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Chemical Compound Review

AG-E-36837     1-(butoxy-(2,2- dichloroethenoxy)phosphoryl...

Synonyms: CTK4D9668, LS-107617, BRN 1712889, AC1L3EF0, AI3-20756, ...
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Disease relevance of AI3-20756


High impact information on AI3-20756

  • The induction of central-peripheral distal axonopathy in hens singly dosed with some organophosphorus (OP) compounds, such as di-n-butyl-2,2-dichlorovinyl phosphate (DBDCVP), requires greater than 80% organophosphorylation and subsequent intramolecular rearrangement ("aging") of a protein [neuropathy target esterase (NTE)] in the axon [3].
  • Suprathreshold biochemical reaction, 24 h after dosing with DBDCVP (0.75-1.00 mg/kg s.c.), is shown to be associated with progressive decrement of retrograde axonal transport in sensory and motor fibers [3].

Anatomical context of AI3-20756


  1. Clinical expression of organophosphate-induced delayed polyneuropathy in rats. Moretto, A., Capodicasa, E., Lotti, M. Toxicol. Lett. (1992) [Pubmed]
  2. Time course of electrophysiologic effects induced by di-n-butyl-2,2-dichlorovinyl phosphate (DBCV) in the adult hen. Robertson, D.G., Mattson, A.M., Bestervelt, L.L., Richardson, R.J., Anderson, R.J. Journal of toxicology and environmental health. (1988) [Pubmed]
  3. Progressive deficit of retrograde axonal transport is associated with the pathogenesis of di-n-butyl dichlorvos axonopathy. Moretto, A., Lotti, M., Sabri, M.I., Spencer, P.S. J. Neurochem. (1987) [Pubmed]
  4. In vivo and in vitro regional differential sensitivity of neuropathy target esterase to di-n-butyl-2,2-dichlorovinyl phosphate. Moretto, A., Lotti, M., Spencer, P.S. Arch. Toxicol. (1989) [Pubmed]
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