complex, methacrylyl-CoA hydratase and 3-hydroxyisobutyryl-CoA hydrolase. Ooiwa, T., Goto, H., Tsukamoto, Y., Hayakawa, T., Sugiyama, S., Fujitsuka, N., Shimomura, Y. Biochim. Biophys. Acta (1995) [Pubmed]

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